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VEGFR-TKIs alone or in combination with immune checkpoint inhibitors in clinical practice for the treatment of HCC

VEGFR-TKIs alone or in combination with immune checkpoint inhibitors in clinical practice for the treatment of HCC

Prof. Dr. Peter R. Galle, Dr. Amit Singal

In this HCC CONNECT podcast Prof. P. Galle and Prof. A. Singal discuss and debate different aspects for the use of VEGFR-TKIs alone or in combination with immune checkpoint inhibitors in clinical practice, Implementation of dosing-strategies and pre-habilitation of patients .
Portrait of Peter R. Galle
Prof. Dr. Peter R. Galle

Hepatologist

University of Mainz

Germany

Portrait of Amit Singal
Dr. Amit Singal

Gastroenterologist and Hepatologist

UT Southwestern Medical Center

United States (US)

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In this medical education podcast episode, Prof. Peter Galle and Prof. Amit Singal discuss the use of VEGFR-TKIs in the treatment of advanced or unresectable HCC and explain the immunomodulation rationale to combine it with immune checkpoint inhibitor. Combination approach has been validated recently with the atezolizumab+bevacizumab combination being the new standard of care in 1L setting for advanced HCC patients. In the context of advanced HCC, both experts share their view about the dosing approach with VEGFR-TKI and provide insight to handle the dosing when combining with immune checkpoint inhibitors. Both experts reiterate that biomarkers are urgently needed in HCC and summarize the current stratification of patients used to predict the response with VEGFR-TKI monotherapy or in immunotherapy combination. Finally, they emphasize that pre-habilitation of HCC patients is key to make the HCC patient fit for the best available treatment option.

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