Listen and follow our podcasts on:

This educational programme is supported by an Independent Educational Grant from Menarini Stemline Oncology

In this podcast series, Prof. Shaheenah Dawood and Assoc. Prof. Rena Callahan discuss oral SERDs for ER+/HER2- advanced or metastatic breast cancer.

 

Episode 1: Oral SERDs in ER+ breast cancer: efficacy, safety and treatment landscape

The experts explore the efficacy and safety profiles of oral SERDs and their place in the treatment landscape, and discuss how to optimise treatment selection and make appropriate sequencing decisions.

 

Episode 2: Oral SERDs in ER+ breast cancer: treatment selection and beyond

A deep-dive into two patient case studies of ER+/HER2- metastatic breast cancer, discussing the intricacies of treatment selection and sequencing to maximise outcomes, current data, and what to consider when adjusting dosage or switching treatments.

 

Episode 3: Oral SERDS in ER+ breast cancer: rare cases & treatment challenges

Prof. Dawood and Assoc. Prof. Callahan discuss the next two patient case studies of ER+/HER2- metastatic breast cancer, each presenting unique and rare situations that shed a light on the challenges confronting healthcare professionals and patients alike.

 

 

Clinical Takeaways

 

  • Elacestrant was the 1st oral SERD to be FDA approved (January 2023), with optimal efficacy and manageable safety for patients with ESR1 mutated ER+/HER2- advanced or metastatic breast cancer

  • Factors such as disease progression, tumour burden, treatment-related toxicities, patient preferences and quality of life should be considered when deciding whether to adjust current treatment dosage or switch therapies

  • Maximising endocrine therapy options is recommended with and without targeted therapy in ER+/HER2- advanced or metastatic breast cancer

  • ESR1 mutation testing should be done with a liquid biopsy platform at the time of progression on an aromatase inhibitor as well as after subsequent lines of progression

  • Oral SERDs are being studied as a monotherapy and in combination with targeted therapies (i.e. CDK4/6, PI3K and AKT inhibitors), offering promising prospects for their integration into clinical practice

  • Recognise the efficacy and safety profiles of SERDs for patients with advanced or metastatic BC, and understand their place in the treatment landscape for patients with BC
  • Implement optimization of treatment selection, and make the appropriate sequencing decisions
  • Be able to identify and manage adverse events

Shaheenah Dawood is a Consultant medical oncologist and professor in clinical oncology in the United Arab Emirates. She trained in medical oncology at McGill University Hospitals in Canada and subspecialized in breast cancer management at MD Anderson Cancer Center. During her training she was awarded multiple scholar in training awards and ASCO merit awards. She has served as an editorial fellow at the New England Journal of medicine and has an MPH from the Harvard School of Public Health. She has over 100 papers to her credit including 50 peer review original articles, 30 review articles and 12 book chapters. She serves as a reviewer for multiple journals. She currently leads the oncology clinical trials program at Mediclinic City Hospital Dubai. She also serves as president of the Excellence in oncology summit that is held annually in Dubai and is co president of the Asia pacific breast cancer summit (ABCS) and Asia pacific gastrointestinal cancer summit (APGCS). She has also recently launched the international BRCA forum and young womens forum.

Prof. Shaheenah Dawood has received financial support/sponsorship for research support, consultation, or speaker fees from the following companies:

MSD, Roche, BMS, New Bridge, Novartis, llilly , Pfizer, Caris, Merck, Jaansen, Ipsen,Astrazeneca, Zulleg Pharma

Rena D. Callahan, MD, is Associate Clinical Professor of Health Sciences in the Division of Hematology-Oncology in the Department of Medicine at the University of Los Angeles, California (UCLA) David Geffen School of Medicine. She received her undergraduate degree from Yale University, and her medical degree from the University of Pennsylvania in Philadelphia, before completing an internship and residency in Internal Medicine and a fellowship in Hematology-Oncology at UCLA. Dr Callahan is board-certified in Internal Medicine, Medical Oncology, and Hematology. Dr Callahan is a member of the American Society of Clinical Oncology, the American Society of Hematology, and the American College of Physicians. She has served as principal or sub-investigator for numerous clinical research trials exploring topics related to breast cancer. Dr Callahan is a frequent lecturer on a variety of breast cancer topics and is focused on providing patient centered clinical care in the context of a large clinical practice.

Assoc. Clinical Professor Rena Callahan has received financial support/sponsorship for research support, consultation, or speaker fees from the following companies:

Support provided as a speaker from: Gilead, Lilly, Stemline, Seagen

Listen and follow our podcasts on:

This educational programme is supported by an Independent Educational Grant from Menarini Stemline Oncology

In this podcast series, Prof. Shaheenah Dawood and Assoc. Prof. Rena Callahan discuss oral SERDs for ER+/HER2- advanced or metastatic breast cancer.

