In this 2-part animated video series, medical oncologists Prof. Eileen O’Reilly and Prof. Efrat Dotan provide an overview of the different treatment options for metastatic pancreatic ductal adenocarcinoma (PDAC). 

In this 2-part animated video series, medical oncologists Prof. Eileen O’Reilly and Prof. Efrat Dotan provide an overview of the different treatment options for metastatic pancreatic ductal adenocarcinoma (PDAC). 

In video 1, you'll hear about 1st line chemotherapy options, drawing on data from key clinical trials, as well as considering the role of targeted therapy, where appropriate.

 

Video 2 addresses 2nd line chemotherapy options and how earlier treatments have an impact on treatment sequence.  

 

You can also download the accompanying slides for each video for more details. Coming soon: a short accredited assessment to test your knowledge.

 

Clinical takeaways

  • Pancreatic ductal adenocarcinoma (PDAC) is usually diagnosed at an advanced, incurable stage due to non-specific symptoms and has an extremely poor prognosis 

  • Systemic chemotherapy is the standard treatment for metastatic PDAC, but molecularly targeted treatments and immunotherapies may have a role for specific patients 

  • Treatment selection depends on several factors, including patients' performance status and co-morbidities. These should be considered alongside the efficacy and safety profiles of the different chemotherapy regimens

  • Treatment strategies can be implemented to manage toxicities associated with the different chemotherapy regimens to enable a patient to stay on treatment for optimal efficacy 

  • Be able to differentiate the efficacy and safety profiles of chemotherapies for metastatic PDAC and understand how mode of delivery plays a role in this 
  • Be able to recognise the cause of toxicities and have an awareness of strategies that can be used to improve tolerability and manage side effects whilst maintaining optimal efficacy 

Eileen M. O’Reilly holds the Winthrop Rockefeller Endowed Chair in Medical Oncology at Memorial Sloan Kettering (MSK). She serves as the Section Head for Hepatopancreaticobiliary/ Neuroendocrine Cancers, Gastrointestinal Oncology Service, Co-Director for Medical Initiatives at the David M. Rubenstein Center for Pancreatic Cancer and is an Attending Physician and Member at MSK and Professor of Medicine at Weill Cornell Medical College.

 

Dr. O’Reilly received her medical degree at Trinity College in Ireland. She completed her postgraduate training in Ireland and subsequent Hematology/Oncology Fellowship training at MSK. Dr. O’Reilly is a clinical scientist whose research focus involves integration of molecular and genetic-based therapies for pancreas cancer along with development of adjuvant and neoadjuvant treatments and identification of biomarkers for therapy selection. Dr. O’Reilly teaches and mentors junior faculty, oncology fellows, residents and medical/other students and has numerous teaching and other awards. Dr. O’Reilly is the Principal Investigator of multiple phase I, II, III trials in pancreas cancer and has authored/co-authored ~425 articles, editorials, and book chapters and has a H-index of 100. She serves as an Associate Editor for the Journal of Clinical Oncology and Senior Editor for several other journals and has served on multiple grant review panels including, for the American Society of Clinical Oncology (ASCO), American Association of Cancer Research (AACR), NIH, DOD, and various international entities. She is PI of the MSK Pancreas Specialized Program in Oncology Research Excellence (SPORE), an NCI funded team science grant. Dr. O’Reilly is the recipient of numerous awards including the Burkitt Medal (TCD) in 2022, and Giants of Cancer Care GI Oncology, 2023.

 

Dr. O’Reilly’s other responsibilities include Chair of the Human Research Protection Program and Institutional Review & Privacy Board (IRB). Nationally, Dr. O’Reilly is Co-Chair of the NCI Alliance Co-Operative Group Gastrointestinal Cancers Committee and serves on the NCI Gastrointestinal Cancers Steering Committee (GISC) and serves in leadership roles in several advocacy organizations including the National Pancreas Foundation, Hirshberg Foundation and Pancreas Cancer Action Network.

