Experts Prof. de Mestier, Prof. Vandamme, and Dr Durand share their insights on the latest data presented at the ENETS 2026 conference and discuss how these may impact clinical practice.
Watch the video update to hear the Experts discuss the breakthrough results presented from the COMPETE study with PRRT in pancreatic NETS before targeted therapy, as well as opinions on strategies for re-challenge with PRRT in NET patients.
They also discuss the positive data from the DAREONTM-7 trial of obrixtamig, a DLL3-targeted bi-specific T cell engager, as 1st line therapy for advanced NEC, and the role of surgery in stage 1–3 disease. In addition, they discuss the interesting combination treatment of cabozantinib and temozolomide for NETs.
Clinical takeaways
- A COMPETE trial subgroup analysis demonstrated significant benefit of PRRT over everolimus, supporting integration of PRRT before targeted therapy in the treatment sequence
- Re-challenging PRRT in NET patients showed promising efficacy, although there is a need for careful hematological monitoring
- Obrixtamig, a DLL3 bi-specific T cell engager, achieved disease control as 1st line therapy for advanced NECs with durable responses, suggesting an encouraging new therapeutic approach
- Surgical resection of stage 1−3 NECs is associated with improved survival compared to chemotherapy; most relapses occur within 3 years with no relapses after 4.5 years, informing follow-up duration post-resection



5 MIN
Mar 2026
Downloadable
