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In this NTRK CONNECT podcast Prof Frédérique Penault-Llorca and Prof Andrea Sartore-Bianchi discuss the detection and management of TRK fusion-positive GI cancers.

 

This programme is supported by an Independent Educational Grant from Bayer

In the GI episode, Prof Frédérique Penault-Llorca and Prof Andrea Sartore-Bianchi provide a summary and share their personal experiences about the diagnosis and treatment of TRK fusion-positive GI cancer.

Prof Sartore-Bianchi provides an overview of NTRK genes and the biology of NTRK fusions, including their role as a driver of oncogenesis. He then provides a concise summary of the approved TRK inhibitor therapies, larotrectinib and entrectinib, emphasising the expanding dataset showing high response rates and durable responses seen in patients with GI cancers.

Prof Penault-Llorca outlines the challenges pathologists face detecting the extremely rare NTRK fusions in GI cancers, providing a summary of the range of tools available to detect them and offering her perspectives on an enrichment strategy for GI cancers, especially colorectal cancer.

They conclude by emphasising the importance of not missing any patients, through applying enrichment strategies that can enhance the likelihood of finding NTRK fusions. In doing so, more patients will be able to benefit from the proven efficacy of TRK inhibitor therapy.

 

Podcast Transcript

Frédérique Penault-Llorca

Today, with Andrea we are going to go through the diagnosis and treatment of NTRK fusion-positive GI cancers. Andrea, what are the NTRK genes, and what about the NTRK fusion; why are they so interesting to look at in GI cancers?

Andrea Sartore-Bianchi

Yes, thank you Frédérique, and indeed we know the gene fusions can be a driver of oncogenesis, but it is now when we are seeing very important advances in clinical sequencing technologies that we are aware of new…

Frédérique PENAULT-LLORCA, MD, PhD, graduated as a medical specialist in pathology in 1993 and in oncology in 1995. Also, in 1995, she received a PhD from the Université d’Aix-Marseille II in cellular biology and microbiology, on the topic of HER2. Professor PENAULT-LLORCA is currently professor of Pathology at the University of Clermont-Ferrand, CEO of the Comprehensive Regional Cancer Institute Centre Jean PERRIN, deputy director of the research team INSERM 1240 IMoST, and head of the Molecular Biology Plateform at Centre Jean Perrin, Clermont-Ferrand, France, and Vice-President of UNICANCER GROUP. She chairs the Immuno- Oncology group at UNICANCER R&D. She is a member of several pathology and oncology societies (ESMO, ASCO, ECP, AIP, SFP. Her main areas of interest as a pathology being female cancers. Professor PENAULT-LLORCA has conducted various biomarkers-based research studies in breast, ovarian, colorectal, gastric, and lung cancer in relation to response to targeted therapies and immunotherapies. She also acts as a coordinating pathologist for various oncology trials. Professor PENAULT-LLORCA has written more than 440 peer-reviewed publications and several books on female cancers and biomarker testing methods and issues.

Prof. Frédérique Penault-Llorca has received financial support/sponsorship for research support, consultation, or speaker fees from the following companies:

AbbVie, AstraZeneca, Bayer, BMS, Daiichi Sankyo, Genomic Health, Gilead, GSK, Lilly, Menarini /Stemline, MERCK, MSD, Myriad, NanoString Technologies, Novartis, Pfizer, Pierre-Fabre, Roche, Seagen, Servier, Tesaro; Institutional research grants from  AbbVie, Agendia, AstraZeneca, Bayer, BMS, Genomic Health, MSD, Myriad, NanoString Technologies, Roche; Congress invitations from AbbVie, AstraZeneca, BMS, MSD, Novartis, Pfizer, Roche 

Andrea Sartore-Bianchi is the Director of the Division of Clinical Research and Innovation at Grande Ospedale Metropolitano Niguarda in Milano, Italy, and Associate Professor of Oncology at the University of Milano. He received his MD and postgraduate degree in Oncology at the University of Pavia, Italy, and subsequently conducted preclinical research at Brown University, Providence, RI, USA.

 

His main clinical and research interests include precision oncology and the treatment of gastrointestinal cancers, particularly colorectal carcinomas, focusing on biomarkers of sensitivity/resistance to targeted therapies. He is principal and co-investigator in Phase I-III clinical trials for solid tumours and carried out initial studies paving the way for the use of RAS and Her2 as tumor tissue/ctDNA biomarkers in colorectal cancer. He has published 200 peer-reviewed articles in various medical journals with a H-index of 62 (Scopus).

