In these short videos, Dr María Victoria Mateos, Dr Karthik Ramasamy, and Dr Elena Zamagni share insights from the symposium at the EHA 2025 Congress on 'Innovating relapsed refractory multiple myeloma care: Unmet needs, therapy management, and real-world experience', sponsored by Menarini Stemline. 

 

Download the accompanying slides for further insights.

 

Key topics include: 

 

  • Addressing unmet needs with a new mechanism of action: Role and place of XPO1 inhibition 
  • Streamlining therapy management: Practical strategies for enhanced treatment outcomes
  • Bridging evidence and practice: Real-world insights and clinical case discussions 

 

Clinical takeaways

 

  • Despite many novel therapeutics in R/R MM, unmet needs continue to exist, and we need to understand optimal sequencing to improve patient outcomes
  • Available options in anti-CD38- and lenalidomide-refractory patients are limited, and Kd and PVd have their own safety challenges
  • Selinexor introduces a novel MoA; the BOSTON trial validates its combination with bortezomib (SVd), and has an effective utility with double antiemetic prophylaxis and dose modifications
  • Selinexor is included in worldwide guidelines for the management of patients with myeloma after at least 1 prior line in this competitive landscape:
    • SVd showed benefit in the lenalidomide-refractory population, including survival benefit
    • SVd is a viable treatment option that allows for the preservation of BCMA-TT for later lines*
    • SVd can also be used after BCMA-TT in early lines, without compromising and potentially having a positive effect on subsequent lines of T-cell redirecting therapies*

 

*Statements not explicitly supported by or mentioned in selinexor SmPC

You will explore:

  • The continued unmet needs of patients with early relapsed refractory MM, with a focus on the role of XPO1 inhibition in addressing these challenges 
  • The latest clinical data and strategies for the therapeutic management of relapsed refractory MM 
  • Real-world experiences with selinexor-based combination regimens and their positioning in the evolving MM treatment landscape 
  • Innovative treatment approaches for enhancing care in patients with relapsed refractory MM 

Dr María-Victoria Mateos, MD, PhD, is Consultant Physician in the Haematology Department and Associate Professor of Medicine at the University of Salamanca, Spain. She is the director of the Myeloma Program and coordinates the Clinical Trials Unit in Salamanca’s University Hospital Haematology Department. She serves as coordinator of GEM (Spanish Myeloma Group), with direct involvement in the design and development of clinical trials. She has coordinated many clinical trials especially in the smouldering myeloma setting and these trials have profoundly influenced current options for the management of these patient populations. She has published over 250 original papers in international journals and her articles had received 29.452 citations (19268 since 2015) with a H index of 79 and 60 since 2015. She is also a member of the IMWG (International MM Working Group), IMS (International MM Society), EHA and ASH. Among her invited presentations, she has contributed to the educational sessions of EHA 2012, ASH 2013, ASCO 2015, EHA 2016, ASCO and ASH 2017. She has served on the ASH Scientific Committee on plasma cell diseases between 2015-2019 and on the EHA’s Scientific Program Committee and Advisory Board since 2013 until 2020 being chair of the Scientific Program Committee in 2019, and. She has been Councillor on the EHA Board since 2015 for a four-year mandate, member of the Steering Committee for the Society of Hematologic Oncology (SOHO), member of the IMS board and member of the European School of Haematology (ESH) Scientific committee. She received the Briand Durie Award in 2019 recognizing excellence in myeloma research.

In these short videos, Dr María Victoria Mateos, Dr Karthik Ramasamy, and Dr Elena Zamagni share insights from the symposium at the EHA 2025 Congress on 'Innovating relapsed refractory multiple myeloma care: Unmet needs, therapy management, and real-world experience', sponsored by Menarini Stemline. 

 

Download the accompanying slides for further insights.

 

Key topics include: 

 

  • Addressing unmet needs with a new mechanism of action: Role and place of XPO1 inhibition 
  • Streamlining therapy management: Practical strategies for enhanced treatment outcomes
  • Bridging evidence and practice: Real-world insights and clinical case discussions 

 

Clinical takeaways

 

  • Considering factors related to the patient, treatment targets, and AE profiles will help individual treatment decisions
  • Novel therapeutic options have specific toxicities such as CRS, ICANS, infections or ocular events that require careful management and follow-up
  • Selinexor’s clinical utility is maximised with double antiemetic prophylaxis and dose modifications
  • The effectiveness of T-cell therapies may depend on the status of a patient’s immune system, including T-cell fitness or exhaustion

You will explore:

  • The continued unmet needs of patients with early relapsed refractory MM, with a focus on the role of XPO1 inhibition in addressing these challenges 
  • The latest clinical data and strategies for the therapeutic management of relapsed refractory MM 
  • Real-world experiences with selinexor-based combination regimens and their positioning in the evolving MM treatment landscape
  • Innovative treatment approaches for enhancing care in patients with relapsed refractory MM 

