In this micro learning module developed by experts Dr Devika Das and Dr Tom Newsom-Davis, you will learn about the rapidly changing treatment landscape for patients with HER2-mutant non-small cell lung cancer (NSCLC). 

 

This module features a concise animated video, downloadable resources, and an assessment to evaluate your understanding. 

 

Topics include: 

  • The importance of early identification of HER2-mutant NSCLC and the clinical significance of these alterations 
  • Clinical trial evidence for HER2-targeted therapies, including antibody-drug conjugates and next-generation tyrosine kinase inhibitors  
  • Safety profiles and toxicity management strategies for HER2-directed treatments  
  • Evolving treatment landscape, including sequencing and emerging therapeutic approaches 

 

Micro learning programmes offer concise, easily digestible resources, each lasting under five minutes to watch or read. If you have extra time, complete the short assessment and earn CME credit in just 30 minutes.  

 

 

Clinical takeaways

  • Test early and accurately: Next generation sequencing (NGS) is required to identify HER2 mutations and guide therapy 
  • Targeted therapies improve outcomes: Antibody-drug conjugates (ADCs), such as trastuzumab deruxtecan and next-generation tyrosine kinase inhibitors (TKIs) (zongertinib, sevabertinib), show high response rates, durable responses, and activity in patients with brain metastases 
  • Manage toxicities proactively: ADCs carry interstitial lung disease risk; TKIs mainly cause low-grade diarrhea and rash, manageable with supportive care and dose adjustments 
  • Thoughtful sequencing of HER2-targeted therapies: may help optimise outcomes, particularly when used earlier in the treatment pathway, considering central nervous system involvement, efficacy, safety, and patient factors
  • Understand the latest clinical trial data and emerging profiles of therapies for the treatment of HER2-mutant NSCLC 
  • Know the potential toxicities of treatments for HER2-mutant NSCLC and how to manage for optimal outcomes
  • Recognise the appropriate placement of therapies for the treatment of HER2-mutant NSCLC across the patient journey 

I am a board-certified hematologist and medical oncologist at UF Health, with 12 years of experience in academia and community oncology practice. It is my goal to apply both research and science toward providing equitable lung cancer care. I believe in providing the highest quality of care for patients-like I would want for myself and my loved ones.

 

I previously served as the section chief of oncology at the Birmingham VA Medical Center. I was also principal investigator for the lung precision oncology programme for veterans and served as the site director for the state veterans’ lung cancer screening program, along with other leadership roles.

 

I have experience as a medical educator, having served as a fellowship site director and associate fellowship program director, among other roles in health care education.

 

My research interests include designing and implementing high-quality clinical trials that are equitable and patient-centric, with a focus on enrolling those who are historically underrepresented in medicine.

 

Most recently, I was medical director for solid tumor oncology trials with Parexel and am currently an associate professor of medicine, disease group lead for thoracic oncology, and division director of quality and safety at the University of Florida in Gainesville. In this role, I focus on delivering the highest-quality clinical trials in lung cancer and enhancing the implementation of the lung cancer screening programme.

Dr Devika Das has received financial support/sponsorship for research support, consultation, or speaker fees from the following companies:

Boehringer Ingelheim

Dr Thomas Newsom-Davis BSc MBBS FRCP, PhD

 

Tom Newsom-Davis is a consultant thoracic medical oncologist at Chelsea and Westminster Hospital, London, and an Honorary Consultant at the Royal Brompton Hospital, London.  

 

Dr Newsom-Davis has an active clinical trials portfolio. He has been UK Chief Investigator for a number of studies, as well as chairing Independent Data Monitoring Committees and sitting on trial steering groups. He has published over 70 papers and presented more than 120 abstracts in national and international meetings.

