Prof. Nicolas Girard joined us at the European Lung Cancer Conference (ELCC) 2025 to share his views on the latest data on oncogene-addicted non-small cell lung cancer (NSCLC) presented at the congress. 

 

Prof. Girard reviews data from the following studies: 

 

  • SOHO-01: Phase 1/2 SOHO-01 study of BAY 2927088 in patients with previously treated HER2-mutant NSCLC: Safety and efficacy results from 2 expansion cohorts. Girard N, et al. Abstract 3O, ELCC 2025
  • MARIPOSA: Amivantamab plus lazertinib vs osimertinib in first-line EGFR-mutant advanced NSCLC: Final overall survival from the Phase 3 MARIPOSA study. Chih-Hsin Yang J, et al. Abstract 4O, ELCC 2025
  • COCOON: Preventing moderate to severe dermatologic adverse events in first-line EGFR-mutant advanced NSCLC treated with amivantamab plus lazertinib: Early success of the COCOON trial. Girard N, et al. Abstract 10MO, ELCC 2025
  • SAVANNAH: Savolitinib + osimertinib in patients with EGFRm advanced NSCLC and MET overexpression and/or amplification following progressive disease on osimertinib. Ahn M-J, et al. Abstract 2O, ELCC 2025
  • ORCHARD: Osimertinib + datopotamab deruxtecan in patients with EGFR-mutated advanced NSCLC whose disease progressed on first-line osimertinib: ORCHARD. Le X, et al. Abstract 1O, ELCC 2025
  • DESTINY-Lung03: Phase 1b open-label study of trastuzumab deruxtecan + rilvegostomig ± carboplatin as first-line treatment for metastatic HER2-overexpressing NSCLC: DESTINY-Lung03 (DL-03) Part 4. Planchard D, et al. 132TiP, ELCC 2025

 

Watch his short summary video and download the accompanying slides for a more detailed update. 

 

Clinical takeaways

  • SOHO-01: Treatment with BAY 2927088 led to durable responses in HER2m NSCLC patients naïve to HER2-targeted therapy and in those who had received a HER2-targeted ADC
  • MARIPOSA: A highly meaningful and practice changing OS benefit was observed, further establishing amivantamab plus lazertinib as a new standard of care in patients with first-line EGFRm advanced NSCLC
  • COCOON: Early onset AEs experienced with amivantamab plus lazertinib treatment can be significantly reduced with proactive prophylactic approaches
  • SAVANNAH: Savolitinib plus osimertinib may offer a chemotherapy-free treatment option in patients with EGFRm, MET overexpressed and/or amplified advanced NSCLC after progression on osimertinib
  • ORCHARD: Osimertinib plus Dato-DXd showed promising efficacy and manageable safety in patients with EGFRm advanced NSCLC who progressed on first-line osimertinib
  • DESTINY-Lung03: a trial in progress investigating T-DXd plus rilvegostomig ± carboplatin as first-line therapy for resectable, advanced or metastatic HER2-overexpressing NSCLC
  • Understand the clinical trial data and emerging profiles of therapies for the treatment of molecularly driven lung cancer, including treatments for HER2-directed NSCLC

Nicolas Girard is a pneumologist specialising in thoracic oncology, for the treatment of patients with lung cancer or rare thoracic cancers. His expertise ranges from the development of perioperative strategies in resectable tumors, to the management of locally-advanced disease and oncogene-addicted tumors, especially EGFR-mutant NSCLC. 

Nicolas Girard is involved in several clinical and translational research projects aiming at improving the treatment of these cancers. 

He is Professor of Respiratory Medicine at Versailles Saint Quentin University, Paris Saclay Campus. He is the Head of the Curie-Montsouris Thorax Institute, and Chair of Medical Oncology Departement at Institut Curie in Paris.

Nicolas Girard co-authored more than 300 articles in peer-reviewed journals.

Prof. Nicolas Girard has received financial support/sponsorship for research support, consultation, or speaker fees from the following companies:

Research grants/support from Abbvie, Amgen, AstraZeneca, Beigene, Boehringer  Ingelheim, Bristol Myers Squibb, Daiichi-Sankyo, Gilead, Hoffmann-La Roche, Janssen,  Leo Pharma, Lilly, Merk Serono, Merck Sharp & Dohme, Novartis, Sanofi and Sivan.

Consultative services for Abbvie,  Amgen, AstraZeneca, Beigene, Bristol Myers Squibb, Daiichi-Sankyo, Gilead, Ipsen  Hoffmann-La Roche, Janssen, Leo Pharma, Lilly, Merck Sharp & Dohme, Mirati, Novartis, Pfizer,  Pierre Fabre, Sanofi and Takeda.

Participation on a data safety monitoring board for Hoffmann-La Roche.

Employment of a family member with AstraZeneca.

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