You can now access the on-demand resources from a virtual Experts Knowledge Share on multiple myeloma, chaired by Prof. Karthik Ramasamy (UK), and co-chaired by Dr Joshua Richter (US), Dr Andrew Charlton (UK), and Dr Faisal Basheer (UK). 

 

Topics of conversation include:   

  • ​​​Myeloma, bench to bedside: considerations at each line of therapy  
  • Every move matters: rethinking sequencing strategies in modern myeloma  
  • Clinical studies to clinical reality: patient case studies discussion 

 

Watch the on-demand video from the meeting and download the accompanying slides.

 

Clinical takeaways

  • Multiple myeloma evolves as a multi-clonal disease leading to resistance and refractoriness to multiple agents over time, creating a persistent unmet clinical need 
  • Despite therapeutic advances, there is a need for new drugs with different modes of action, e.g. XPO1 inhibition 
  • Careful consideration is required in how to sequence novel emerging T-cell engaging therapies optimally with existing treatments to maximise long-term outcomes  
    • Pre-clinical data have shown that selinexor has the potential to promote T-cell fitness and reduce T-cell exhaustion 
  • In the real-world setting, selinexor can be effective and its toxicities manageable, even in poor-prognosis settings such as lenalidomide-refractory disease: 
    • Median PFS with SVd vs Vd in Len-refractory multiple myeloma patients was 10.2 months vs 7.1 months, respectively 
    • Median OS with SVd vs Vd in Len-refractory multiple myeloma patients was 26.7 months vs 18.6 months, respectively 
  • Establish the current challenges in treating multiple myeloma, and explain how these challenges are driven by the genetic heterogeneity of the disease 
  • Understand how the evolving treatment landscape limits available treatment options with proven efficacy in the relapsed/refractory setting, especially for lenalidomide-refractory patients 
  • Establish the need for therapies with novel mechanisms of action in relapsed refractory multiple myeloma 
  • Explore the evolution of the UK multiple myeloma pathway and how real-world clinical dilemmas shape decisions across lines of treatment 
  • Discuss the role of selinexor within multiple myeloma treatment landscape for multiple myeloma through interactive case studies 

Karthik Ramasamy is a Consultant Haematologist at Oxford University Hospitals NHS Trust and Associate Professor of Haematology, Radcliffe Department of Medicine, Oxford UK. Dr Ramasamy is the Director of the Oxford Myeloma Translational Research Centre, and a Lead Clinician for myeloma and other plasma cell dyscrasias at the Thames Valley Cancer Alliance Group. He is the Divisional Lead for Cancer research for National Institute for Health Research, Clinical Research Network Thames Valley and South Midlands, UK. He is an executive member of the UK Myeloma Forum and is an active member of UK Myeloma Research Alliance. Karthik serves on the Myeloma UK Board, a patient charity exclusively dealing with myeloma advocacy and research. Dr Ramasamy completed his haematology training in London. Following this, he completed three years as a clinical research fellow working on bone marrow microenvironment in myeloma at King’s College London. Dr Ramasamy is a Chief Investigator of myeloma studies and his translational research interests are early diagnosis of myeloma, myeloma renal, bone disease and myeloma drug resistance mechanisms. Karthik has published over 50 papers and authored textbooks/ chapters on myeloma

Prof. Karthik Ramasamy has received financial support/sponsorship for research support, consultation, or speaker fees from the following companies:

Amgen, Adaptive, BMS, Biotech, GSK, Janssen, Karyopharm, Oncopeptides, Pfizer and Takeda. 

Joshua Richter, M.D., is an Associate Professor in the Myeloma Division at the Tisch Cancer Institute at the Icahn School of Medicine at Mount Sinai and the Director of Myeloma at the Blavatnik Family Chelsea Medical Center at Mount Sinai.  He completed undergraduate work at Johns Hopkins University and subsequently went on to medical school at New York Medical College. He completed residency at St. Vincent’s Hospital – New York Medical College.  Dr Richter completed his hematology/oncology fellowship at the Yale Cancer Center.  After completing fellowship he worked in the myeloma division at the John Theurer Cancer Center at Hackensack University Medical.  In 2018 he joined the Myeloma Division at Mount Sinai Hospital.   Dr Richter has been published in numerous oncology journals including NEJM, Blood, and the Journal of Clinical Oncology.   He has an interest in immunotherapy, multi-functional antibodies and precision medicine.