 

Dr Newsom-Davis joined the steering committee of the British Thoracic Oncology Group (BTOG) in 2017, as was elected Chair in 2025. He serves on the Multidisciplinary Clinical Science Committee of the International Association for the Study of Lung Cancer (IASLC), on the Oncology Council of the Royal Society of Medicine, and as an invited clinic expert for NICE. Dr Newsom-Davis is past Chair of the RM Partners Cancer Alliance Lung group, and past member of the NCRI Lung Cancer Clinical Studies Group.

 

He has been an invited lecturer for various organisations including the Royal College of Physicians, European Society of Medical Oncology (ESMO), IASLC, British Medical Association and the Association of Cancer Physicians. He has been a faculty member for ESMO and IASLC. His work on Acute Diagnostic Oncology Clinics has previously been awarded a Macmillan Innovation Excellence Award.

Dr Tom Newsom-Davis has received financial support/sponsorship for research support, consultation, or speaker fees from the following companies:

Support to attend educational conferences:

Abbvie, BMS, Boehringer Ingelheim, Brainomix, Johnson & Johnson, Lilly, MSD, Pfizer, Roche, Takeda

 

Consulting / Advisory Fees:

Abbvie, Accord, Amgen, Astra-Zeneca, Bayer, BMS, Boehringer Ingelheim, Daiichi Sankyo, EQRx, Gilead, GSK, Johnson & Johnson, Lilly, Merck, MSD, Novartis, Novocure, Pfizer, Regeneron, Roche, Sanofi, Takeda

 

Lectures / Public Speaking:

Accord, Amgen, Astra-Zeneca, Bayer, BMS, Boehringer Ingelheim, EQRx, GenesisCare, Gilead, Goldman Sachs, GSK, Janssen, Lilly, MSD, Novartis, Roche, Takeda

 

Clinical Trial Steering Committee / IDMC:

Astra Zeneca, MSD, Roche

In this micro learning module developed by experts Dr Devika Das and Dr Tom Newsom-Davis, you will learn about the rapidly changing treatment landscape for patients with HER2-mutant non-small cell lung cancer (NSCLC). 

 

This module features a concise animated video, downloadable resources, and an assessment to evaluate your understanding. 

 

Topics include: 

  • The importance of early identification of HER2-mutant NSCLC and the clinical significance of these alterations 
  • Clinical trial evidence for HER2-targeted therapies, including antibody-drug conjugates and next-generation tyrosine kinase inhibitors  
  • Safety profiles and toxicity management strategies for HER2-directed treatments  
  • Evolving treatment landscape, including sequencing and emerging therapeutic approaches 

 

Micro learning programmes offer concise, easily digestible resources, each lasting under five minutes to watch or read. If you have extra time, complete the short assessment and earn CME credit in just 30 minutes.  

 

 

Clinical takeaways

  • Test early and accurately: Next generation sequencing (NGS) is required to identify HER2 mutations and guide therapy 
  • Targeted therapies improve outcomes: Antibody-drug conjugates (ADCs), such as trastuzumab deruxtecan and next-generation tyrosine kinase inhibitors (TKIs) (zongertinib, sevabertinib), show high response rates, durable responses, and activity in patients with brain metastases 
  • Manage toxicities proactively: ADCs carry interstitial lung disease risk; TKIs mainly cause low-grade diarrhea and rash, manageable with supportive care and dose adjustments 
  • Thoughtful sequencing of HER2-targeted therapies: may help optimise outcomes, particularly when used earlier in the treatment pathway, considering central nervous system involvement, efficacy, safety, and patient factors
  • Understand the latest clinical trial data and emerging profiles of therapies for the treatment of HER2-mutant NSCLC 
  • Know the potential toxicities of treatments for HER2-mutant NSCLC and how to manage for optimal outcomes
  • Recognise the appropriate placement of therapies for the treatment of HER2-mutant NSCLC across the patient journey 

I am a board-certified hematologist and medical oncologist at UF Health, with 12 years of experience in academia and community oncology practice. It is my goal to apply both research and science toward providing equitable lung cancer care. I believe in providing the highest quality of care for patients-like I would want for myself and my loved ones.