Karthik Ramasamy is a Consultant Haematologist at Oxford University Hospitals NHS Trust and Associate Professor of Haematology, Radcliffe Department of Medicine, Oxford UK. Dr Ramasamy is the Director of the Oxford Myeloma Translational Research Centre, and a Lead Clinician for myeloma and other plasma cell dyscrasias at the Thames Valley Cancer Alliance Group. He is the Divisional Lead for Cancer research for National Institute for Health Research, Clinical Research Network Thames Valley and South Midlands, UK. He is an executive member of the UK Myeloma Forum and is an active member of UK Myeloma Research Alliance. Karthik serves on the Myeloma UK Board, a patient charity exclusively dealing with myeloma advocacy and research. Dr Ramasamy completed his haematology training in London. Following this, he completed three years as a clinical research fellow working on bone marrow microenvironment in myeloma at King’s College London. Dr Ramasamy is a Chief Investigator of myeloma studies and his translational research interests are early diagnosis of myeloma, myeloma renal, bone disease and myeloma drug resistance mechanisms. Karthik has published over 50 papers and authored textbooks/ chapters on myeloma

Assoc. Prof. Karthik Ramasamy has received financial support/sponsorship for research support, consultation, or speaker fees from the following companies:

Amgen, Adaptive, BMS, Biotech, GSK, Janssen, Karyopharm, Oncopeptides, Pfizer and Takeda. 

In these short videos, Dr María Victoria Mateos, Dr Karthik Ramasamy, and Dr Elena Zamagni share insights from the symposium at the EHA 2025 Congress on 'Innovating relapsed refractory multiple myeloma care: Unmet needs, therapy management, and real-world experience', sponsored by Menarini Stemline. 

 

Download the accompanying slides for further insights.

 

Key topics include: 

 

  • Addressing unmet needs with a new mechanism of action: Role and place of XPO1 inhibition 
  • Streamlining therapy management: Practical strategies for enhanced treatment outcomes
  • Bridging evidence and practice: Real-world insights and clinical case discussions

 

Clinical takeaways

 

  • Incorporating selinexor combinations as T-cell sparing regimens can optimise sequencing and improve outcomes following prior BCMA-targeted therapies
  • SVd demonstrated efficacy in a penta-refractory patient who had received multiple prior lines of therapy, including T-cell redirecting therapy
  • SVd has shown effectiveness as a second-line treatment after double lenalidomide and daratumumab refractoriness, and may enable subsequent use of T-cell redirecting therapies
  • The ongoing GIMEMA observational study aims to collect data on SVd in 159 patients refractory to lenalidomide, who have received 1–3 prior lines of therapy

You will explore:

  • The continued unmet needs of patients with early relapsed refractory MM, with a focus on the role of XPO1 inhibition in addressing these challenges 
  • The latest clinical data and strategies for the therapeutic management of relapsed refractory MM 
  • Real-world experiences with selinexor-based combination regimens and their positioning in the evolving MM treatment landscape
  • Innovative treatment approaches for enhancing care in patients with relapsed refractory MM 

Elena Zamagni MD, PHD, is Associate Professor of Hematology at the Bologna University, Italy. She received her medical degree from University of Bologna, where she also served her residency in haematology. She got PHD in Clinical Hematology at the University of Bologna in May 2005.

Her research interests include areas related to multiple myeloma, in particular on the role of high dose therapy with stem cell support, of prognostic factors, minimal residual disease and of imaging techniques.

She has published over 150 papers in peer-reviewed journals, mainly in the field of plasma cell dyscrasia. She has contributed to the educational session of the Italian Society of Haematology (SIE) and American Society of Clinical Oncology (ASCO). She is abstracts reviewer for SIE, EHA and ASH. She is part of the editorial board of several haematological journals, including Blood Cancer Journal and Journal of Clinical Oncology. She is an active member of the board of the GIMEMA and European Myeloma Network (EMN) working party and she has cooperated in the Scientific secretary and as principal investigator in several national randomized trials in multiple myeloma. She is a member of the Italian Society of Haematology, of the International Myeloma Working Group and of the International Myeloma Society. She is served on the EHA’s Scientific Program Committee from 2017 to 2021. She is part of the Scientific Program Committee for the European Society of Clinical Oncology since 2021. She is responsible for the career development committee within the International Myeloma Society since 2019 and member of the board of the IMS as European representative since 2023.

Assoc. Prof. Elena Zamagni has received financial support/sponsorship for research support, consultation, or speaker fees from the following companies:

Janssen, BMS, Amgen, Pfizer, GSK & Sanofi

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Programme summary
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This programme has been sponsored by Menarini Stemline and is intended for healthcare professionals only.
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I agree that this programme:

Was valuable to me

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Programme summary
Watch the video now
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This programme has been sponsored by Menarini Stemline and is intended for healthcare professionals only.
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