Conference Update: ASCO and WCGIC 2023

In this clinical update video, Prof. Andrea Sartore-Bianchi shares his perspective on key data from ASCO and the World Conference on Gastrointestinal Cancer (WCGIC), 2023.

He reviews data from:

• DESTINY-PanTumor02 trial in HER2-expressing solid tumours 
• KontRASt-01 trial in non-small cell lung cancer (NSCLC)
• ADVL 1823 trial in infantile fibrosarcoma
• A retrospective study on molecular profiling on advanced biliary tract cancers

Clinical Takeaways

• DESTINY-PanTumour02: Study shows T-DXd to be a potential new treatment option for patients with HER2-expressing solid tumours, with higher efficacy in IHC 3+ and efficacy also in anti-HER2 pre-treated patients

• KontRASt-01: JDQ443 exhibits potent antitumour activity in NSCLC with good disease control and partial responses, as well as a good tolerability profile

• ADVL1823: First data in first-line treatment with larotrectinib in the NTRK+ infantile fibrosarcoma population, with data suggesting that local control (surgery) remains important to achieve long-term results

• Molecular Profiling in Biliary Cancers (BTC): the study highlights the importance of conducting NGS upfront for BTC. Treatment with a matched targeted therapeutic provides benefit in terms of DCR, PFS and OS

Selected abstracts

ASCO 2023

Efficacy and safety of trastuzumab deruxtecan (T-DXd) in patients (pts) with HER2-expressing solid tumors: DESTINY-PanTumor02 (DP-02) interim results.

• Abstract: LBA3000
• Presenter: Funda Meric-Bernstam, MD

KontRASt-01 update: Safety and efficacy of JDQ443 in KRAS G12C-mutated solid tumors including non-small cell lung cancer (NSCLC).

• Abstract: 9007
• Presenter: Philippe Alexandre Cassier MD, PhD

Phase 2 study of larotrectinib in children with newly diagnosed infantile fibrosarcoma (IFS): Children’s Oncology Group (COG) ADVL1823 cohort A.

• Abstract: 10008
• Presenter: Theodore Willis Laetsch, MD

WCGIC 2023

SO-4 Impact of molecular profiling on survival in patients with advanced biliary tract cancers.

• Short Oral Presentation Clinical Biliary Tract Cancer, Biomarkers and Translational Research
• Presenter: Leony Anton