Primary Biliary Cholangitis Highlights from EASL 2023
Primary Biliary Cholangitis Highlights from EASL 2023
Liver disease experts share their perspectives on key Primary Biliary Cholangitis data from EASL 2023
Liver disease experts share their perspectives on key Primary Biliary Cholangitis data from EASL 2023
Dr Emma Culver, Prof. Gideon Hirschfield, Ms Kath Houghton, Mr Robert Mitchell-Thain
In these two podcasts, medical experts and a patient representative share their perspectives on new Primary Biliary Cholangitis (PBC) data from EASL 2023.
In podcast 1, physicians Dr Emma Culver and Prof. Gideon Hirschfield discuss the evidence of cancer risk associated with PBC, how liver stiffness progression is associated with prognosis; and outcomes and response prediction in second-line therapy.
In podcast 2, CEO of the PBC Foundation, Robert Mitchell-Thain, and autoimmune specialist nurse Kath Houghton explore the impact of PBC symptoms and new instruments for assessing them. They also discuss data highlighting the importance of the current move toward normalisation of liver biomarkers and take a look at some early data on future therapies and therapeutic targets.
Transcripts, with details of the presentations covered, are available for download.
Dr Emma Culver
Hepatologist
John Radcliffe Hospital and University of Oxford
United Kingdom (UK)
Prof. Gideon Hirschfield
Professor of Medicine
Division of Gastroenterology, University of Toronto
Canada
Ms Kath Houghton
Specialist Nurse
Newcastle Hospitals NHS Foundation Trust
United Kingdom (UK)
Mr Robert Mitchell-Thain
Advocacy
PBC Foundation
United Kingdom (UK)
Dr Emma Culver
Hepatologist
John Radcliffe Hospital and University of Oxford
United Kingdom (UK)
Consultant Hepatologist and Honorary Senior Lecturer at the John Radcliffe Hospital and University of Oxford. Clinical Lead for autoimmune and cholestatic liver disease in Oxford. National Committee Chair for UK-IgG4, Steering Committee for British Association for the Study of the Liver Immune-Mediated Liver Disease Special Interest Group and UK-PSC, and Scientific Committee for UK-AIH. Medical Advisory Board for the PBC Foundation and Scientific Advisory Board for PSC Support. Translational funding from the Welcome Trust, NIHR Academy of Medical Sciences, NIHR BRC Oxford, and Oxford Charitable Fund.
Dr Emma Culver has received financial support/sponsorship for research support, consultation, or speaker fees from the following companies:
Advisory Boards for Horizon Therapeutics, Zenus Biopharma, Sanofi, Moderna and Falk Pharma
Presenter fees for Falk Pharma, Horizon and Intercept.
Prof. Gideon Hirschfield
Professor of Medicine
Division of Gastroenterology, University of Toronto
Canada
Prof. Gideon Hirschfield has received financial support/sponsorship for research support, consultation, or speaker fees from the following companies:
Prof. Hirschfield received financial support/sponsorship from Advanz, Cymabay, Escient, GSK, Intercept, Ipsen, Miram and Pliant
Ms Kath Houghton
Specialist Nurse
Newcastle Hospitals NHS Foundation Trust
United Kingdom (UK)
Kath qualified as a nurse at Ormskirk Hospital, West Lancashire. She gained experience in major abdominal and vascular theatres at both Ninewells Hospital in Dundee and at Heartlands Hospital in Birmingham. In 2000 she joined the team at the Royal Victoria Infirmary in Newcastle upon Tyne as an endoscopy nurse before taking up a dual Nurse Specialist/research role with the Upper GI Regional Team at the Northern Oesophageal Gastric Cancer Unit.
Since 2013 Kath has worked in the Hepatology Unit at the Freeman hospital, within the Newcastle Hospitals NHS Foundation Trust, where she has developed an interested in PBC. Currently she works in a dual role covering both research and as the first dedicated Autoimmune Liver Nurse Specialist within the trust, where she focused on patients with PBC. Kath set up a nurse led PBC telephone clinic and helped to manage the PBC ODN. She is also part of the PBC Connect educational cohort along with 2 consultants and 2 other nurse specialists from Cambridge, London, Birmingham and Oxford, helping to educate around PBC.
Mr Robert Mitchell-Thain
Advocacy
PBC Foundation
United Kingdom (UK)
CEO at PBC Foundation, Chair of Global Liver Institute’s Paediatric and Rare Liver Disease Council and is also Chair of umbrella organisation, Liver Patients International. PBC Foundation is a UK-based international patient support and advocacy non-profit organisation that supports over 20,000 patients in over 80 countries around the world
Mr Robert Mitchell-Thain has received financial support/sponsorship for research support, consultation, or speaker fees from the following companies:
The PBC Foundation has received funding from Advanz, Calliditas, Cara, Cymabay, Escient, GSK, Intercept, Ipsen, Mirum, and Umecrine.
PBC Highlights from EASL: Episode 1
Podcast |
30 min
|
Jun 2023
This programme was made for you: your opinion matters
Share your feedback in just 4 clicks and help us to continue to create the content you need.
I agree that this educational programme:
Was valuable to me:
1/4
Has improved my knowledge of this topic:
2/4
Is likely to change my clinical practice:
3/4
Was balanced and unbiased:
4/4
download resources
This programme was made for you: your opinion matters
Share your feedback in just 4 clicks and help us to continue to create the content you need.
I agree that this educational programme:
Was valuable to me:
1/4
Has improved my knowledge of this topic:
2/4
Is likely to change my clinical practice:
3/4
Was balanced and unbiased:
4/4
PBC Highlights from EASL 2023: Episode 2
Podcast |
22 min
|
Jun 2023
This programme was made for you: your opinion matters
Share your feedback in just 4 clicks and help us to continue to create the content you need.
I agree that this educational programme:
Was valuable to me:
1/4
Has improved my knowledge of this topic:
2/4
Is likely to change my clinical practice:
3/4
Was balanced and unbiased:
4/4
download resources
This programme was made for you: your opinion matters
Share your feedback in just 4 clicks and help us to continue to create the content you need.
I agree that this educational programme:
Was valuable to me:
1/4
Has improved my knowledge of this topic:
2/4
Is likely to change my clinical practice:
3/4
Was balanced and unbiased:
4/4
Clinical Takeaways
-
When treating people living with PBC, the goal is to aim for normal liver blood tests and normal quality of life
-
Emerging therapies are hoped to both significantly address biochemical and symptom control in PBC
-
Pruritus and fatigue can be devastating, and upcoming trials importantly are addressing alleviation of patient symptom burden as a priority
-
In the expected future treatment landscape, optimised markers of prognosis, response, and quality of life will become increasingly important
This educational programme is supported by an Independent Medical Education Grant from Ipsen