Drs Herbert Loong and Isabel Preeshagul joined us live from ASCO 2026 to share their thoughts on the latest data in HER2-mutant non-small cell lung cancer (NSCLC) presented at the meeting.
Watch the video to get their expert views and perspectives on the following abstracts:
- SOHO-01: Updated safety and efficacy of sevabertinib in patients with advanced HER2-mutant NSCLC. Loong H, et al. Abstract 8622, ASCO 2026
- PRO results from the Beamion LUNG-1 trial in treatment-naïve patients with HER2-mutant advanced NSCLC. Sabari J.K, et al. Abstract 8616, ASCO 2026
- Beamion LUNG-3: Zongertinib in resectable HER2-mutant NSCLC. Cummings A, et al. Abstract TPS8129, ASCO 2026
- Best practices in HER2 testing: Advancing HER2 testing and evidence-based treatment in NSCLC: A quality improvement initiative across academic and community settings. McKinnon K.E, et al. Abstract e23309, ASCO 2026
Clinical takeaways
- SOHO-01: Sevabertinib continues to show robust and durable antitumour activity with a manageable safety profile in HER2-mutant NSCLC, supporting its role as an effective targeted therapy in both first-line and previously treated settings
- PROs from Beamion Lung-1: first-line zongertinib is associated with early and durable improvements in symptoms and physical functioning, with minimal patient-reported treatment burden, reinforcing its favourable benefit–risk profile in HER2-mutant NSCLC
- Beamion Lung-3: this ongoing trial will determine whether adjuvant zongertinib can reduce recurrence risk and improve survival after surgery for stage II-IIIB HER2-mutant NSCLC, potentially establishing HER2-targeted therapy as a new standard in the adjuvant setting
- Advancing HER2 Testing: HER2 testing gaps in NSCLC are primarily institutional and operational, and closing them will be essential to ensuring patients are appropriately identified for biomarker-directed therapies
Want to know more about the data? View and download the accompanying slides on the 'Slides' tab for a deeper dive.







Downloadable
1 MIN
May 2026
