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How Coagulation Cascade Deficiencies Lead to Bleeding Disorders

How Coagulation Cascade Deficiencies Lead to Bleeding Disorders

A short video from bleeding disorder experts

A short video from bleeding disorder experts

Dr Vickie McDonald, Prof. Ana Boban

Many HCPs come into contact with patients with bleeding disorders like von Willebrand disease (VWD) or haemophilia. In this short animated video, guided by haematologists Dr Vickie McDonald and Prof. Ana Boban, you'll learn about:

  • Differences between primary and secondary haemostasis

  • The importance of interpreting laboratory coagulation

  • Consequences of the deficiencies in the coagulation cascade for von Willebrand disease and haemophilia A

Dr Vickie McDonald


Royal London Hospital and Queen Mary University of London

United Kingdom (UK)

Prof. Ana Boban


University Hospital Centre Zagreb


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Coagulation Cascade

time Video | open 4 min | Jul 2023

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Clinical Takeaways

  • Inherent bleeding disorders may be difficult to recognize and diagnose; better understanding of the primary and secondary haemostasis can ensure proper diagnosis and optimized care of those affected

  • Clotting time tests are useful tools to recognize and diagnose people with a potential bleeding disorder; consult a haematologist when in doubt

  • Patients with VWD may have normal PT and aPTT values, where more severe VWD can result in a prolonged aPTT due to low factor VIII levels; patients with haemophilia A have a prolonged aPPT value due low activity of factor VIII

This educational programme is supported by an Independent Medical Education Grant from Takeda

HEMOSTASIS CONNECT is an initiative of COR2ED, supported by an Independent Educational Grant from Takeda and Viatris.

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