 

I previously served as the section chief of oncology at the Birmingham VA Medical Center. I was also principal investigator for the lung precision oncology programme for veterans and served as the site director for the state veterans’ lung cancer screening program, along with other leadership roles.

 

I have experience as a medical educator, having served as a fellowship site director and associate fellowship program director, among other roles in health care education.

 

My research interests include designing and implementing high-quality clinical trials that are equitable and patient-centric, with a focus on enrolling those who are historically underrepresented in medicine.

 

Most recently, I was medical director for solid tumor oncology trials with Parexel and am currently an associate professor of medicine, disease group lead for thoracic oncology, and division director of quality and safety at the University of Florida in Gainesville. In this role, I focus on delivering the highest-quality clinical trials in lung cancer and enhancing the implementation of the lung cancer screening programme.

Dr Devika Das has received financial support/sponsorship for research support, consultation, or speaker fees from the following companies:

Boehringer Ingelheim

Dr Thomas Newsom-Davis BSc MBBS FRCP, PhD

 

Tom Newsom-Davis is a consultant thoracic medical oncologist at Chelsea and Westminster Hospital, London, and an Honorary Consultant at the Royal Brompton Hospital, London.  

 

Dr Newsom-Davis has an active clinical trials portfolio. He has been UK Chief Investigator for a number of studies, as well as chairing Independent Data Monitoring Committees and sitting on trial steering groups. He has published over 70 papers and presented more than 120 abstracts in national and international meetings.

 

Dr Newsom-Davis joined the steering committee of the British Thoracic Oncology Group (BTOG) in 2017, as was elected Chair in 2025. He serves on the Multidisciplinary Clinical Science Committee of the International Association for the Study of Lung Cancer (IASLC), on the Oncology Council of the Royal Society of Medicine, and as an invited clinic expert for NICE. Dr Newsom-Davis is past Chair of the RM Partners Cancer Alliance Lung group, and past member of the NCRI Lung Cancer Clinical Studies Group.

 

He has been an invited lecturer for various organisations including the Royal College of Physicians, European Society of Medical Oncology (ESMO), IASLC, British Medical Association and the Association of Cancer Physicians. He has been a faculty member for ESMO and IASLC. His work on Acute Diagnostic Oncology Clinics has previously been awarded a Macmillan Innovation Excellence Award.

Dr Tom Newsom-Davis has received financial support/sponsorship for research support, consultation, or speaker fees from the following companies:

Support to attend educational conferences:

Abbvie, BMS, Boehringer Ingelheim, Brainomix, Johnson & Johnson, Lilly, MSD, Pfizer, Roche, Takeda

 

Consulting / Advisory Fees:

Abbvie, Accord, Amgen, Astra-Zeneca, Bayer, BMS, Boehringer Ingelheim, Daiichi Sankyo, EQRx, Gilead, GSK, Johnson & Johnson, Lilly, Merck, MSD, Novartis, Novocure, Pfizer, Regeneron, Roche, Sanofi, Takeda

 

Lectures / Public Speaking:

Accord, Amgen, Astra-Zeneca, Bayer, BMS, Boehringer Ingelheim, EQRx, GenesisCare, Gilead, Goldman Sachs, GSK, Janssen, Lilly, MSD, Novartis, Roche, Takeda

 

Clinical Trial Steering Committee / IDMC:

Astra Zeneca, MSD, Roche

In this micro learning module developed by experts Dr Devika Das and Dr Tom Newsom-Davis, you will learn about the rapidly changing treatment landscape for patients with HER2-mutant non-small cell lung cancer (NSCLC). 

 

This module features a concise animated video, downloadable resources, and an assessment to evaluate your understanding. 

