Oncology  Video

Understand the MoA of PARP inhibitors and targeting DNA Damage Response (DDR)

Dr Robert L. Coleman

Dr Robert L. Coleman
Prof. Simon Boulton

Prof. Simon Boulton

Publication Date

Sep 2021

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A short video explaining the concept of DDR, the role of Homologous Recombination Repair (HRR) in DNA repair and the impact of BRCA1 and BRCA2 mutations. It explores PARP inhibitors as the proof of concept for targeting DDR, demonstrating how they work and their clinical benefit.

 

 

 

Dr Robert L. Coleman has received financial support/sponsorship for research support, consultation, or speaker fees from the following companies:

Amgen, Aravive, ArQuel, Cell Medica, Clovis, Geistlich Pharma, Genetech, GenMab, ImmunoGen, Janssen, Medscape, Merck, Mersana, MoreHealth, OncLive, OncoMed, Physicians Educational Resource, Takeda, Tesaro, TRM Oncology and United Therapeutics. 

Prof. Simon Boulton has received financial support/sponsorship for research support, consultation, or speaker fees from the following companies:

Artios Pharma Ltd.
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This educational programme is supported by an Independent Educational Grant from AstraZeneca
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