 

Episode 1: Oral SERDs in ER+ breast cancer: efficacy, safety and treatment landscape

The experts explore the efficacy and safety profiles of oral SERDs and their place in the treatment landscape, and discuss how to optimise treatment selection and make appropriate sequencing decisions.

 

Episode 2: Oral SERDs in ER+ breast cancer: treatment selection and beyond

A deep-dive into two patient case studies of ER+/HER2- metastatic breast cancer, discussing the intricacies of treatment selection and sequencing to maximise outcomes, current data, and what to consider when adjusting dosage or switching treatments.

 

Episode 3: Oral SERDS in ER+ breast cancer: rare cases & treatment challenges

Prof. Dawood and Assoc. Prof. Callahan discuss the next two patient case studies of ER+/HER2- metastatic breast cancer, each presenting unique and rare situations that shed a light on the challenges confronting healthcare professionals and patients alike.

 

 

Clinical Takeaways

 

  • Elacestrant was the 1st oral SERD to be FDA approved (January 2023), with optimal efficacy and manageable safety for patients with ESR1 mutated ER+/HER2- advanced or metastatic breast cancer

  • Factors such as disease progression, tumour burden, treatment-related toxicities, patient preferences and quality of life should be considered when deciding whether to adjust current treatment dosage or switch therapies

  • Maximising endocrine therapy options is recommended with and without targeted therapy in ER+/HER2- advanced or metastatic breast cancer

  • ESR1 mutation testing should be done with a liquid biopsy platform at the time of progression on an aromatase inhibitor as well as after subsequent lines of progression

  • Oral SERDs are being studied as a monotherapy and in combination with targeted therapies (i.e. CDK4/6, PI3K and AKT inhibitors), offering promising prospects for their integration into clinical practice

  • Recognise the efficacy and safety profiles of SERDs for patients with advanced or metastatic BC, and understand their place in the treatment landscape for patients with BC
  • Implement optimization of treatment selection, and make the appropriate sequencing decisions
  • Be able to identify and manage adverse events

Shaheenah Dawood is a Consultant medical oncologist and professor in clinical oncology in the United Arab Emirates. She trained in medical oncology at McGill University Hospitals in Canada and subspecialized in breast cancer management at MD Anderson Cancer Center. During her training she was awarded multiple scholar in training awards and ASCO merit awards. She has served as an editorial fellow at the New England Journal of medicine and has an MPH from the Harvard School of Public Health. She has over 100 papers to her credit including 50 peer review original articles, 30 review articles and 12 book chapters. She serves as a reviewer for multiple journals. She currently leads the oncology clinical trials program at Mediclinic City Hospital Dubai. She also serves as president of the Excellence in oncology summit that is held annually in Dubai and is co president of the Asia pacific breast cancer summit (ABCS) and Asia pacific gastrointestinal cancer summit (APGCS). She has also recently launched the international BRCA forum and young womens forum.

Prof. Shaheenah Dawood has received financial support/sponsorship for research support, consultation, or speaker fees from the following companies:

MSD, Roche, BMS, New Bridge, Novartis, llilly , Pfizer, Caris, Merck, Jaansen, Ipsen,Astrazeneca, Zulleg Pharma

Rena D. Callahan, MD, is Associate Clinical Professor of Health Sciences in the Division of Hematology-Oncology in the Department of Medicine at the University of Los Angeles, California (UCLA) David Geffen School of Medicine. She received her undergraduate degree from Yale University, and her medical degree from the University of Pennsylvania in Philadelphia, before completing an internship and residency in Internal Medicine and a fellowship in Hematology-Oncology at UCLA. Dr Callahan is board-certified in Internal Medicine, Medical Oncology, and Hematology. Dr Callahan is a member of the American Society of Clinical Oncology, the American Society of Hematology, and the American College of Physicians. She has served as principal or sub-investigator for numerous clinical research trials exploring topics related to breast cancer. Dr Callahan is a frequent lecturer on a variety of breast cancer topics and is focused on providing patient centered clinical care in the context of a large clinical practice.

Assoc. Clinical Professor Rena Callahan has received financial support/sponsorship for research support, consultation, or speaker fees from the following companies:

Support provided as a speaker from: Gilead, Lilly, Stemline, Seagen

Programme summary
Listen to the podcast now
Other episodes of this series
Oral SERDs in ER+ breast cancer

Oral SERDs in ER+ breast cancer

Episode 1: Efficacy, safety and treatment landscape

Oral SERDs in ER+ breast cancer

Oral SERDs in ER+ breast cancer

Episode 2: Treatment selection and beyond

Oral SERDS in ER+ breast cancer

Oral SERDS in ER+ breast cancer

Episode 3: Rare cases & treatment challenges

Current Episode
Share this programme
This educational programme is supported by an Independent Educational Grant from Menarini Stemline Oncology
Supporter Acknowledgement
This educational programme is supported by an Independent Educational Grant from Menarini Stemline Oncology
Endorsement
I agree that this educational programme:

Was valuable to me

1/4
Brought to you by
BREAST CANCER CONNECT

BREAST CANCER CONNECT is an initiative of COR2ED, supported by an Independent Educational Grant from Menarini Stemline Oncology, AstraZeneca and Thermo Fisher Scientific.

