In these short videos, Dr María Victoria Mateos, Dr Karthik Ramasamy, and Dr Elena Zamagni share insights from the symposium at the EHA 2025 Congress on 'Innovating relapsed refractory multiple myeloma care: Unmet needs, therapy management, and real-world experience', sponsored by Menarini Stemline.
Download the accompanying slides for further insights.
Key topics include:
- Addressing unmet needs with a new mechanism of action: Role and place of XPO1 inhibition
- Streamlining therapy management: Practical strategies for enhanced treatment outcomes
- Bridging evidence and practice: Real-world insights and clinical case discussions
Clinical takeaways
- Despite many novel therapeutics in R/R MM, unmet needs continue to exist, and we need to understand optimal sequencing to improve patient outcomes
- Available options in anti-CD38- and lenalidomide-refractory patients are limited, and Kd and PVd have their own safety challenges
- Selinexor introduces a novel MoA; the BOSTON trial validates its combination with bortezomib (SVd), and has an effective utility with double antiemetic prophylaxis and dose modifications
- Selinexor is included in worldwide guidelines for the management of patients with myeloma after at least 1 prior line in this competitive landscape:
- SVd showed benefit in the lenalidomide-refractory population, including survival benefit
- SVd is a viable treatment option that allows for the preservation of BCMA-TT for later lines*
- SVd can also be used after BCMA-TT in early lines, without compromising and potentially having a positive effect on subsequent lines of T-cell redirecting therapies*