Clinical takeaways:
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DUO-O trial: Immunotherapy demonstrates positive Phase 3 results in advanced ovarian cancer, particularly for HR-deficient patients with high unmet needs, supporting its inclusion in the treatment regimen
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SHAPE trial: Practice-changing data demonstrates that in early-stage, low-risk cervical cancer, simple hysterectomy is non-inferior to radical hysterectomy in terms of pelvic recurrence rate at 3 years, supporting its adoption as a preferred treatment option
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KEYNOTE-826 trial: Pembrolizumab combined with chemotherapy, with or without bevacizumab, shows significant overall survival (OS) and progression-free survival (PFS) benefits in persistent, recurrent, or metastatic cervical cancer, warranting its use as a new standard of care. No new safety concerns arise with long-term follow-up