Listen and follow our podcasts on:

This educational programme is supported by an Independent Medical Education Grant from Karyopharm

In this second episode, Dr. Joshua Richter and Dr. Karthik Ramasamy discuss their views on choosing the best treatment regimen in relapsed/refractory multiple myeloma (RRMM)


Episode 2 – The Relapsed/Refractory Setting

 

In the second episode, Dr. Richter and Dr. Ramasamy explore how to select the best treatment approach in the second-line setting and beyond. They discuss at what point they consider a patient to actually be in relapse. The decision on which treatment option to select in the second-line and beyond mostly depends on refractoriness to other drugs. With an increasing number of novel treatment options, choosing a regimen that does not include a drug the patient is refractory to is becoming easier. However, many challenges remain when making these treatment decisions. The experts share their experiences with CAR-T and other T cell redirection therapies, and when to use it in the treatment sequence, concluding with a look into the future of myeloma treatment.

 

In the first podcast episode, Dr. Joshua Richter and Dr. Karthik Ramasamy discuss how to select the best approach in newly diagnosed patients with MM. They discuss personalising therapy, both in the transplant setting as well as in patients who are not eligible for transplantation. They also consider the impact of MRD negativity in clinical practice. The experts agree that the goal of treatment is to induce deep remissions and debate whether triple or quadruplet therapy is required to achieve this goal. The final topic that the experts discuss is continuous vs fixed-duration maintenance therapy.

 

In the third podcast episode, Dr. María Victoria Mateos and Dr. Alexander Lesokhin discuss how they choose the best treatment regimen for patients with multiple myeloma and a high-risk cytogenetic profile. They discuss the treatment options available for patients with high-risk cytogenetics in the US and in Europe and the factors they consider in these decisions in their clinical practice. Although the prior treatment is the most important consideration in the relapsed setting, the type of cytogenetic abnormality also plays a role. The experts specifically discuss treatment decisions in patients with extramedullary multiple myeloma: a difficult-to-treat population. The future of myeloma treatment is also explored, looking at trial design to better meet the needs of patients with a high-risk cytogenetic profile and the role of CAR-T and bispecific antibodies in this population.

 

This LYMPHOMA & MYELOMA CONNECT podcast series is also available on Castos, Spotify, Apple Podcasts, and Google Podcasts.

Karthik Ramasamy is a Consultant Haematologist at Oxford University Hospitals NHS Trust and Associate Professor of Haematology, Radcliffe Department of Medicine, Oxford UK. Dr Ramasamy is the Director of the Oxford Myeloma Translational Research Centre, and a Lead Clinician for myeloma and other plasma cell dyscrasias at the Thames Valley Cancer Alliance Group. He is the Divisional Lead for Cancer research for National Institute for Health Research, Clinical Research Network Thames Valley and South Midlands, UK. He is an executive member of the UK Myeloma Forum and is an active member of UK Myeloma Research Alliance. Karthik serves on the Myeloma UK Board, a patient charity exclusively dealing with myeloma advocacy and research. Dr Ramasamy completed his haematology training in London. Following this, he completed three years as a clinical research fellow working on bone marrow microenvironment in myeloma at King’s College London. Dr Ramasamy is a Chief Investigator of myeloma studies and his translational research interests are early diagnosis of myeloma, myeloma renal, bone disease and myeloma drug resistance mechanisms. Karthik has published over 50 papers and authored textbooks/ chapters on myeloma

Assoc. Prof. Karthik Ramasamy has received financial support/sponsorship for research support, consultation, or speaker fees from the following companies:

Amgen, Adaptive, BMS, Biotech, GSK, Janssen, Karyopharm, Oncopeptides, Pfizer and Takeda. 

Joshua Richter, M.D., is an Associate Professor in the Myeloma Division at the Tisch Cancer Institute at the Icahn School of Medicine at Mount Sinai and the Director of Myeloma at the Blavatnik Family Chelsea Medical Center at Mount Sinai.  He completed undergraduate work at Johns Hopkins University and subsequently went on to medical school at New York Medical College. He completed residency at St. Vincent’s Hospital – New York Medical College.  Dr Richter completed his hematology/oncology fellowship at the Yale Cancer Center.  After completing fellowship he worked in the myeloma division at the John Theurer Cancer Center at Hackensack University Medical.  In 2018 he joined the Myeloma Division at Mount Sinai Hospital.   Dr Richter has been published in numerous oncology journals including NEJM, Blood, and the Journal of Clinical Oncology.   He has an interest in immunotherapy, multi-functional antibodies and precision medicine.

