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This educational programme is supported by an Independent Educational Grant from Bayer

Listen to a deep-dive into optimising treatment sequencing for patients with metastatic colorectal cancer, 3rd line and beyond, from Dr Jenny Seligmann and Dr Shubham Pant.

In the podcast, the experts discuss what clinicians should consider when making treatment decisions. You'll learn about

  • the potential treatment options for patients with advanced mCRC
  • the latest available data
  • which patient considerations are important when making treatment decisions

 

Clinical Takeaways

  • Molecular profiling has an important role in determining treatment options and sequence

  • Physicians should consider patient characteristics, such as comorbidities, toxicities from prior treatments, and overall performance status

  • Treatment from earlier lines of therapy is critical to treatment decisions in the 3rdline and beyond

  • There are a lot of new developments in the third-line treatment space for mCRC patients

  • Patients should receive as many treatment options as possible, and this should be considered during sequencing decisions

Dr Jenny Seligmann gained her MBChB and BMedSci at the University of Aberdeen in 2005 then gained her PhD in 2015 from the University of Leeds on Biomarkers of Prognosis and Prediction of Response in Colorectal Cancer. She was appointed a Cancer Research UK Clinical Trials Fellow in 2015, then a University Academic Fellow and Consultant in Medical Oncology in Leeds in 2017. Her research interests are in clinical trials and biomarkers of prediction of response in colorectal cancer. She is involved in several ongoing clinical trials, including the FOCUS-4 trial and has an ongoing lab-based programme of research. She has been involved in several national and international committees, including the UK Colorectal Clinical Studies Group and is currently the EORTC GI Group Young Investigator. She has received several awards including an ASCO Merit Award in 2013.

Prof. Jenny Seligmann has received financial support/sponsorship for research support, consultation, or speaker fees from the following companies:

Merck Serono, Pierre Fabre and Roche Diagnostics. 

Dr. Shubham Pant is a Professor in the Department of Gastrointestinal (GI) Medical Oncology with a joint appointment in the Department of Investigational Cancer Therapeutics (Phase I Center) at The University of Texas MD Anderson Cancer Center. Dr. Pant is recognised as an international expert in GI cancers with an emphasis on pancreatic and biliary cancers and Phase 1 trials.

 

Dr. Pant's research focuses on novel immunotherapeutic approaches and targeted therapies in GI cancers, including devising novel ways to target the KRAS mutation. He has been the lead/co-lead of several global practice-changing studies, including 'Zanidatamab for HER2-amplified, unresectable, locally advanced or metastatic biliary tract cancer (HERIZON-BTC-01): a multicenter, single-arm, phase 2b study'; 'Adagrasib in advanced solid tumors harboring a KRASG12C mutation' and 'Erdafitinib in patients with advanced solid tumors with FGFR alterations (RAGNAR): an international, single-arm, phase 2 study'; amongst others. He has over 100 peer-reviewed publications and has published in high-impact journals, including The Lancet, Lancet Oncology, and Journal of Clinical Oncology. He is frequently invited to present his research at national and international meetings. He collaborates on numerous grants, including R01 and SPORE grants funded by the National Institute of Health. Dr. Pant serves on the National Cancer Institute (NCI) Pancreas Task Force and the Pancreatic Cancer Action Network's (PanCan) Scientific and Medical Advisory Board. He also helped draft the American Society of Clinical Oncology (ASCO) Metastatic Pancreatic Cancer Guidelines, which provide evidence-based recommendations for physicians. He is also the editor of the book Pancreatic Cancer: Current Therapeutics and Future Directions (Publisher: Springer).

Prof. Shubham Pant has received financial support/sponsorship for research support, consultation, or speaker fees from the following companies:

Alligator Bioscience, Amal Therapeutics, Arcus, AskGene Pharma, Astellas, AstraZeneca, BioNTech, Boehringer Ingelheim, BPGBio, Bristol-Myers Squibb, Elicio, Framewave, Immuneering, ImmunoMET, Ipsen, Janssen, Jazz, Lilly, Mirati Therapeutics, NGM Pharmaceuticals, Nihon Medi-Physics Co, Ltd, Novartis, Pfizer, Revolution Medicine, Theriva Biosciences, USWorldmeds, Zymeworks

Experts
Prof. Sebastian Stintzing, Dr Juan Manuel O'Connor
  • download Downloadable
    Resouces
  • clock 9 MIN
  • calendar Jan 2023
  • Non-accredited Independent Medical Education
This educational programme is supported by an Independent Educational Grant from Bayer
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GI CONNECT is an initiative of COR2ED, supported by Independent Educational Grants from Bayer, Ipsen, BeiGene Europe and Pierre Fabre.  

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