Dr Walid Ayoub discusses recent data on surveillance and novel risk factors for hepatocellular carcinoma (HCC).

Dr Walid Ayoub has been engaged in the field of hepatology for the last 15 years. For the last two decades, he has treated patients with various forms of liver disease, including patients with liver cirrhosis and liver cancer. Dr Ayoub has served as the interim Medical Director for Liver Transplantation at Cedars Sinai Medical Center. He has been a regular speaker at regional and national liver meetings in the USA educating current and future gastroenterologists and hepatologists about liver diseases and liver cancer. He is an active member of the American Association for the Study of Liver Diseases (AASLD) and the American Society of Transplantation (AST). He also serves on the Medial Education Committee for the American Liver Foundation. He has participated in multiple pharma sponsored clinical trials on the use of direct acting antiviral therapy in patients with hepatitis C, cholestatic liver disease, hepatitis B and liver cancer. He is currently co-principal investigator on two National Institute of Health sponsored trials on the use of statins as chemoprevention for the development of liver cancer. Relevant publications Ayoub W, Geller SA, Tran T, Martin P, Vierling JM, Poordad F. Imatinib (Gleevec) Hepatotoxicity: a Case Report. J Clin Gastroenterol 2005; 39, 1:75-77. Ayoub WS, Keeffe EB. Management of Hepatitis B in Patients with HBe-Ag Negative Disease. Current Hepatitis Reports 2007;6,3: 91-95. Ayoub WS, Keeffe EB. Current Management of Chronic Hepatitis B. US Gastroenterology and Hepatology Review 2008;4,2:28-31. Ayoub, WS. Tenofovir - A New Option for the Treatment of Chronic Hepatitis B. Virus Adaptation and Treatment 2009;1:5-10. De Luna W, Sze DY, Ahmed A, Ha BY, Ayoub W, Keeffe EB, Cooper A, Esquivel C, Nguyen MH. Transarterial chemoinfusion for hepatocellular carcinoma as down staging therapy and a bridge toward liver transplantation. Am J Transplant 2009;9,5:1158-68. Ayoub WS, Esquivel CO, Martin P. Biliary complications following liver transplantation. Dig Dis Sci 2010; 55 ( 60): 1540-46. Ayoub WS, Keeffe EB. Current Antiviral Therapy of Chronic HBV infection. Aliment Pharmacol Ther 2011;34,10: 1145-58. Ho EY, Ha NB, Ahmed A, Ayoub W, Daugherty T, Garcia G, Cooper A, Keeffe EB, Nguyen MH. Prospective study of risk factors for hepatitis C virus acquisition by Caucasian, Hispanic, and Asian American patients. J Viral Hepat 2012; 19: 2: e105-11. Ha NB, Ha NB, Ahmed A, Ayoub W, Daugherty TJ, Chang ET, Lutchman GA, Garcia G, Cooper AD, Keeffe EB, Nguyen MH. Risk factors for hepatocellular carcinoma in patients with chronic liver disease: a case-control study. Cancer Causes Control 2012;23(3):455-62. Mair RD, Valenzuela A, Ha NB, Ayoub WS, Daugherty T, Lutchman GA, Garcia G, Ahmed A, Nguyen MH. Incidence of Hepatocellular Carcinoma Among US Patients With Cirrhosis of Viral or Nonviral Etiologies. Clin Gastroenterol Hepatol 2012;10,12:1412-17. Wong RJ, Ayoub WS. Current Treatment Strategies for the Management of Chronic Hepatitis B. JCOM 2012;20,1:36-47. Lin H, Ha NB, Ahmed A, Ayoub W, Daugherty TJ, Lutchman GA, Garcia G, Nguyen MH. Both HCV and HBV are Major Causes of Liver Cancer in Southeast Asians. J Immigr Minor Health 2013;15,6:1023-29. Nguyen, LH, Chao D, Lim JK, Ayoub W, Nguyen MH. Histologic Changes in Liver Tissue From Patients With Chronic Hepatitis B and Minimal Increases in Levels of Alanine Aminotransferase: A Meta-analysis and Systematic Review. Incidence of Hepatocellular Carcinoma Among US Patients With Cirrhosis of Viral or Nonviral Etiologies. Clin Gastroenterol Hepatol 2014:12,8:1262-6. Chao DT, Lim JK, Ayoub WS, Nguyen LH, Nguyen MH. Systematic review with meta-analysis: The proportion of Chronic Hepatitis B Patients with Normal ALT ≤ 40 IU/L and Significant Hepatic Fibrosis. Aliment Pharmacol Ther 2014:39,3:349-58. Nguyen KD, Sundaram V, Ayoub WS. Atypical causes of cholestasis. World J Gastroenterol 2014 Jul 28;20(28):9418-26 Valenzuela A, Ha NB, Gallo A, Bonham C, Ahmed A, Melcher M, Kim LH, Esquivel C, Concepcion W, Ayoub WS, Lutchman GA, Daugherty T, Nguyen MN. Recurrent Hepatocellular Carcinoma and Poorer Overall Survival in Patients Undergoing Left-sided Compared With Right-sided Partial Hepatectomy. J Clin Gastroenterol 2015; 49(2):158-64. Sundaram V, Choi G, Jeon C, Ayoub WS, Nissen NN, Klein AS, Tran T. Donation after cardiac death Liver transplantation in primary sclerosing cholangitis: Proceed with caution. Transplantation 2015:99,5:973-78. Zhang B, Nguyen NH, Yee BE, Yip B, Ayoub WS, Lutchman GA, Nguyen MH. Treatment of Acute Hepatitis C Infection with Pegylated Interferon and Ribavirin in Patients Coinfected with Human Immunodeficiency Virus: A Systematic Review and Meta-Analysis. Intervirology 2015;58(4):242-9. Annamalai A, Ayoub W, Sundaram V, Bresee B, Klein A. A first look: One year since inception of Regional Share 35 Policy. Transplant Proceedings 2015; 47(6):1585-90. Ayoub WS, Cohen E. Hepatitis B Management in the Pregnant Patient: An Update. J Clin Transl Hepatol 2016;4(3):241-247. Annamali A, Chen M, Reich H, Nourredin M, Nissen N, Ayoub WS. Advanced Imaging Modalities for Hepatocellular Carcinoma: Is MRI with EOVIST Really Better? Austin J Gastroenterol 2016;3(3):1-6.

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