This month Prof. Sandy Srinivas and Prof. David Pfister provide an interesting overview of Immunotherapy in genitourinary tumors.


Immunotherapy in genitourinary tumors

GU medical oncologists Prof. Sandy Srinivas and Prof. David Pfister give us an insight into the use of immunotherapy in the treatment of genitourinary tumours. Focus is on the toxicity of check-point inhibitors, and handling for best patient care. In this slide and video set they cover which immunotherapies are indicated for use in urothelial carcinoma, prostate cancer, and renal cell cancer.

Considering outcomes and side effects

Discussed are side effects of immunotherapy in renal cell cancer including immune associated side effects, acute phase reactions, and haematotoxicity. Also covered is the FDA approval status of check-point inhibitors including the monoclonal PD-1 and PD-L1 antibodies: durvalumab, pembrolizumab, nivolumab, and atezolizumab. There is an examination of data on overall survival and side effects in a study of nivolumab verses everolimus treatment of renal cell carcinoma (RCC). Additionally, data are presented from two separate studies detailing side effects of nivolumab and atezolizumab in the treatment of urothelial carcinoma. Finally, a discussion on how to spot and manage side effects. Gain clinical insight into immunotherapy use in genitourinary cancer by watching the video and downloading the slides.

Sandy Srinivas specializes in urologic oncology and takes care of patients with prostate, bladder, kidney, testes, penile and adrenal cancers. She has practised in this field now for more than 20 years. She is the clinical research group leader for Urologic Program at Stanford and is a principal investigator on numerous trials in urologic Oncology and is the medical director for the in-patient hematology Oncology unit. She serves as the Vice-chair on the National Comprehensive Cancer Center (NCCN) panel for prostate cancer and has co-authored numerous publications and book chapters. She has received numerous teaching awards and is a nationally recognized expert in the field of Urologic Oncology.

After finishing medical school in November 2004 Dr Pfister started his residency in the Department of Urology at the University of Cologne. For his endoscopic training, he switched to the General Hospital in Weiden (Oberpfalz/Bavaria) between August 2006 and March 2007. After returning to Cologne Dr Pfister heightened my oncologic education under Prof. Heidenreich. The oncologic training consisted of two arms: medical and surgical oncology. In 2009 his education was augmented at the University Hospital of Aachen. In 2010 he passed his urologic board exam. Since 2011 Dr Pfister has been working as a staff urologist with main interests in castration-resistant prostate cancer and testicular cancer. In 2011 he passed the Charles Huggins grant, an educational grant at the Center for Prostate Disease Research in Maryland, USA. In 2012 Dr Pfister received an additional qualification in the systemic treatment of solid tumours and since that time he has organised and led the urological clinical trial centre. In 2012 Dr Pfister qualified as a Professor and became an Associate Professor in November 2012 for medical oncologic treatment in urological tumours. At the end of 2015 he became the Commissionary Leader of the Urologic Department of the University of Aachen. Since 2016 Dr Pfister has become the Deputy Director of the Department of Urology, Uro-oncology and Robot-Assisted Surgery, University Hospital of Cologne. Special interest is castration-resistant, radiation-resistant prostate cancer and testicular cancer.

Prof. David Pfister has received financial support/sponsorship for research support, consultation, or speaker fees from the following companies:

AstraZeneca, Bayer, Merck, MSD, Janssen and Pfizer. 

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This educational programme is supported by an Independent Medical Education Grant from Bayer
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GU CONNECT is an initiative of COR2ED, supported by Independent Educational Medical Grants from Bayer, AstraZeneca and Eisai Europe Limited.

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