In this short, chaptered video programme, Dr Chad Deal, Head of the Center for Osteoporosis and Metabolic Bone Disease at the Cleveland Clinic, shares practical insights to help clinicians identify patients with hypophosphatasia (HPP).

 

Despite being a lifelong metabolic condition, HPP is often under-recognised, especially in adults. Dr Deal discusses the importance of distinguishing HPP from other musculoskeletal and rheumatic diseases that HPP commonly disguises itself as, including osteoporosis, fibromyalgia, pseudogout, and arthritis-like conditions1-5. He also explains how understanding the clinical presentation, recognising HPP signs and symptoms, and taking a detailed patient and family history can support timely diagnosis and appropriate care.

 

Watch the full video or browse by chapter using the tabs below.

In this short, chaptered video programme, Dr Chad Deal, Head of the Center for Osteoporosis and Metabolic Bone Disease at the Cleveland Clinic, shares practical insights to help clinicians identify, patients with hypophosphatasia (HPP).

 

Despite being a lifelong metabolic condition, HPP is often under-recognised, especially in adults. Dr Deal discusses the importance of distinguishing HPP from other musculoskeletal and rheumatic diseases that HPP commonly disguises itself as, including osteoporosis, fibromyalgia, pseudogout, and arthritis-like conditions1-5. He also explains how understanding the clinical presentation, recognising HPP signs and symptoms, and taking a detailed patient and family history can support timely diagnosis and appropriate care.

 

Watch the full video or browse by chapter using the tabs below.

In this short, chaptered video programme, Dr Chad Deal, Head of the Center for Osteoporosis and Metabolic Bone Disease at the Cleveland Clinic, shares practical insights to help clinicians identify, patients with hypophosphatasia (HPP).

 

Despite being a lifelong metabolic condition, HPP is often under-recognised, especially in adults. Dr Deal discusses the importance of distinguishing HPP from other musculoskeletal and rheumatic diseases that HPP commonly disguises itself as, including osteoporosis, fibromyalgia, pseudogout, and arthritis-like conditions1-5. He also explains how understanding the clinical presentation, recognising HPP signs and symptoms, and taking a detailed patient and family history can support timely diagnosis and appropriate care.

 

Watch the full video or browse by chapter using the tabs below.

In this short, chaptered video programme, Dr Chad Deal, Head of the Center for Osteoporosis and Metabolic Bone Disease at the Cleveland Clinic, shares practical insights to help clinicians identify, patients with hypophosphatasia (HPP).

 

Despite being a lifelong metabolic condition, HPP is often under-recognised, especially in adults. Dr Deal discusses the importance of distinguishing HPP from other musculoskeletal and rheumatic diseases that HPP commonly disguises itself as, including osteoporosis, fibromyalgia, pseudogout, and arthritis-like conditions1-5. He also explains how understanding the clinical presentation, recognising HPP signs and symptoms, and taking a detailed patient and family history can support timely diagnosis and appropriate care.

 

Watch the full video or browse by chapter using the tabs below.

In this short, chaptered video programme, Dr Chad Deal, Head of the Center for Osteoporosis and Metabolic Bone Disease at the Cleveland Clinic, shares practical insights to help clinicians identify, patients with hypophosphatasia (HPP).

 

Despite being a lifelong metabolic condition, HPP is often under-recognised, especially in adults. Dr Deal discusses the importance of distinguishing HPP from other musculoskeletal and rheumatic diseases that HPP commonly disguises itself as, including osteoporosis, fibromyalgia, pseudogout, and arthritis-like conditions1-5. He also explains how understanding the clinical presentation, recognising HPP signs and symptoms, and taking a detailed patient and family history can support timely diagnosis and appropriate care.

 

Watch the full video or browse by chapter using the tabs below.