Assoc. Prof. Joshua Richter has received financial support/sponsorship for research support, consultation, or speaker fees from the following companies:

Adaptive Biotechnologies, AstraZeneca, BMS, Celgene, Janssen, Karyopharm, Oncopeptides, Secura Bio, Sanofi and X4 Pharmaceuticals. 

Programme summary
Listen to the podcast now
Other episodes in this series
Choosing the Best Treatment Regimen in NDMM

Choosing the Best Treatment Regimen in NDMM

Episode 1: Choosing the Best Treatment Regimen in NDMM

Choosing the Best Treatment Regimen in RRMM

Choosing the Best Treatment Regimen in RRMM

Episode 2: Choosing the Best Treatment Regimen in RRMM

Current Episode
Choosing the Best Treatment Regimen in Patients with High-Risk Cytogenetics

Choosing the Best Treatment Regimen in Patients with High-Risk Cytogenetics

Episode 3: Choosing the Best Treatment Regimen in Patients with High-Risk Cytogenetics

Share this programme
This educational programme is supported by an Independent Medical Education Grant from Karyopharm
I agree that this educational programme:

Was valuable to me

1/4
Brought to you by
LYMPHOMA & MYELOMA CONNECT

LYMPHOMA & MYELOMA CONNECT is an initiative of COR2ED, supported by an Independent Educational Grant from Bayer and from Karyopharm Therapeutics.

Meet the experts

Other programmes of interest

conference-update Conference update

Episode

6

of 6

episode
Oncology Hemato-oncology 
Listen to Expert Insights on Late-Breaking Data from ASCO 2023

Episode 6: Lymphoma Update: SWOG S1826 trial

Experts
Dr Mansoor Raza Mirza, Dr Paolo Tarantino, Prof. Alexey V Danilov, Prof. Mark Socinski, Prof. Evan Yu, Prof. Thomas Powles, Assoc. Prof. Gerald Prager
  • clock 2 MIN
  • calendar Jun 2023

Oncology Hemato-oncology 
Update From ASH 2022

Highlights from the ASH Annual Meeting

Experts
Dr Matthew J. Matasar
  • clock 4 MIN
  • calendar Dec 2022

Educational programme supported by an independent medical education grant from COR2ED.
Hemato-oncology 
Update from ASCO 2022 – Myeloma

Dr Hans Lee summarises the highlights from the phase 3 DETERMINATION trial: Lenalidomide, bortezomib, and dexamethasone (RVd) ± autologous stem cell transplantation (ASCT) and R maintenance to progression for newly diagnosed multiple myeloma (NDMM)

Experts
Asst. Prof. Hans Lee
  • clock 2 MIN
  • calendar May 2022

podcast Podcast

Episode

3

of 3

episode
Hemato-oncology 
Choosing the Best Treatment Regimen in Patients with High-Risk Cytogenetics

Episode 3: Choosing the Best Treatment Regimen in Patients with High-Risk Cytogenetics

Experts
Assoc. Prof. María Victoria Mateos, Dr Alexander M Lesokhin
  • download Downloadable
    Resources
  • clock 20 MIN
  • calendar Mar 2022

Educational programme supported by an independent medical education grant from Karyopharm
Hemato-oncology 
Lymphoma Update from ASH 2021

Dr. Matthew J. Matasar summarises the highlights in lymphoma from ASH 2021, including POLARIX, CAR-T in LBCL and mosunetuzumab in FL

Experts
Dr Matthew J. Matasar
  • download Downloadable
    Resources
  • clock 5 MIN
  • calendar Dec 2021

Educational programme supported by an independent medical education grant from Bayer
Hemato-oncology 
DLBCL Review Paper Published in The Oncologist

Authored by LYMPHOMA & MYELOMA CONNECT members, the paper ‘Translating the Biology of Diffuse Large B-cell Lymphoma into Treatment’ provides an overview of recent advances in DLBCL biology and how they can be translated into clinical care.

Experts
Dr Matthew J. Matasar, Dr Massimo Magagnoli, Prof. Alexey V Danilov
  • download Downloadable
    Resources
  • clock 5 MIN
  • calendar Nov 2021

Educational programme supported by an independent medical education grant from Bayer