Prof. Eileen O'Reilly has received financial support/sponsorship for research support, consultation, or speaker fees from the following companies:

Research Funding to institution: Genentech/Roche, BioNTech, AstraZeneca, Arcus, Elicio, Parker Institute, NIH/NCI, Digestive Care, Break Through Cancer, Agenus, Amgen, Revolution Medicines

 

Consulting/DSMB (mostly uncompensated): Arcus, AstraZeneca, Ability Pharma, Alligator BioSciences, Agenus, BioNTech, Ipsen, Ikena, Merck, Moma Therapeutics, Novartis, Leap Therapeutics, Astellas, BMS, Revolution Medicines, Regeneron, Tango.

 

Travel: BioNTech

 

 

Prof. Efrat Dotan is the executive medical director for Penn Medicine Ann B. Barshinger Cancer Institute in Lancaster, Pennsylvania. She graduated from the Technion Institute of Technology Medical School in Israel and moved to the US to pursue her specialized training. She completed her residency at Lenox Hill Hospital in New York, and her hematology/oncology fellowship at Fox Chase Cancer Center. Prof. Dotan specializes in the management of patients with gastrointestinal malignancies, specifically pancreatic cancer. Her research interest is in development of new treatment options for patients with gastrointestinal cancers. She is the PI for multiple clinical trials in this arena. Prof. Dotan is a member of the Gastrointestinal Malignancies Committee of the Eastern Cooperative Oncology Group (ECOG), serves as the PI for multiple studies and is co-chair of the NCI pancreatic task force. Dr Dotan’s other interest is in the management of older patients with cancer, developing treatment strategies and tools to improve the care of this patient population. She has led multiple research projects evaluating the care of older patients with gastrointestinal malignancies. She is a senior member of the Cancer and Aging Research Group, the chair of the Older Adult Oncology Guidelines for NCCN and the chair of the geriatric oncology working group for ECOG.

Prof. Efrat Dotan has received financial support/sponsorship for research support, consultation, or speaker fees from the following companies:

Agenus, Amgen, Ipsen, Merck, MERUS, Olympus, Pfizer, TME Biopharmaceuticals

In video 1, you'll hear about 1st line chemotherapy options, drawing on data from key clinical trials, as well as considering the role of targeted therapy, where appropriate.

 

Video 2 addresses 2nd line chemotherapy options and how earlier treatments have an impact on treatment sequence.  

 

You can also download the accompanying slides for each video for more details. Coming soon: a short accredited assessment to test your knowledge.

 

Clinical takeaways

  • Pancreatic ductal adenocarcinoma (PDAC) is usually diagnosed at an advanced, incurable stage due to non-specific symptoms and has an extremely poor prognosis 

  • Systemic chemotherapy is the standard treatment for metastatic PDAC, but molecularly targeted treatments and immunotherapies may have a role for specific patients 

  • Treatment selection depends on several factors, including patients' performance status and co-morbidities. These should be considered alongside the efficacy and safety profiles of the different chemotherapy regimens

  • Treatment strategies can be implemented to manage toxicities associated with the different chemotherapy regimens to enable a patient to stay on treatment for optimal efficacy 

  • Be able to differentiate the efficacy and safety profiles of chemotherapies for metastatic PDAC and understand how mode of delivery plays a role in this 
  • Be able to recognise the cause of toxicities and have an awareness of strategies that can be used to improve tolerability and manage side effects whilst maintaining optimal efficacy 

Eileen M. O’Reilly holds the Winthrop Rockefeller Endowed Chair in Medical Oncology at Memorial Sloan Kettering (MSK). She serves as the Section Head for Hepatopancreaticobiliary/ Neuroendocrine Cancers, Gastrointestinal Oncology Service, Co-Director for Medical Initiatives at the David M. Rubenstein Center for Pancreatic Cancer and is an Attending Physician and Member at MSK and Professor of Medicine at Weill Cornell Medical College.