 

Topics include: 

  • The importance of early identification of HER2-mutant NSCLC and the clinical significance of these alterations 
  • Clinical trial evidence for HER2-targeted therapies, including antibody-drug conjugates and next-generation tyrosine kinase inhibitors  
  • Safety profiles and toxicity management strategies for HER2-directed treatments  
  • Evolving treatment landscape, including sequencing and emerging therapeutic approaches 

 

Micro learning programmes offer concise, easily digestible resources, each lasting under five minutes to watch or read. If you have extra time, complete the short assessment and earn CME credit in just 30 minutes.  

 

 

Clinical takeaways

  • Test early and accurately: Next generation sequencing (NGS) is required to identify HER2 mutations and guide therapy 
  • Targeted therapies improve outcomes: Antibody-drug conjugates (ADCs), such as trastuzumab deruxtecan and next-generation tyrosine kinase inhibitors (TKIs) (zongertinib, sevabertinib), show high response rates, durable responses, and activity in patients with brain metastases 
  • Manage toxicities proactively: ADCs carry interstitial lung disease risk; TKIs mainly cause low-grade diarrhea and rash, manageable with supportive care and dose adjustments 
  • Thoughtful sequencing of HER2-targeted therapies: may help optimise outcomes, particularly when used earlier in the treatment pathway, considering central nervous system involvement, efficacy, safety, and patient factors
  • Understand the latest clinical trial data and emerging profiles of therapies for the treatment of HER2-mutant NSCLC 
  • Know the potential toxicities of treatments for HER2-mutant NSCLC and how to manage for optimal outcomes
  • Recognise the appropriate placement of therapies for the treatment of HER2-mutant NSCLC across the patient journey 

I am a board-certified hematologist and medical oncologist at UF Health, with 12 years of experience in academia and community oncology practice. It is my goal to apply both research and science toward providing equitable lung cancer care. I believe in providing the highest quality of care for patients-like I would want for myself and my loved ones.

 

I previously served as the section chief of oncology at the Birmingham VA Medical Center. I was also principal investigator for the lung precision oncology programme for veterans and served as the site director for the state veterans’ lung cancer screening program, along with other leadership roles.

 

I have experience as a medical educator, having served as a fellowship site director and associate fellowship program director, among other roles in health care education.

 

My research interests include designing and implementing high-quality clinical trials that are equitable and patient-centric, with a focus on enrolling those who are historically underrepresented in medicine.

 

Most recently, I was medical director for solid tumor oncology trials with Parexel and am currently an associate professor of medicine, disease group lead for thoracic oncology, and division director of quality and safety at the University of Florida in Gainesville. In this role, I focus on delivering the highest-quality clinical trials in lung cancer and enhancing the implementation of the lung cancer screening programme.

Dr Devika Das has received financial support/sponsorship for research support, consultation, or speaker fees from the following companies:

Boehringer Ingelheim

Dr Thomas Newsom-Davis BSc MBBS FRCP, PhD

 

Tom Newsom-Davis is a consultant thoracic medical oncologist at Chelsea and Westminster Hospital, London, and an Honorary Consultant at the Royal Brompton Hospital, London.  

 

Dr Newsom-Davis has an active clinical trials portfolio. He has been UK Chief Investigator for a number of studies, as well as chairing Independent Data Monitoring Committees and sitting on trial steering groups. He has published over 70 papers and presented more than 120 abstracts in national and international meetings.

 

Dr Newsom-Davis joined the steering committee of the British Thoracic Oncology Group (BTOG) in 2017, as was elected Chair in 2025. He serves on the Multidisciplinary Clinical Science Committee of the International Association for the Study of Lung Cancer (IASLC), on the Oncology Council of the Royal Society of Medicine, and as an invited clinic expert for NICE. Dr Newsom-Davis is past Chair of the RM Partners Cancer Alliance Lung group, and past member of the NCRI Lung Cancer Clinical Studies Group.

 

He has been an invited lecturer for various organisations including the Royal College of Physicians, European Society of Medical Oncology (ESMO), IASLC, British Medical Association and the Association of Cancer Physicians. He has been a faculty member for ESMO and IASLC. His work on Acute Diagnostic Oncology Clinics has previously been awarded a Macmillan Innovation Excellence Award.