Dr Joshua Richter has received financial support/sponsorship for research support, consultation, or speaker fees from the following companies:

Adaptive Biotechnologies, AstraZeneca, BMS, Celgene, Janssen, Karyopharm, Oncopeptides, Secura Bio, Sanofi and X4 Pharmaceuticals. 

Consultant Haematologist at Cambridge University Hospitals NHS Foundation Trust specialising in multiple myeloma, acute leukaemia and stem cell transplantation / cellular therapy

Dr Faisal Basheer has received financial support/sponsorship for research support, consultation, or speaker fees from the following companies:

Honoraria: J&J, Jazz Pharmaceuticals

Speaker fees: Sanofi, Pfizer, Menarini Stemline, Daiichi-Sankyo

Sponsorships: AbbVie, Pfizer; Advisory: BMS, J&J

Dr Andrew Charlton is a Consultant Haematologist at the Northern Centre for Cancer Care where he has a particular interest in myeloma treatment, apheresis medicine and transfusion, and NHS Blood and Transplant.

 

Dr Charlton trained in the Northern Deanery as a Registrar and then worked at the Northern Centre for Cancer Care as a Clinical Fellow in the Haemato-Oncology Clinical Trials Team.

 

He has a strong interest in developing the clinical trials portfolio at the Trust and was awarded NIHR ‘Greenshoots’ funding. He is Clinical Lead for Transfusion and part of the Sub-Regional Immunoglobulin Assessment Panel. He is an examiner for the FRCPath examination.

Dr Andrew Charlton has received financial support/sponsorship for research support, consultation, or speaker fees from the following companies:

Advisory Board: Sanofi, Takeda

Consultancy: Menarini Stemline, BMS

Speaker’s Fees: JNJ, Takeda, Sanofi, Menarini Stemline, Pfizer

Conference Support: JNJ, Takeda, Amgen, BMS, Menarini Stemline

You can now access the on-demand resources from a virtual Experts Knowledge Share on multiple myeloma, chaired by Prof. Karthik Ramasamy (UK), and co-chaired by Dr Joshua Richter (US), Dr Andrew Charlton (UK), and Dr Faisal Basheer (UK). 

 

Topics of conversation include:   

  • ​​​Myeloma, bench to bedside: considerations at each line of therapy  
  • Every move matters: rethinking sequencing strategies in modern myeloma  
  • Clinical studies to clinical reality: patient case studies discussion 

 

Watch the on-demand video from the meeting and download the accompanying slides.

 

Clinical takeaways

  • Multiple myeloma evolves as a multi-clonal disease leading to resistance and refractoriness to multiple agents over time, creating a persistent unmet clinical need 
  • Despite therapeutic advances, there is a need for new drugs with different modes of action, e.g. XPO1 inhibition 
  • Careful consideration is required in how to sequence novel emerging T-cell engaging therapies optimally with existing treatments to maximise long-term outcomes  
    • Pre-clinical data have shown that selinexor has the potential to promote T-cell fitness and reduce T-cell exhaustion 
  • In the real-world setting, selinexor can be effective and its toxicities manageable, even in poor-prognosis settings such as lenalidomide-refractory disease: 
    • Median PFS with SVd vs Vd in Len-refractory multiple myeloma patients was 10.2 months vs 7.1 months, respectively 
    • Median OS with SVd vs Vd in Len-refractory multiple myeloma patients was 26.7 months vs 18.6 months, respectively  
  • Establish the current challenges in treating multiple myeloma, and explain how these challenges are driven by the genetic heterogeneity of the disease 
  • Understand how the evolving treatment landscape limits available treatment options with proven efficacy in the relapsed/refractory setting, especially for lenalidomide-refractory patients 
  • Establish the need for therapies with novel mechanisms of action in relapsed refractory multiple myeloma 
  • Explore the evolution of the UK multiple myeloma pathway and how real-world clinical dilemmas shape decisions across lines of treatment 
  • Discuss the role of selinexor within multiple myeloma treatment landscape for multiple myeloma through interactive case studies 

