We are pleased to share a new 3-part video series on best practices in managing early relapsed/refractory multiple myeloma (RRMM). Navigate between videos using the tabs.

Each video features a renowned medical expert and has an accompanying slide set for download.

 

We are pleased to share a new 3-part video series on best practices in managing early relapsed/refractory multiple myeloma (RRMM). Navigate between videos using the tabs.

Each video features a renowned medical expert and has an accompanying slide set for download. 

 

We are pleased to share a new 3-part video series on best practices in managing early relapsed/refractory multiple myeloma (RRMM). Navigate between videos using the tabs.

Each video features a renowned medical expert and has an accompanying slide set for download. 

 

Although therapeutic advances in multiple myeloma have improved patient outcomes, this has generated a wide range of patient profiles at early relapse.

  

Dr Elena Zamagni summarises the unmet medical needs in earlier relapses in multiple myeloma, including: 

 

  • The current treatment landscape and challenges 
  • Current guidelines and recommendations 
  • The need for new targets/therapies with different mechanisms of actions 

 

Clinical takeaways

 

  • Current guidelines recommend lenalidomide-based treatment in the frontline setting
  • Non-transplant eligible patients may become anti-CD38 refractory after one prior line of therapy
  • Although therapeutic advances in MM have improved outcomes, this has generated a wide range of patient profiles at early relapse, many with substantial unmet needs
  • There is a need for new targets/new drugs with different mechanisms of action
  • SVd may be a suitable treatment option for early relapsed patients previously treated with lenalidomide and daratumumab, as it offers a double MoA switch
  • Know how to incorporate the latest scientific and clinical insights on the treatment of multiple myeloma into clinical practice, focusing on the relapsed/refractory setting
  • Knowing the MoA and how this translates into the efficacy profile of novel drugs
  • Learning from best practices on treatment sequencing, treatment combinations, and dosing in multiple myeloma
  • Knowing the safety profiles of novel drugs and what the best strategies are to prevent or act on side effects

Elena Zamagni MD, PHD, is Associate Professor of Hematology at the Bologna University, Italy. She received her medical degree from University of Bologna, where she also served her residency in haematology. She got PHD in Clinical Hematology at the University of Bologna in May 2005.

Her research interests include areas related to multiple myeloma, in particular on the role of high dose therapy with stem cell support, of prognostic factors, minimal residual disease and of imaging techniques.

She has published over 150 papers in peer-reviewed journals, mainly in the field of plasma cell dyscrasia. She has contributed to the educational session of the Italian Society of Haematology (SIE) and American Society of Clinical Oncology (ASCO). She is abstracts reviewer for SIE, EHA and ASH. She is part of the editorial board of several haematological journals, including Blood Cancer Journal and Journal of Clinical Oncology. She is an active member of the board of the GIMEMA and European Myeloma Network (EMN) working party and she has cooperated in the Scientific secretary and as principal investigator in several national randomized trials in multiple myeloma. She is a member of the Italian Society of Haematology, of the International Myeloma Working Group and of the International Myeloma Society. She is served on the EHA’s Scientific Program Committee from 2017 to 2021. She is part of the Scientific Program Committee for the European Society of Clinical Oncology since 2021. She is responsible for the career development committee within the International Myeloma Society since 2019 and member of the board of the IMS as European representative since 2023.

Dr Elena Zamagni has received financial support/sponsorship for research support, consultation, or speaker fees from the following companies:

Janssen, BMS, Amgen, Pfizer, GSK & Sanofi

Multiple myeloma is highly heterogeneous from diagnosis, which makes it a complex disease.

 

Dr Fredrik Schjesvold explores the importance of adding a new Mechanism of Action (MoA) in relapsed/refractory multiple myeloma (RRMM), focusing on:

 

  • The heterogeneity at diagnosis, as the heterogenic clones vary in their sensitivity to different treatments, and genomic aberrations and drug sensitivity 
  • The impact of changing and adding drug classes in relapse treatment 

 

Clinical Takeaways

  • Multiple myeloma is a highly heterogeneous disease from diagnosis
  • The heterogeneic clones vary in their sensitivity to different treatments. Therefore, combinations are preferable
  • Each new treatment should preferably include drugs with novel mechanisms of action, which is more important when multiple myeloma becomes refractory rather than just exposed
  • Know how to incorporate the latest scientific and clinical insights on the treatment of multiple myeloma into clinical practice, focusing on the relapsed/refractory setting 
  • Knowing the MoA and how this translates into the efficacy profile of novel drugs 
  • Learning from best practices on treatment sequencing, treatment combinations and dosing in multiple myeloma
  • Knowing the safety profiles of novel drugs and what the best strategies are to prevent or act on side effects 