 

Dr. O’Reilly received her medical degree at Trinity College in Ireland. She completed her postgraduate training in Ireland and subsequent Hematology/Oncology Fellowship training at MSK. Dr. O’Reilly is a clinical scientist whose research focus involves integration of molecular and genetic-based therapies for pancreas cancer along with development of adjuvant and neoadjuvant treatments and identification of biomarkers for therapy selection. Dr. O’Reilly teaches and mentors junior faculty, oncology fellows, residents and medical/other students and has numerous teaching and other awards. Dr. O’Reilly is the Principal Investigator of multiple phase I, II, III trials in pancreas cancer and has authored/co-authored ~425 articles, editorials, and book chapters and has a H-index of 100. She serves as an Associate Editor for the Journal of Clinical Oncology and Senior Editor for several other journals and has served on multiple grant review panels including, for the American Society of Clinical Oncology (ASCO), American Association of Cancer Research (AACR), NIH, DOD, and various international entities. She is PI of the MSK Pancreas Specialized Program in Oncology Research Excellence (SPORE), an NCI funded team science grant. Dr. O’Reilly is the recipient of numerous awards including the Burkitt Medal (TCD) in 2022, and Giants of Cancer Care GI Oncology, 2023.

 

Dr. O’Reilly’s other responsibilities include Chair of the Human Research Protection Program and Institutional Review & Privacy Board (IRB). Nationally, Dr. O’Reilly is Co-Chair of the NCI Alliance Co-Operative Group Gastrointestinal Cancers Committee and serves on the NCI Gastrointestinal Cancers Steering Committee (GISC) and serves in leadership roles in several advocacy organizations including the National Pancreas Foundation, Hirshberg Foundation and Pancreas Cancer Action Network.

Prof. Eileen O'Reilly has received financial support/sponsorship for research support, consultation, or speaker fees from the following companies:

Research Funding to institution: Genentech/Roche, BioNTech, AstraZeneca, Arcus, Elicio, Parker Institute, NIH/NCI, Digestive Care, Break Through Cancer, Agenus, Amgen, Revolution Medicines

 

Consulting/DSMB (mostly uncompensated): Arcus, AstraZeneca, Ability Pharma, Alligator BioSciences, Agenus, BioNTech, Ipsen, Ikena, Merck, Moma Therapeutics, Novartis, Leap Therapeutics, Astellas, BMS, Revolution Medicines, Regeneron, Tango.

 

Travel: BioNTech

 

 

Prof. Efrat Dotan is the executive medical director for Penn Medicine Ann B. Barshinger Cancer Institute in Lancaster, Pennsylvania. She graduated from the Technion Institute of Technology Medical School in Israel and moved to the US to pursue her specialized training. She completed her residency at Lenox Hill Hospital in New York, and her hematology/oncology fellowship at Fox Chase Cancer Center. Prof. Dotan specializes in the management of patients with gastrointestinal malignancies, specifically pancreatic cancer. Her research interest is in development of new treatment options for patients with gastrointestinal cancers. She is the PI for multiple clinical trials in this arena. Prof. Dotan is a member of the Gastrointestinal Malignancies Committee of the Eastern Cooperative Oncology Group (ECOG), serves as the PI for multiple studies and is co-chair of the NCI pancreatic task force. Dr Dotan’s other interest is in the management of older patients with cancer, developing treatment strategies and tools to improve the care of this patient population. She has led multiple research projects evaluating the care of older patients with gastrointestinal malignancies. She is a senior member of the Cancer and Aging Research Group, the chair of the Older Adult Oncology Guidelines for NCCN and the chair of the geriatric oncology working group for ECOG.

Prof. Efrat Dotan has received financial support/sponsorship for research support, consultation, or speaker fees from the following companies:

Agenus, Amgen, Ipsen, Merck, MERUS, Olympus, Pfizer, TME Biopharmaceuticals

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Programme summary
Watch the video now
Share this programme
This educational programme is supported by an Independent Educational Grant from Ipsen USA.
Supporter Acknowledgement
This educational programme is supported by an Independent Educational Grant from Ipsen USA.
Endorsement
I agree that this educational programme:

Was valuable to me

1/4
Brought to you by
GI CONNECT

GI CONNECT is an initiative of COR2ED, supported by Independent Educational Grants from Bayer, Ipsen, BeiGene Europe and Pierre Fabre Laboratories.  

Meet the experts
Brought to you by
GI NURSES CONNECT

GI NURSES CONNECT is an initiative of COR2ED, supported by Independent Educational Grants from Bayer and Eisai Europe Limited.

Meet the experts Independent IME approved

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