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This educational programme is supported by an Independent Medical Education Grant from Viatris

Listen to expert haematologists discuss anticoagulation monitoring in this educational podcast episode. You'll hear Prof. Tsakiris and Assoc. Prof. Nagler talk about:

 

  • Direct oral anticoagulants (DOAC) monitoring scenarios

When DOAC monitoring is necessary for acute situations like bleeding, surgery and thrombolysis, while recognising its limitations

  • Selective anticoagulation monitoring

Differentiating routine monitoring from critical drug level assessments and the impact on clinical decisions and patient care

  • Anti-Xa advantages

The benefits of Anti-Xa assays for anticoagulation monitoring, including potential standardisation and shifting from traditional assays for unfractionated heparin

 

E-learning

After listening to the podcast series, take the e-learning assessment to test your knowledge and earn CME credits.

 

Clinical Takeaways

  • DOAC monitoring is useful in special situations, but need not be done on a routine basis

  • DOAC choice and dosing should be guided by individual clinical characteristics rather than the monitoring results

  • Anti-Xa assays have key advantages in the determination of DOAC drug levels and in the monitoring of unfractionated heparin

  • Patients with vitamin K antagonists should be monitored in designated treatment programmes such as patient self-management

Prof. Dimitrios A. Tsakiris, MD was born in Thessaloniki, Greece and obtained his Diploma of Medicine (1982) at the Medical School, Aristotle University of Thessaloniki, Greece. He started his training in Clinical Haematology at the AHEPA University Hospital in Thessaloniki and completed it at the University Hospital Basel in Basel, Switzerland, where he has been working since 1987. He holds a license for Clinical Haematology and Laboratory Haematology. He spent one year (1996) as a Research Associate in Platelet Research at the Mount Sinai School of Medicine, New York, NY, USA. He has held a professorship in Haematology at the Faculty of Medicine, University of Basel, Switzerland since 2004 and serves also as a visiting Professor of Hematology at the Medical School of the Aristotle University of Thessaloniki. He has served as Head of Haemostasis since 2009 and Head of Diagnostic Haematology and Haemostasis (2014-2021), as well as member of the Stem Cell Transplant and Cell-Therapy Center Basel at the University Hospital Basel, Switzerland. Since 2021 he has been Director of Thrombosis and Haemostasis and Co-Head Hematology at SYNLAB Suisse SA, Switzerland. His main fields of scientific interests are platelet activation, platelet disorders, diagnosis and treatment of bleeding disorders and thrombophilia, disorders of haemostasis and endothelial cells after stem cell transplants. He has presented over 140 peer-reviewed original articles and reviews.

As a laboratory specialist, hematologist, and epidemiologist, Michael Nagler has a wide range of training and expertise. Currently, he is the deputy director of the Centre for Laboratory Medicine at Inselspital University Hospital in Switzerland and an associate professor at the University of Bern. The focus of his research is one of the most common clinical questions: “What does this laboratory test result mean for the individual patient?” To strive in this, he advances diagnostic research methodologies, validates and implements new testing strategies, and develops creative decision support tools, specifically diagnostic machine learning algorithms.

Programme summary
Listen to the podcast now
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Monitoring Anticoagulation: Yes or No?

A clinical discussion on anticoagulation monitoring

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HEMOSTASIS CONNECT

HEMOSTASIS CONNECT is an initiative of COR2ED, supported by Independent Medical Educational Grants from Pfizer, Takeda, Viatris and Pentapharm.

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