Fredrik Schjesvold is Head of Oslo Myeloma Center, in Oslo, Norway. He is head of the Norwegian myeloma association; president elect of the Nordic Myeloma Study Group and a member of the European Myeloma Network young board. He is national investigator of 36 clinical trials in multiple myeloma, and principal investigator for 4 academic trials. He is a co-author of ESMO and IMWG guidelines, as well as lead author of the Norwegian myeloma guidelines. He is peer reviewer of several international journals, and co-editor of the journal Hemato. He is an international expert on myeloma and has given talks in Europe, America and Asia.

Dr Fredrik Schjesvold has received financial support/sponsorship for research support, consultation, or speaker fees from the following companies:

Targovax, Amgen, BMS, Takeda, Sanofi, Menarini, Abbvie, Janssen, Oncopeptides, GSK & Regeneron

The world of multiple myeloma has changed considerably over the last several years and, in particular, in early relapse. There are more treatment options than ever before.

 

Dr Joseph Mikhael discusses current best practices in treating patients with multiple myeloma in the early relapsed/refractory setting and explores:

  • Different treatment sequences, combinations and dosing in multiple myeloma
  • His experience with XPO1 inhibitors and his approach to managing side effects

 

Clinical takeaways

  • The treatment landscape for early relapsed multiple myeloma is expanding, including CAR-T cell therapies now available (prioritised for functional high-risk patients)
  • Early relapse management involves several drug classes:
    • Immunomodulatory agents, proteasome inhibitors, monoclonal antibodies, XPO1 inhibitors
  • Selinexor is a first-in-class XPO1 inhibitor. Side effects can be managed through dose modifications and with the use of antiemetics
  • General principles of therapy selection include:
    • Introducing a new mechanism of action
    • Using a triplet combination
    • Selecting the best combination based on patient, disease and treatment characteristics
  • Know how to incorporate the latest scientific and clinical insights on the treatment of multiple myeloma into clinical practice, focusing on the relapsed/refractory setting 
  • Knowing the MoA and how this translates into the efficacy profile of novel drugs 
  • Learning from best practices on treatment sequencing, treatment combinations and dosing in multiple myeloma 
  • Knowing the safety profiles of novel drugs and what the best strategies are to prevent or act on side effects 

Dr Joseph Mikhael has received financial support/sponsorship for research support, consultation, or speaker fees from the following companies:

Amgen, BMS, Janssen & Sanofi

Programme summary
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This educational programme is supported by an Independent Educational Grant from Menarini Stemline Oncology.
Supporter Acknowledgement
This educational programme is supported by an Independent Educational Grant from Menarini Stemline Oncology.
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Brought to you by
LYMPHOMA & MYELOMA CONNECT

LYMPHOMA & MYELOMA CONNECT is an initiative of COR2ED, supported by Independent Educational Grants from Bayer, Karyopharm Therapeutics and Menarini Stemline Oncology.

Meet the experts Independent IME approved
Programme summary
Watch the video now
Share this programme
This educational programme is supported by an Independent Educational Grant from Menarini Stemline Oncology.
Supporter Acknowledgement
This educational programme is supported by an Independent Educational Grant from Menarini Stemline Oncology.
I agree that this educational programme:

Was valuable to me

1/4
Brought to you by
LYMPHOMA & MYELOMA CONNECT

LYMPHOMA & MYELOMA CONNECT is an initiative of COR2ED, supported by Independent Educational Grants from Bayer, Karyopharm Therapeutics and Menarini Stemline Oncology.

Meet the experts Independent IME approved
Programme summary
Watch the video now
Share this programme
This educational programme is supported by an Independent Educational Grant from Menarini Stemline Oncology.
Supporter Acknowledgement
This educational programme is supported by an Independent Educational Grant from Menarini Stemline Oncology.
I agree that this educational programme:

Was valuable to me

1/4
Brought to you by
LYMPHOMA & MYELOMA CONNECT

LYMPHOMA & MYELOMA CONNECT is an initiative of COR2ED, supported by Independent Educational Grants from Bayer, Karyopharm Therapeutics and Menarini Stemline Oncology.

Meet the experts Independent IME approved

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