Early diagnosis and management of synovitis in haemophilia

Synovitis represents a critical turning point in haemophilia care, often developing silently, even in patients receiving prophylaxis. Without early identification and appropriate management, persistent synovial inflammation can lead to progressive joint damage, reduced mobility, and a long-term impact on quality of life. 

In this medical educational programme, you'll explore the importance of early diagnosis and proactive management of synovitis in people with haemophilia A. Watch the video and view the accompanying slides to gain expert insights and practical guidance, highlighting how advances in treatment and monitoring can support improved long-term outcomes. 

This programme will help you: 

• Recognise the clinical significance of subclinical bleeding and its role in synovitis development 
• Understand why synovitis represents the last reversible stage before irreversible arthropathy 
• Explore the role of routine joint assessment, including imaging modalities such as ultrasound 
• Learn how to optimise and individualise prophylaxis, alongside multidisciplinary interventions, to support joint health 

Clinical takeaways

• Bleeding, including subclinical bleeding, can occur despite patients receiving prophylaxis  
• Synovitis is the last reversible step prior to further deterioration leading to arthropathy 
• Routine assessment of joint health status is therefore essential and should include imaging, such as ultrasound, to facilitate the detection of early abnormalities
• In people with haemophilia A and synovitis, prophylaxis should be intensified to resolve and/or reduce the synovial hypertrophy, alongside other measures (anti-inflammatory drugs, physiotherapy, etc.) to promote long-term joint health