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In this interactive patient case video, Dr Escuriola will guide you through the case of a young man with severe haemophilia A who appears clinically stable, reporting no recent bleeds or joint problems. 

 

As you progress through the case, you will make key clinical decisions on joint assessment, imaging, and management strategies to determine whether subclinical joint disease may be present despite the absence of symptoms. 

 

This video is interactive. 

 

Click on the screen to: 

  • Respond to clinical questions 
  • Open folders in the video to access supplementary information

 

 

Clinical takeaways

  • Synovitis represents a critical window of opportunity before progressive joint damage becomes irreversible  
  • Absence of symptoms does not exclude active joint disease; subclinical bleeding and synovitis can occur despite prophylaxis  
  • Imaging, particularly point-of-care ultrasound, allows for early identification of early joint deterioration
  • Early identification of synovitis should prompt clinical reassessment and appropriate intervention to treat synovitis and help preserve long-term joint health and quality of life
  • Understand the pathophysiology of synovitis in haemophilia; how recurrent joint bleeds lead to synovial inflammation and progressive joint damage 
  • Recognise synovitis as an early and partially reversible stage of haemophilic arthropathy and understand clinical relevance for long-term preservation and pain outcomes 
  • Identify clinical signs, image findings, and symptoms associated with synovitis, and consider how they inform treatment optimisation
  • Apply strategies to manage synovitis with the aim of reducing joint inflammation, preventing progression to irreversible arthropathy, and improving quality of life 

Dr Carmen Escuriola Ettingshausen is the Director of the Haemophilia Centre Rhein Main - HZRM, Frankfurt, Germany. She graduated in medicine at the Johann Wolfgang Goethe-University in Frankfurt from 1985 to 1992. After that, she became resident at the comprehensive care centre for Thrombosis and Haemostasis of the Children´s Hospital at University Hospital of Frankfurt in the department of Paediatrics until 1996, and obtained the Doctor title in 1995. She performed specialist´s training in Paediatrics at the University Hospital of Frankfurt from 1996 until 2000, and since then she was a staff member at the comprehensive care centre for Thrombosis and Haemostasis of the University Hospital of Frankfurt, department of Paediatrics until 2012. In 2012 she founded the Haemophilia Centre Rhein-Main. Dr Escuriola-Ettingshausen’s clinical interests include haemorrhagic disorders with a focus on haemophilia, thrombosis, congenital immunodeficiencies, and hereditary angioedema in both paediatric and adult patients. Her research interests are haemorrhagic disorders, particularly in treatment of people with haemophilia and those in treatment with inhibitors. Moreover, she is member of the German, Swiss and Austrian Society for Thrombosis and Haemostasis Research (GTH), International Society for Thrombosis and Haemostasis (ISTH) and the International Prophylaxis Study Group (IPSG).

Dr Carmen Escuriola Ettingshausen has received financial support/sponsorship for research support, consultation, or speaker fees from the following companies:

Bayer Healthcare, Biomarin, Biotest, CSL Behring, Grifols, Kedrion, LFB, NovoNordisk, Octapharma, Pfizer, Roche/Chugai, Sanofi, Sobi, Takeda.​

Programme summary
  • clock Duration 10 MIN
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Other episodes of this series
Early diagnosis and management of synovitis in haemophilia

Early diagnosis and management of synovitis in haemophilia

How to detect early changes to prevent irreversible joint damage in people with haemophilia A

Detecting early joint disease in haemophilia A

Detecting early joint disease in haemophilia A

Explore early joint disease, subclinical bleeding, and strategies to prevent irreversible arthropathy

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Brought to you by COR2ED Medical Affairs. Initiated and funded by SobiTM.  For healthcare professionals only. NP-54318 September 2026
Supporter Acknowledgement
Brought to you by COR2ED Medical Affairs. Initiated and funded by SobiTM.  For healthcare professionals only. NP-54318 September 2026
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