Clinical takeaways:
PRODIGE 23 trial
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Induction chemotherapy with mFOLFIRINOX prior to preoperative chemoradiotherapy significantly improved overall survival compared with standard of care in patients with locally advanced rectal cancer
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7-year data confirms the benefit of neoadjuvant therapy in these patients
PROSPECT trial
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After 5 years, neoadjuvant FOLFOX with selective use of 5-FU chemoradiotherapy (5-FU CRT) was non-inferior to 5-FU CRT for disease-free survival in participants with locally advanced rectal cancer
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Omitting radiation therapy can reduce short- and long-term side effects that impact QOL, while providing similar outcomes in disease-free survival and overall survival