Dr Élez reviews data and provides her key clinical takeaways from the following studies:
- BREAKWATER: Analysis of first-line encorafenib + cetuximab + chemotherapy in BRAF V600E-mutant mCRC. Kopetz S, et al. Abstract 16, ASCO GI 2025
- CHECKMATE 8HW: First results of nivolumab plus ipilimumab vs nivolumab monotherapy for MSI-H/dMMR mCRC
Watch the short video and download the accompanying slides to see the key data from these trials.
Clinical takeaways
- BREAKWATER: demonstrated a statistically significant and clinically meaningful benefit in ORR with EC + mFOLFOX6 that was rapid and durable in BRAF V600E-mutant mCRC. The results support EC + mFOLFOX6 as a new first-line SOC for patients with BRAF V600E-mutant CRC
- CHECKMATE 8HW:NIVO + IPI demonstrated statistically significant and clinically meaningful improvement in PFS vs NIVO in patients with MSI-H/dMMR mCRC across all lines of therapy and across prespecified subgroups, including patients who also harboured a BRAF mutation