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Current perspectives on TRK fusion-positive thyroid cancers

Current perspectives on TRK fusion-positive thyroid cancers

Clinical summary video and slides

Clinical summary video and slides

Prof. Ezra Cohen

In this 5-min video update, Prof. Ezra Cohen summarises current perspectives on the diagnosis and treatment of TRK fusion-positive cancers. He discusses US and European guidelines, two recent key publications and larotrectinib data presented at the American Thyroid Association annual meeting.

 

Clinical takeaways:

  • NTRK fusions are more common in paediatric compared to adult thyroid cancers, testing is warranted in both populations
  • NTRK2 fusions have not been seen in thyroid cancer, only NTRK1 and NTRK3 fusions
  • Larotrectinib and entrectinib are two approved TRK inhibitors showing durable responses with favourable safety profiles
  • There are differences in the prognosis of NTRK1 vs NTRK3 fusion-positive thyroid cancer and differentiated vs anaplastic thyroid cancers
Portrait of Ezra Cohen
Prof. Ezra Cohen

Medical Oncologist

Moores Cancer Center, San Diego

United States (US)

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This educational programme is supported by an Independent Medical Education Grant from Bayer

PRECISION ONCOLOGY CONNECT is an initiative of COR2ED, supported by an Independent Educational Grant from Bayer.

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