Dr Chad Deal shares his insights on:

  • Recognising presentations of HPP, including key symptoms and common misdiagnoses (Chapter 1)
  • HPP diagnosis and earlier recognition of HPP signs and symptoms and the impact of deficient ALP  (Chapter 2)
  • The role of family history in identifying other affected individuals with HPP (Chapter 3)
  • The evolution of our understanding that led us to rethink HPP (Chapter 4)

 

Next:

  • View 5 fact cards here to reveal key statistics and clinical insights on the diagnosis and disease burden of (HPP) in children and adults. Will they make you rethink HPP diagnosis and disease burden?
  • Watch a short animated video on rethinking HPP disease burden and the systemic impacts of deficient alkaline phosphate activity

 

1.Bangura A, et al. Cureus. 2020;12(6):e8594; 2. Braunstein NA. Bone Rep. 2015;4:1–4; 3. Nunes ME. Hypophosphatasia. 2007 Nov 20 [Updated 2023 Mar 30]. In Adam MP, et al., editors. GeneReviews® [Internet]. Seattle (WA): University of Washington, Seattle; 1993–2024. 4. Rush et al Osteoporosis International (2024) 35:1–10 5. Khan et al Osteoporosis International (2023) 35:431–438

Dr Chad Deal is the head of the Center for Osteoporosis and Metabolic Bone Disease at The Cleveland Clinic in Ohio.

 

A practicing rheumatologist at The Cleveland Clinic, he is a board certified in rheumatology and internal medicine.

 

Dr Deal did his undergraduate work at Washington University in St. Louis. He attended medical school at the University of Arkansas, was Alpha Omega Alpha, and graduated in 1977. His internship and residency were at Boston City Hospital in Massachusetts. He completed a fellowship in arthritis and connective tissue diseases at Boston University School of Medicine in 1982.

 

Dr Deal has been in Cleveland since 1984. He was an associate professor of medicine at the Case Western Reserve University School of Medicine until 1999 when he left to join The Cleveland Clinic.

 

He has been an active investigator in multiple clinical trials relating to arthritis and osteoporosis and is author of more than 70 publications. Dr Deal is a Master of the American College of Rheumatology and is an Associate Editor for Arthritis and Rheumatology.

Dr Chad Deal has received financial support/sponsorship for research support, consultation, or speaker fees from the following companies:

Amgen, Alexion Pharmaceuticals and Radius Health

Dr Chad Deal shares his insights on:

  • Recognising presentations of HPP, including key symptoms and common misdiagnoses (Chapter 1)
  • HPP diagnosis and earlier recognition of HPP signs and symptoms and the impact of deficient ALP  (Chapter 2)
  • The role of family history in identifying other affected individuals with HPP (Chapter 3)
  • The evolution of our understanding that led us to rethink HPP (Chapter 4)

Next:

  • View 5 fact cards here to reveal key statistics and clinical insights on the diagnosis and disease burden of (HPP) in children and adults. Will they make you rethink HPP diagnosis and disease burden?
  • Watch a short animated video on rethinking HPP disease burden and the systemic impacts of deficient alkaline phosphate activity

 

1.Bangura A, et al. Cureus. 2020;12(6):e8594; 2. Braunstein NA. Bone Rep. 2015;4:1–4; 3. Nunes ME. Hypophosphatasia. 2007 Nov 20 [Updated 2023 Mar 30]. In Adam MP, et al., editors. GeneReviews® [Internet]. Seattle (WA): University of Washington, Seattle; 1993–2024. 4. Rush et al Osteoporosis International (2024) 35:1–10 5. Khan et al Osteoporosis International (2023) 35:431–438

Dr Chad Deal is the head of the Center for Osteoporosis and Metabolic Bone Disease at The Cleveland Clinic in Ohio.

 

A practicing rheumatologist at The Cleveland Clinic, he is a board certified in rheumatology and internal medicine.

