An update on the treatment of patients with mCRPC with RA-223 plus AAP

Dr Tia Higano provides her perspective on ERA 223: A phase 3 trial of Ra-223 in combination with AAP in the treatment of asymptomatic or mildly symptomatic chemotherapy-naïve patients with bone-predominant mCRPC

An update on the treatment of patients with mCRPC with RA-223 plus AAP

Dr Tia Higano comments on the results of ERA223, a phase 3 trial that evaluated concurrent treatment of radium-223 (Ra-223) and abiraterone acetate and prednisone/prednisolone (AAP). Ra-223 and AAP are tested in the treatment of asymptomatic or mildly symptomatic chemotherapy naïve patients with bone predominant metastatic castration-resistant prostate cancer (mCRPC).

Dr Higano highlights important findings that influence clinical practice. In the accompanying slide set Dr Higano presents ERA223 trial results on the primary endpoint of symptomatic skeletal event-free survival, and the secondary endpoint of overall survival. Data on frequency of fractures is examined and the effect of bone health agents. Dr Higano concludes with advice on the use of radium and bone health agents in mCRPC. The video and accompanying slides provide medical education for medical oncologists, and we hope you find it of use for your own clinical practice.