Dr. Jonathan C. Trent earned his MD and PhD in cancer biology from The University of Texas Health
Science Center where he also completed a residency in internal medicine. He then completed a
fellowship in medical oncology at The University of Texas M. D. Anderson Cancer Center while serving
as chief fellow. Prior to joining the University of Miami, Sylvester Comprehensive Cancer Center, he
held an appointment as associate professor of medicine in the Department of Sarcoma Medical Oncology,
Division of Cancer Medicine at the University of Texas M. D. Anderson Cancer Center in Houston. Dr.
Trent is currently the Associate Director for Clinical Research, the Director of the Bone and Soft-tissue
Sarcoma Group and Medical Director of the Precision Medicine Initiative at the Sylvester Comprehensive
Cancer Center.
Dr. Trent’s interests are in the clinical and translational research of sarcomas, direct care of sarcoma
patients, and education about sarcoma. As Associate Director for Clinical Research, his goal is to help
Sylvester Faculty develop clinical trials that provide clinically effective and scientifically exciting therapy
to cancer patients of South Florida and beyond.
The major focus of his clinical, educational and research efforts are with gastrointestinal stromal tumor
(GIST), chondrosarcoma, and other sarcomas. The major efforts of Dr. Trent’s research focus on
understanding the mechanisms of action and resistance of imatinib in GIST and other sarcomas while
striving toward improved therapeutic options. His work involves the use of novel
preoperative/postoperative clinical trials, prospectively acquired tumor tissue, cell lines, archival tissue, as
well as collaborations with disciplines such as the genomics facility, surgical oncology, pathology,
radiology and interventional radiology.
Conference Update 
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