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In this HCC CONNECT podcast Prof. Matthias Pinter discusses the key topics and abstracts as well as clinical implications in hepatocellular carcinoma presented at the recent 2021 ILCA ands ESMO congresses.

 

Professor Matthias Pinter, medical hepatologist from the medical University of Vienna in Austria shares some insights from key abstracts and topics discussed at ILCA 2021 and ESMO 2021 in hepatocellular carcinoma.

One main topic included discussions about treatment options in first-line systemic therapy and managing patients who still may need to receive a TKI in first-line instead. Another topic covered is how to proceed with immunotherapy in HCC, in particular the rationale for triplet immunotherapy combination.

There were two studies data presented on atezolizumab plus bevacizumab, the new reference standard of care in systemic front-line HCC treatment.

Another interesting topic was the combination of TACE with immune checkpoint blockade in intermediate stage HCC.

Regarding monotherapy TKI in first-line setting, Prof Pinter points out that around 15 to 20% of HCC patients are not ideal candidates for atezolizumab plus bevacizumab, and these are mainly patients with HCC recurrence of the liver transplantations, patients with severe autoimmune disease, or those with a high bleeding risk.

He discusses several real-world evidence studies including lenvatinib, sorafenib and regorafenib in special populations that are usually excluded from clinical trials.

Prof Pinter also discusses data presented covering predictive and prognostic biomarkers such as cachexia, the growing role of AI, multibipolar radiofrequency ablation and the potential role of underlying etiology as a predictor of the efficacy of immunotherapy.

Mahir Karababa (Moderator, Scientific Lead at COR2ED)

In this episode Professor Pinter will share some insights from key abstracts and topics discussed at ILCA 2021 and ESMO 2021 in hepatocellular carcinoma. Professor Pinter, first of all, from your point of view, what were the key topics covered during these two virtual congresses this year on HCC?

Matthias Pinter

Well at ILCA, the main topics included discussions about treatment options in first-line systemic therapy since we have a new…

Dr Matthias Pinter works at the Medical University of Vienna in Austria where he also received both his MD and PhD. He is board-certified for Internal Medicine and Gastroenterology and Hepatology. Since 2017, he has led the hepatocellular carcinoma programme and research group at the Division of Gastroenterology and Hepatology at the Medical University of Vienna. His main research interests include the systemic treatment of liver cancer, particularly the identification of prognostic markers and scores that may help to identify patients most likely to benefit from specific therapies. To broaden his knowledge and expertise in basic research and experimental oncology, he worked as a research fellow and postdoc at renowned institutions, including the University of Bern in Switzerland and the Massachusetts General Hospital/Harvard Medical School in the United States. He has published numerous original papers and review articles on liver cancer in prestigious peer-reviewed journals covering the categories oncology, gastroenterology and hepatology, and radiology.

Assoc. Prof. Matthias Pinter has received financial support/sponsorship for research support, consultation, or speaker fees from the following companies:

Bayer, BMS, Ipsen, Eisai, Lilly, MSD and Roche.

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  • calendar Sep 2022
HCC CONNECT Update from ESMO 2019

HCC CONNECT has summarised highlights of the recent ESMO 2019 meeting for you

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  • calendar Sep 2021
This educational programme is supported by an Independent Medical Education Grant from Bayer
HCC CONNECT Update from ILCA and ESMO 2020

HCC CONNECT has summarised the highlights from ILCA and ESMO 2020 for you.Liver Cancer update by Dr. Su Pin Choo, Curie Oncology and National Cancer Centre, Singapore

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Dr Su Pin Choo
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  • calendar Sep 2021
This educational programme is supported by an Independent Medical Education Grant from Bayer
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HCC CONNECT is an initiative of COR2ED, supported by Independent Medical Educational Grants from AstraZeneca, Bayer and Eisai Europe Limited.

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