 

Dr Deal did his undergraduate work at Washington University in St. Louis. He attended medical school at the University of Arkansas, was Alpha Omega Alpha, and graduated in 1977. His internship and residency were at Boston City Hospital in Massachusetts. He completed a fellowship in arthritis and connective tissue diseases at Boston University School of Medicine in 1982.

 

Dr Deal has been in Cleveland since 1984. He was an associate professor of medicine at the Case Western Reserve University School of Medicine until 1999 when he left to join The Cleveland Clinic.

 

He has been an active investigator in multiple clinical trials relating to arthritis and osteoporosis and is author of more than 70 publications. Dr Deal is a Master of the American College of Rheumatology and is an Associate Editor for Arthritis and Rheumatology.

Dr Chad Deal has received financial support/sponsorship for research support, consultation, or speaker fees from the following companies:

Amgen, Alexion Pharmaceuticals and Radius Health

Dr Chad Deal shares his insights on:

  • Recognising presentations of HPP, including key symptoms and common misdiagnoses (Chapter 1)
  • HPP diagnosis and earlier recognition of HPP signs and symptoms and the impact of deficient ALP  (Chapter 2)
  • The role of family history in identifying other affected individuals with HPP (Chapter 3)
  • The evolution of our understanding that led us to rethink HPP (Chapter 4)

Next:

  • View 5 fact cards here to reveal key statistics and clinical insights on the diagnosis and disease burden of (HPP) in children and adults. Will they make you rethink HPP diagnosis and disease burden?
  • Watch a short animated video on rethinking HPP disease burden and the systemic impacts of deficient alkaline phosphate activity

 

1.Bangura A, et al. Cureus. 2020;12(6):e8594; 2. Braunstein NA. Bone Rep. 2015;4:1–4; 3. Nunes ME. Hypophosphatasia. 2007 Nov 20 [Updated 2023 Mar 30]. In Adam MP, et al., editors. GeneReviews® [Internet]. Seattle (WA): University of Washington, Seattle; 1993–2024. 4. Rush et al Osteoporosis International (2024) 35:1–10 5. Khan et al Osteoporosis International (2023) 35:431–438

Dr Chad Deal is the head of the Center for Osteoporosis and Metabolic Bone Disease at The Cleveland Clinic in Ohio.

 

A practicing rheumatologist at The Cleveland Clinic, he is a board certified in rheumatology and internal medicine.

 

Dr Deal did his undergraduate work at Washington University in St. Louis. He attended medical school at the University of Arkansas, was Alpha Omega Alpha, and graduated in 1977. His internship and residency were at Boston City Hospital in Massachusetts. He completed a fellowship in arthritis and connective tissue diseases at Boston University School of Medicine in 1982.

 

Dr Deal has been in Cleveland since 1984. He was an associate professor of medicine at the Case Western Reserve University School of Medicine until 1999 when he left to join The Cleveland Clinic.

 

He has been an active investigator in multiple clinical trials relating to arthritis and osteoporosis and is author of more than 70 publications. Dr Deal is a Master of the American College of Rheumatology and is an Associate Editor for Arthritis and Rheumatology.

Dr Chad Deal has received financial support/sponsorship for research support, consultation, or speaker fees from the following companies:

Amgen, Alexion Pharmaceuticals and Radius Health

Dr Chad Deal shares his insights on:

  • Recognising presentations of HPP, including key symptoms and common misdiagnoses (Chapter 1)
  • HPP diagnosis and earlier recognition of HPP signs and symptoms and the impact of deficient ALP  (Chapter 2)
  • The role of family history in identifying other affected individuals with HPP (Chapter 3)
  • The evolution of our understanding that led us to rethink HPP (Chapter 4)

 

Next:

  • View 5 fact cards here to reveal key statistics and clinical insights on the diagnosis and disease burden of (HPP) in children and adults. Will they make you rethink HPP diagnosis and disease burden?
  • Watch a short animated video on rethinking HPP disease burden and the systemic impacts of deficient alkaline phosphate activity

 