Prof. Andrea Sartore-Bianchi has received financial support/sponsorship for research support, consultation, or speaker fees from the following companies:

Amgen, Bayer, Sanofi and Servier Pharmaceuticals. 

Listen and follow our podcasts on:

Bayer

In this NTRK CONNECT podcast Prof Frédérique Penault-Llorca and Prof Andrea Sartore-Bianchi discuss the detection and management of TRK fusion-positive GI cancers.

 

This programme is supported by an Independent Educational Grant from Bayer

Frédérique PENAULT-LLORCA, MD, PhD, graduated as a medical specialist in pathology in 1993 and in oncology in 1995. Also, in 1995, she received a PhD from the Université d’Aix-Marseille II in cellular biology and microbiology, on the topic of HER2. Professor PENAULT-LLORCA is currently professor of Pathology at the University of Clermont-Ferrand, CEO of the Comprehensive Regional Cancer Institute Centre Jean PERRIN, deputy director of the research team INSERM 1240 IMoST, and head of the Molecular Biology Plateform at Centre Jean Perrin, Clermont-Ferrand, France, and Vice-President of UNICANCER GROUP. She chairs the Immuno- Oncology group at UNICANCER R&D. She is a member of several pathology and oncology societies (ESMO, ASCO, ECP, AIP, SFP. Her main areas of interest as a pathology being female cancers. Professor PENAULT-LLORCA has conducted various biomarkers-based research studies in breast, ovarian, colorectal, gastric, and lung cancer in relation to response to targeted therapies and immunotherapies. She also acts as a coordinating pathologist for various oncology trials. Professor PENAULT-LLORCA has written more than 440 peer-reviewed publications and several books on female cancers and biomarker testing methods and issues.

Prof. Frédérique Penault-Llorca has received financial support/sponsorship for research support, consultation, or speaker fees from the following companies:

AbbVie, AstraZeneca, Bayer, BMS, Daiichi Sankyo, Genomic Health, Gilead, GSK, Lilly, Menarini /Stemline, MERCK, MSD, Myriad, NanoString Technologies, Novartis, Pfizer, Pierre-Fabre, Roche, Seagen, Servier, Tesaro; Institutional research grants from  AbbVie, Agendia, AstraZeneca, Bayer, BMS, Genomic Health, MSD, Myriad, NanoString Technologies, Roche; Congress invitations from AbbVie, AstraZeneca, BMS, MSD, Novartis, Pfizer, Roche 

Andrea Sartore-Bianchi is the Director of the Division of Clinical Research and Innovation at Grande Ospedale Metropolitano Niguarda in Milano, Italy, and Associate Professor of Oncology at the University of Milano. He received his MD and postgraduate degree in Oncology at the University of Pavia, Italy, and subsequently conducted preclinical research at Brown University, Providence, RI, USA.

 

His main clinical and research interests include precision oncology and the treatment of gastrointestinal cancers, particularly colorectal carcinomas, focusing on biomarkers of sensitivity/resistance to targeted therapies. He is principal and co-investigator in Phase I-III clinical trials for solid tumours and carried out initial studies paving the way for the use of RAS and Her2 as tumor tissue/ctDNA biomarkers in colorectal cancer. He has published 200 peer-reviewed articles in various medical journals with a H-index of 62 (Scopus).

Prof. Andrea Sartore-Bianchi has received financial support/sponsorship for research support, consultation, or speaker fees from the following companies:

Amgen, Bayer, Sanofi and Servier Pharmaceuticals. 

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PRECISION ONCOLOGY CONNECT

PRECISION ONCOLOGY CONNECT is an initiative of COR2ED, supported by Independent Educational Grants from AstraZeneca, Amoy Diagnostics, Bayer, Pierre Fabre Laboratories and Thermo Fisher Scientific.

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Programme summary
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Listen to the podcast now
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This educational programme is supported by an Independent Educational Grant from Bayer
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This educational programme is supported by an Independent Educational Grant from Bayer
I agree that this educational programme:

Was valuable to me

1/4
Brought to you by
PRECISION ONCOLOGY CONNECT

PRECISION ONCOLOGY CONNECT is an initiative of COR2ED, supported by Independent Educational Grants from AstraZeneca, Amoy Diagnostics, Bayer, Pierre Fabre Laboratories and Thermo Fisher Scientific.

Meet the experts Independent IME approved

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