Meet the experts Independent IME approved
Programme summary
  • clock Duration MIN
  • clock Language(s) flag
Listen to the podcast now
Other episodes of this series
Oral SERDs in ER+ breast cancer

Oral SERDs in ER+ breast cancer

Episode 1: Efficacy, safety and treatment landscape

Oral SERDs in ER+ breast cancer

Oral SERDs in ER+ breast cancer

Episode 2: Treatment selection and beyond

Oral SERDS in ER+ breast cancer

Oral SERDS in ER+ breast cancer

Episode 3: Rare cases & treatment challenges

Current Episode
Share this programme
This educational programme is supported by an Independent Educational Grant from Menarini Stemline Oncology
Supporter Acknowledgement
This educational programme is supported by an Independent Educational Grant from Menarini Stemline Oncology
Endorsement
I agree that this educational programme:

Was valuable to me

1/4
Brought to you by
BREAST CANCER CONNECT

BREAST CANCER CONNECT is an initiative of COR2ED, supported by an Independent Educational Grant from Menarini Stemline Oncology, AstraZeneca and Thermo Fisher Scientific.

Meet the experts Independent IME approved

Other programmes of interest

conference-update Conference update
Oncology 
Coming soon! Highlights from ESMO 2025

Experts are joining us at ESMO 2025 to share their views on new data on GU, lung, breast, gynecological and upper GI cancers

Experts
Dr Herbert H. Loong, Prof. Viktor Grünwald, Prof. Thomas Powles, Dr Elisa Agostinetto, Prof. Nicoletta Colombo, Dr Elizabeth Smyth
Endorsed by
Exon20group Biomarker Collaborative ICAN international cancer advocacy network
Lung Cancer Europe
  • clock MIN
  • calendar Oct 2025
  • Non-accredited Independent Medical Education

NSCLC and RCC updates supported by Independent Education Grants from Bayer and Eisai Europe Ltd. respectively. All other updates supported by COR2ED.
podcast Video podcast
Oncology Endocrinology Rare diseases 
Exploring the role of targeted radiopharmaceutical treatment in NETs

PRRT and emerging strategies in neuroendocrine tumours

Experts
Prof. Ken Herrmann, Dr Heloisa Soares, Oncology Brothers (Moderators)
Endorsed by
NANETS
CommNETs Neuroendocrine Cancer UK
  • download Downloadable
    Resources
  • clock 21 MIN
  • calendar Oct 2025
  • Non-accredited Independent Medical Education

Educational programme supported by an Independent Educational Grant from ITM.
ipcv Interactive Patient Case Video (IPCV)
Oncology 
Shared decision-making for prostate cancer patients

Early treatment intensification with a PARPi plus ARPI combination

Experts
Prof. Gunhild von Amsberg
Endorsed by
ZERO Urobel VZW | ASBL
EAUN
  • clock 25 MIN
  • calendar Sep 2025
  • Non-accredited Independent Medical Education

Educational programme supported by an Independent Educational Grant from AstraZeneca 
conference-update Conference update
Oncology 
Oncogene-addicted NSCLC highlights from WCLC 2025

Expert insights on the latest data in oncogene-addicted non-small cell lung cancer 

Experts
Dr Devika Das
Endorsed by
Exon20group Biomarker Collaborative ICAN international cancer advocacy network
Lung Cancer Europe
Lung Cancer Research Foundation
  • download Downloadable
    Resources
  • clock 5 MIN
  • calendar Sep 2025
  • Non-accredited Independent Medical Education

Educational programme supported by an Independent Educational Grant from Bayer.
podcast Video podcast
Oncology 
Understanding the BRAFV600E testing and treatment landscapes in NSCLC

Two perspectives, one aim: A pathologist and a medical oncologist in discussion

Experts
Assoc. Prof. Umberto Malapelle, Prof. Nicolas Girard
Endorsed by
ISLB
  • download Downloadable
    Resources
  • clock 5 MIN
  • calendar Sep 2025
  • Non-accredited Independent Medical Education

This content is intended for HCPs outside the UK & ROI only. The medical experts in this podcast are expressing their own views and not those of COR2ED, Supporters or their institution. This programme is supported by an Independent Educational Grant from Pierre Fabre Laboratories.  The programme is, therefore, independent; the content is not influenced by Pierre Fabre Laboratories and is under the sole responsibility of the experts.