1.Bangura A, et al. Cureus. 2020;12(6):e8594; 2. Braunstein NA. Bone Rep. 2015;4:1–4; 3. Nunes ME. Hypophosphatasia. 2007 Nov 20 [Updated 2023 Mar 30]. In Adam MP, et al., editors. GeneReviews® [Internet]. Seattle (WA): University of Washington, Seattle; 1993–2024. 4. Rush et al Osteoporosis International (2024) 35:1–10 5. Khan et al Osteoporosis International (2023) 35:431–438

Dr Chad Deal shares his insights on:

  • Recognising presentations of HPP, including key symptoms and common misdiagnoses (Chapter 1)
  • HPP diagnosis and earlier recognition of HPP signs and symptoms and the impact of deficient ALP  (Chapter 2)
  • The role of family history in identifying other affected individuals with HPP (Chapter 3)
  • The evolution of our understanding that led us to rethink HPP (Chapter 4)

 

Next:

  • View 5 fact cards here to reveal key statistics and clinical insights on the diagnosis and disease burden of (HPP) in children and adults. Will they make you rethink HPP diagnosis and disease burden?
  • Watch a short animated video on rethinking HPP disease burden and the systemic impacts of deficient alkaline phosphate activity

 

1.Bangura A, et al. Cureus. 2020;12(6):e8594; 2. Braunstein NA. Bone Rep. 2015;4:1–4; 3. Nunes ME. Hypophosphatasia. 2007 Nov 20 [Updated 2023 Mar 30]. In Adam MP, et al., editors. GeneReviews® [Internet]. Seattle (WA): University of Washington, Seattle; 1993–2024. 4. Rush et al Osteoporosis International (2024) 35:1–10 5. Khan et al Osteoporosis International (2023) 35:431–438

Dr Chad Deal is the head of the Center for Osteoporosis and Metabolic Bone Disease at The Cleveland Clinic in Ohio.

 

A practicing rheumatologist at The Cleveland Clinic, he is a board certified in rheumatology and internal medicine.

 

Dr Deal did his undergraduate work at Washington University in St. Louis. He attended medical school at the University of Arkansas, was Alpha Omega Alpha, and graduated in 1977. His internship and residency were at Boston City Hospital in Massachusetts. He completed a fellowship in arthritis and connective tissue diseases at Boston University School of Medicine in 1982.

 

Dr Deal has been in Cleveland since 1984. He was an associate professor of medicine at the Case Western Reserve University School of Medicine until 1999 when he left to join The Cleveland Clinic.

 

He has been an active investigator in multiple clinical trials relating to arthritis and osteoporosis and is author of more than 70 publications. Dr Deal is a Master of the American College of Rheumatology and is an Associate Editor for Arthritis and Rheumatology.

Dr Chad Deal has received financial support/sponsorship for research support, consultation, or speaker fees from the following companies:

Amgen, Alexion Pharmaceuticals and Radius Health

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Supporter Acknowledgement

This programme has been initiated and funded by Alexion Pharmaceuticals and is intended for healthcare professionals only. 

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Supporter Acknowledgement

This programme has been initiated and funded by Alexion Pharmaceuticals and is intended for healthcare professionals only. 

Alexion

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Alexion

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Supporter Acknowledgement

This programme has been initiated and funded by Alexion Pharmaceuticals and is intended for healthcare professionals only. 

Alexion

The Alexion logo is a registered trademark of Alexion Pharmaceuticals, Inc.©2024 Alexion Pharmaceuticals, Inc. All rights reserved. GL/UNB-H/0069

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Supporter Acknowledgement

This programme has been initiated and funded by Alexion Pharmaceuticals and is intended for healthcare professionals only. 

Alexion

The Alexion logo is a registered trademark of Alexion Pharmaceuticals, Inc.©2024 Alexion Pharmaceuticals, Inc. All rights reserved. GL/UNB-H/0069

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