Karthik Ramasamy is a Consultant Haematologist at Oxford University Hospitals NHS Trust and Associate Professor of Haematology, Radcliffe Department of Medicine, Oxford UK. Dr Ramasamy is the Director of the Oxford Myeloma Translational Research Centre, and a Lead Clinician for myeloma and other plasma cell dyscrasias at the Thames Valley Cancer Alliance Group. He is the Divisional Lead for Cancer research for National Institute for Health Research, Clinical Research Network Thames Valley and South Midlands, UK. He is an executive member of the UK Myeloma Forum and is an active member of UK Myeloma Research Alliance. Karthik serves on the Myeloma UK Board, a patient charity exclusively dealing with myeloma advocacy and research. Dr Ramasamy completed his haematology training in London. Following this, he completed three years as a clinical research fellow working on bone marrow microenvironment in myeloma at King’s College London. Dr Ramasamy is a Chief Investigator of myeloma studies and his translational research interests are early diagnosis of myeloma, myeloma renal, bone disease and myeloma drug resistance mechanisms. Karthik has published over 50 papers and authored textbooks/ chapters on myeloma

Prof. Karthik Ramasamy has received financial support/sponsorship for research support, consultation, or speaker fees from the following companies:

Amgen, Adaptive, BMS, Biotech, GSK, Janssen, Karyopharm, Oncopeptides, Pfizer and Takeda. 

Joshua Richter, M.D., is an Associate Professor in the Myeloma Division at the Tisch Cancer Institute at the Icahn School of Medicine at Mount Sinai and the Director of Myeloma at the Blavatnik Family Chelsea Medical Center at Mount Sinai.  He completed undergraduate work at Johns Hopkins University and subsequently went on to medical school at New York Medical College. He completed residency at St. Vincent’s Hospital – New York Medical College.  Dr Richter completed his hematology/oncology fellowship at the Yale Cancer Center.  After completing fellowship he worked in the myeloma division at the John Theurer Cancer Center at Hackensack University Medical.  In 2018 he joined the Myeloma Division at Mount Sinai Hospital.   Dr Richter has been published in numerous oncology journals including NEJM, Blood, and the Journal of Clinical Oncology.   He has an interest in immunotherapy, multi-functional antibodies and precision medicine.

Dr Joshua Richter has received financial support/sponsorship for research support, consultation, or speaker fees from the following companies:

Adaptive Biotechnologies, AstraZeneca, BMS, Celgene, Janssen, Karyopharm, Oncopeptides, Secura Bio, Sanofi and X4 Pharmaceuticals. 

Consultant Haematologist at Cambridge University Hospitals NHS Foundation Trust specialising in multiple myeloma, acute leukaemia and stem cell transplantation / cellular therapy

Dr Faisal Basheer has received financial support/sponsorship for research support, consultation, or speaker fees from the following companies:

Honoraria: J&J, Jazz Pharmaceuticals

Speaker fees: Sanofi, Pfizer, Menarini Stemline, Daiichi-Sankyo

Sponsorships: AbbVie, Pfizer; Advisory: BMS, J&J

Dr Andrew Charlton is a Consultant Haematologist at the Northern Centre for Cancer Care where he has a particular interest in myeloma treatment, apheresis medicine and transfusion, and NHS Blood and Transplant.

 

Dr Charlton trained in the Northern Deanery as a Registrar and then worked at the Northern Centre for Cancer Care as a Clinical Fellow in the Haemato-Oncology Clinical Trials Team.

 

He has a strong interest in developing the clinical trials portfolio at the Trust and was awarded NIHR ‘Greenshoots’ funding. He is Clinical Lead for Transfusion and part of the Sub-Regional Immunoglobulin Assessment Panel. He is an examiner for the FRCPath examination.

Dr Andrew Charlton has received financial support/sponsorship for research support, consultation, or speaker fees from the following companies:

Advisory Board: Sanofi, Takeda

Consultancy: Menarini Stemline, BMS

Speaker’s Fees: JNJ, Takeda, Sanofi, Menarini Stemline, Pfizer

Conference Support: JNJ, Takeda, Amgen, BMS, Menarini Stemline

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Share this programme
This programme has been sponsored by Menarini Stemline and is intended for HCPs in the UK only    MAT-GB-SEL-00774
Supporter Acknowledgement
This programme has been sponsored by Menarini Stemline and is intended for HCPs in the UK only    MAT-GB-SEL-00774
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Was valuable to me

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