Professor of Medicine Evan Yu and Associate Professor Tanya Dorff provide their thoughts and views on combination, sequential and immuno-oncology therapies in mCRPC (Metastatic Castration-Resistant Prostate Cancer)


The background of combination immunotherapy

In this video and accompanying slides Prof. Evan Yu and Prof. Tanya Dorff address how to treat metastatic castration-resistant prostate cancer (mCRPC) using combination and sequential immuno-oncology therapies. Prof. Yu discusses immuno-oncology in prostate cancer and details the need for combination therapies. Explored are current prostate cancer immunotherapy treatments such as Sipuleucel-T, and other IO treatments approved in other cancers and being investigated in prostate cancer. These include PD1 antibodies and PD-L1 antibodies. Prof. Yu describes a study examining the effect of enzalutamide treatment on PD-L1/2 tumor staining, and how this may be relevant for treating subpopulations of patients. Presented are data using the PD1 binding antibody, pembrolizumab, to treat PD-L1 positive prostate cancer.

The influence of mutational profile on immunotherapy response

Further discussion focuses on the prediction of solid tumour responsiveness to immunotherapy based on the mutational profile. Examined are mismatch repair with microsatellite instability (MSI) and DNA repair gene alterations in prostate cancer as a consideration for immunotherapy treatment. Also covered are the KEYNOTE 365 clinical trial which examines pembrolizumab in combination therapies with a number of different therapies in mCRPC, and ongoing trials in immunotherapy with focus on combination therapies. The slide-set concludes with a look at immunotherapy for the non-inflamed phenotype and how that can be addressed with immune priming strategies. Watch the video and download the slides to benefit from this practical guidance for medical oncologists.

Evan Y. Yu, M.D., is a medical oncologist specializing in prostate, bladder, and testicular cancer treatment and research.  He graduated Alpha Omega Alpha from the University of Washington School of Medicine. He completed internal medicine residency at the Brigham and Women’s Hospital and oncology fellowship and post-doctoral training at the Dana-Farber Cancer Institute. He returned to Seattle at the end of 2004 to join the faculty at the University of Washington and Fred Hutchinson Cancer Research Center. Dr Yu is a Full Professor of Medicine and Oncology, the Clinical Research Director for GU malignancies, Core Director for the Pacific Northwest Prostate Cancer SPORE and co-PI of the DoD Prostate Cancer Clinical Trials Consortium for his institution. His research focuses on testing the next wave of novel molecular targeted therapies and immunotherapy techniques, with a complementary focus on imaging biomarkers. In addition to an active clinical and research practice, he also is the Medical Director for Clinical Research Services at the Fred Hutchinson Cancer Consortium. Previously, he served as a Hematology/Oncology Fellowship Program Director for a decade at the Fred Hutchinson Cancer Research Center. He has regularly been voted a “Top Doctor” by Castle Connolly, U.S. News and World Report, Seattle magazine, and Seattle Met magazine. He has served for many years on the National Cancer Institute Genitourinary Cancers Steering Committee and is the Co-Chair for the National Cancer Institute Prostate Cancer Task Force. Dr Yu remains active in SWOG, the Cancer Immunotherapy Trials Network and he also serves as a senior editor for Clinical Cancer Research and Uro-Today.

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