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This educational programme is supported by an Independent Educational Grant from Ipsen

In these two podcasts, medical experts and a patient representative share their perspectives on new Primary Biliary Cholangitis (PBC) data from EASL 2023.

In podcast 1, physicians Dr Emma Culver and Prof. Gideon Hirschfield discuss the evidence of cancer risk associated with PBC, how liver stiffness progression is associated with prognosis; and outcomes and response prediction in second-line therapy.

In podcast 2, CEO of the PBC Foundation, Robert Mitchell-Thain, and autoimmune specialist nurse Kath Houghton explore the impact of PBC symptoms and new instruments for assessing them. They also discuss data highlighting the importance of the current move toward normalisation of liver biomarkers and take a look at some early data on future therapies and therapeutic targets.

Transcripts, with details of the presentations covered, are available for download.

 

 

Clinical Takeaways

 

  • When treating people living with PBC, the goal is to aim for normal liver blood tests and normal quality of life

  • Emerging therapies are hoped to both significantly address biochemical and symptom control in PBC

  • Pruritus and fatigue can be devastating, and upcoming trials importantly are addressing alleviation of patient symptom burden as a priority

  • In the expected future treatment landscape, optimised markers of prognosis, response, and quality of life will become increasingly important

 

Consultant Hepatologist and Honorary Senior Lecturer at the John Radcliffe Hospital and University of Oxford. Clinical Lead for autoimmune and cholestatic liver disease in Oxford. National Committee Chair for UK-IgG4, Steering Committee for British Association for the Study of the Liver Immune-Mediated Liver Disease Special Interest Group and UK-PSC, and Scientific Committee for UK-AIH. Medical Advisory Board for the PBC Foundation and Scientific Advisory Board for PSC Support. Translational funding from the Welcome Trust, NIHR Academy of Medical Sciences, NIHR BRC Oxford, and Oxford Charitable Fund.

Dr Emma Culver has received financial support/sponsorship for research support, consultation, or speaker fees from the following companies:

Advisory Boards for Horizon Therapeutics, Zenus Biopharma, Sanofi, Moderna and Falk Pharma

Presenter fees for Falk Pharma, Horizon and Intercept.

Prof. Gideon Hirschfield has received financial support/sponsorship for research support, consultation, or speaker fees from the following companies:

Prof. Hirschfield received financial support/sponsorship from Advanz, Cymabay, Escient, GSK, Intercept, Ipsen, Miram and Pliant

Kath qualified as a nurse at Ormskirk Hospital, West Lancashire.  She gained experience in major abdominal and vascular theatres at both Ninewells Hospital in Dundee and at Heartlands Hospital in Birmingham.  In 2000 she joined the team at the Royal Victoria Infirmary in Newcastle upon Tyne as an endoscopy nurse before taking up a dual Nurse Specialist/research role with the Upper GI Regional Team at the Northern Oesophageal Gastric Cancer Unit. 

 

Since 2013 Kath has worked in the Hepatology Unit at the Freeman hospital, within the Newcastle Hospitals NHS Foundation Trust, where she has developed an interested in PBC. Currently she works in a dual role covering both research and as the first dedicated Autoimmune Liver Nurse Specialist within the trust, where she focused on patients with PBC.  Kath set up a nurse led PBC telephone clinic and helped to manage the PBC ODN.  She is also part of the PBC Connect educational cohort along with 2 consultants and 2 other nurse specialists from Cambridge, London, Birmingham and Oxford, helping to educate around PBC.

 

CEO at PBC Foundation, Chair of Global Liver Institute’s Paediatric and Rare Liver Disease Council and is also Chair of umbrella organisation, Liver Patients International. PBC Foundation is a UK-based international patient support and advocacy non-profit organisation that supports over 20,000 patients in over 80 countries around the world

Mr Robert Mitchell-Thain has received financial support/sponsorship for research support, consultation, or speaker fees from the following companies:

The PBC Foundation has received funding from Advanz, Calliditas, Cara, Cymabay, Escient, GSK, Intercept, Ipsen, Mirum, and Umecrine.

Programme summary
Listen to the podcast now
Other episodes in this series
Primary Biliary Cholangitis Highlights from EASL 2023

Primary Biliary Cholangitis Highlights from EASL 2023

Episode 1: PBC Highlights from EASL

Primary Biliary Cholangitis Highlights from EASL 2023

Primary Biliary Cholangitis Highlights from EASL 2023

Episode 2: PBC Highlights from EASL 2023

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