GI oncologists Dr Lizzy Smyth and Dr Yelena Janjigian share their reactions to new gastric/GEJ data emerging from ESMO 2026. The experts provide their perspectives on data from two late-breaking trials in Claudin 18.2-positive gastroesophageal cancer:
-
CLARITY-Gastric 01 (CG-01): a phase 3 study of sonesitatug vedotin in 2nd line+ advanced or metastatic Claudin 18.2-positive gastroesophageal carcinoma. Xu R-H, et al. Abstract LBA7, ESMO 2026
-
G-HOPE-001: First interim analysis of the randomised, open-label, phase 3 study of arcotatug tavatecan (IBI343/TAK-921) versus treatment of physician’s choice in previously treated, advanced gastric or gastroesophageal junction adenocarcinoma. Shitara K, et al. Abstract LBA77, ESMO 2026
Clinical takeaways
- CLDN18.2-directed ADCs may expand the treatment landscape in 2nd-line and beyond gastric/GEJ cancer
G-HOPE-001 demonstrated OS and PFS benefits with arcotatug tavatecan in Asian patients treated in the 3rd-line-or-later setting. Meanwhile, in CLARITY-Gastric01, sonesitatug vedotin doubled median OS in the 3rd-line-or-later population, with an OS benefit also observed in the 2nd-line-or-later population
- Broader CLDN18.2 testing and lower expression thresholds may expand eligibility for future targeted therapies
CLARITY-Gastric01 used a lower CLDN18.2 expression threshold (≥25%, any staining) than G-HOPE-001 (≥75%, moderate to strong staining intensity), highlighting the importance of routine testing and collaboration with pathologists to identify eligible patients
- Prepare for potential clinical implementation: optimise toxicity management & explore earlier lines of therapy
Clinical implementation will require proactive toxicity management. Earlier treatment may benefit patients before they become too frail, while further studies clarify optimal sequencing and combinations







Downloadable
27 MIN
Oct 2026
