GU CONNECT has summarised the highlights from ASCO for you.
GU cancer update by Prof. Sandy Srinivas, Stanford University Medical Center, Palo Alto CA, USA.
GU CONNECT member and genitourinary oncology expert Prof. Sandy Srinivas gives us an insight into new data presented at this years ASCO 2020 virtual conference. In this video discussion with accompanying slides, Prof. Sandy Srinivas highlights drug trials of interest and gives her expert opinion on the latest results of these trials, focusing on practice changing data. The aim of these slides and video is to provide support for medical urologists and oncologists.
The HERO phase III trial and advanced prostate cancer
Focal trials include the pivotal HERO phase 3 trial which compares relugolix, an oral GnRH receptor antagonist, to leuprolide acetate, a GnRH receptor agonist, in treatment of advanced prostate cancer. Discussed is the ability of relugolix to suppress testosterone compared to leuprolide, and clinical considerations for patient suitability.
The TheraP phase II trial and metastatic prostate cancer
Prof. Srinivas then addresses the initial results from the TheraP trial, a randomised phase 2 trial comparing 177LU-PSMA-617 to intravenous cabazitaxel in metastatic castration resistant prostate cancer (mCRPC). The radiolabelled small molecule 177LU-PSMA-617 targets therapeutic β-radiation to PSMA-expressing tumours. Patient outcomes, safety, and prostate specific antigen (PSA) results from this trial are examined. From these data, in context of the phase 3 VISION trial, Prof. Srinivas comments on the potential for drug sequencing in patients with mCRPC.
The IMvigor010 phase III trial; a new concept in targeting urothelial carcinoma
Next, data is covered from the IMvigor010 phase 3 study of adjuvant atezolizumab versus observation in high-risk muscle-invasive urothelial carcinoma (MIUC). This study represents an important concept in the treatment of MIUC, for which cystectomy, with or without cisplatin-based neoadjuvant chemotherapy, is the current standard of care. This trial examines the immune checkpoint inhibitor atezolizumab as adjuvant immunotherapy following cystectomy.
The Javelin 100 trial and emerging treatments in urothelial carcinoma
Prof. Srinivas then focuses on the phase 3 Javelin 100 trial, in which the immune checkpoint inhibitor avelumab is compared to best standard of care in patients with locally advanced or metastatic urothelial carcinoma previously treated with first-line platinum chemotherapy. Underscored are results in overall survival and progression-free survival. Shortly after the ASCO 2020 conference the FDA approved avelumab as a first-line maintenance treatment for patients with locally advanced or metastatic urothelial carcinoma following the results from the Javelin 100 trial.
Updates in androgen deprivation therapy in non-metastatic CRPC
Lastly, Prof Srinivas discusses updates in androgen deprivation therapy (ADT) for the treatment of patients with non-metastatic CRPC. Highlighted are three trials of FDA approved drugs: apalutamide, darolutamide, and enzalutamide. Focus from new data is on improvements in overall survival and hazard ratios. We hope that you find our video overview and slides insightful.
Sandy Srinivas specializes in urologic oncology and takes care of patients with prostate, bladder, kidney, testes, penile and adrenal cancers. She has practised in this field now for more than 20 years. She is the clinical research group leader for Urologic Program at Stanford and is a principal investigator on numerous trials in urologic Oncology and is the medical director for the in-patient hematology Oncology unit.
She serves as the Vice-chair on the National Comprehensive Cancer Center (NCCN) panel for prostate cancer and has co-authored numerous publications and book chapters.
She has received numerous teaching awards and is a nationally recognized expert in the field of Urologic Oncology.
Episode
3
of
GU CONNECT Update from ASCO GU 2020
Episode 3: Kidney Cancer
Experts
Assoc. Prof. Martin Pichler-
Downloadable
Resouces -
5 MIN
-
Oct 2021 -
Episode
2
of
GU CONNECT Update from ASCO GU 2020
Episode 2: Urothelial Cancer
Experts
Assoc. Prof. Shilpa Gupta-
Downloadable
Resouces -
5 MIN
-
Oct 2021
-
Episode
1
of
GU CONNECT: Update from ASCO GU 2020
Episode 1: Prostate Cancer
Experts
Dr Neal D. Shore-
Downloadable
Resouces -
5 MIN
-
Oct 2021
-
Programme summary
Duration 5 MIN
Downloadable resources Yes-
DOWNLOAD SLIDES - PPTX
-
Language(s)
Share this programme
Brought to you by
GU CONNECT is an initiative of COR2ED, supported by Independent Educational Grants from AstraZeneca, Bayer and Eisai Europe Limited.
Meet the experts
Other programmes of interest
Video
Oncology
Recent advances in precision oncology and future implications
Two emerging and two established targets
Experts
Prof. David Hong-
Downloadable
Resources -
4 MIN
-
Dec 2024
Publication
Oncology
Survey on the evolving role of the oncology nurse in the USA
Announcing the publication of survey results
Experts
Nina Grenon, Natasha Pinheiro, Karen Waldrop, Brittni Prosdocimo-
Downloadable
Resources -
10 MIN
-
Dec 2024
Video
Oncology
Elacestrant in ER+/HER2- metastatic breast cancer
An expert overview of the EMERALD subgroup analysis
Experts
Dr Virginia Kaklamani-
Downloadable
Resources -
4 MIN
-
Dec 2024
Video
Oncology
Systemic treatment options for patients with non-clear cell renal cell carcinoma (nccRCC)
Managing patients with nccRCC: guidelines, recommendations, and best practice
Experts
Prof. Laurence AlbigesEndorsed by
-
Downloadable
Resources -
4 MIN
-
Dec 2024
Micro learning
Oncology
Metastatic pancreatic ductal adenocarcinoma (PDAC): from diagnosis to treatment
Risk factors, diagnostic tools and treatment options for different patient groups
Experts
Prof. Efrat Dotan, Prof. Shubham PantEndorsed by
-
Downloadable
Resources -
4 MIN
-
Dec 2024
Conference update
Oncology
Rezatapopt in TP53 Y220C mutated metastatic breast cancer: PYNNACLE phase 1/2 update
Exploring emerging treatment strategies presented at SABCS 2024
Experts
Prof. Frédérique Penault-Llorca, Dr Ecaterina E Dumbrava-
Downloadable
Resources -
5 MIN
-
Dec 2024