Dr Tom Newsom-Davis has received financial support/sponsorship for research support, consultation, or speaker fees from the following companies:

Support to attend educational conferences:

Abbvie, BMS, Boehringer Ingelheim, Brainomix, Johnson & Johnson, Lilly, MSD, Pfizer, Roche, Takeda

 

Consulting / Advisory Fees:

Abbvie, Accord, Amgen, Astra-Zeneca, Bayer, BMS, Boehringer Ingelheim, Daiichi Sankyo, EQRx, Gilead, GSK, Johnson & Johnson, Lilly, Merck, MSD, Novartis, Novocure, Pfizer, Regeneron, Roche, Sanofi, Takeda

 

Lectures / Public Speaking:

Accord, Amgen, Astra-Zeneca, Bayer, BMS, Boehringer Ingelheim, EQRx, GenesisCare, Gilead, Goldman Sachs, GSK, Janssen, Lilly, MSD, Novartis, Roche, Takeda

 

Clinical Trial Steering Committee / IDMC:

Astra Zeneca, MSD, Roche

Programme summary
Share this programme
This educational programme is supported by an Independent Educational Grant from Bayer
Supporter Acknowledgement
This educational programme is supported by an Independent Educational Grant from Bayer
Endorsement
I agree that this educational programme:

Was valuable to me

1/4
Brought to you by
LUNG CONNECT

LUNG CONNECT is an initiative of COR2ED, supported by Independent Educational Grants from Bayer, Pierre Fabre Laboratories, Boehringer Ingelheim, Eisai Pharma AG, Revolution Medicines, and AstraZeneca.

Meet the experts
Brought to you by
PRECISION ONCOLOGY CONNECT

PRECISION ONCOLOGY CONNECT is an initiative of COR2ED, supported by Independent Educational Grants from AstraZeneca, Amoy Diagnostics, Bayer, Pierre Fabre Laboratories, Thermo Fisher Scientific and Daiichi Sankyo.

Meet the experts Independent IME approved
Programme summary
Share this programme
This educational programme is supported by an Independent Educational Grant from Bayer
Supporter Acknowledgement
This educational programme is supported by an Independent Educational Grant from Bayer
Endorsement
I agree that this educational programme:

Was valuable to me

1/4
Brought to you by
LUNG CONNECT

LUNG CONNECT is an initiative of COR2ED, supported by Independent Educational Grants from Bayer, Pierre Fabre Laboratories, Boehringer Ingelheim, Eisai Pharma AG, Revolution Medicines, and AstraZeneca.

Meet the experts
Brought to you by
PRECISION ONCOLOGY CONNECT

PRECISION ONCOLOGY CONNECT is an initiative of COR2ED, supported by Independent Educational Grants from AstraZeneca, Amoy Diagnostics, Bayer, Pierre Fabre Laboratories, Thermo Fisher Scientific and Daiichi Sankyo.

Meet the experts Independent IME approved
Programme summary
Share this programme
This educational programme is supported by an Independent Educational Grant from Bayer
Supporter Acknowledgement
This educational programme is supported by an Independent Educational Grant from Bayer
Endorsement
I agree that this educational programme:

Was valuable to me

1/4
Brought to you by
LUNG CONNECT

LUNG CONNECT is an initiative of COR2ED, supported by Independent Educational Grants from Bayer, Pierre Fabre Laboratories, Boehringer Ingelheim, Eisai Pharma AG, Revolution Medicines, and AstraZeneca.

Meet the experts
Brought to you by
PRECISION ONCOLOGY CONNECT

PRECISION ONCOLOGY CONNECT is an initiative of COR2ED, supported by Independent Educational Grants from AstraZeneca, Amoy Diagnostics, Bayer, Pierre Fabre Laboratories, Thermo Fisher Scientific and Daiichi Sankyo.

Meet the experts Independent IME approved

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