<i>HER2</i>-mutant NSCLC: Video

Drs Herbert Loong and Isabel Preeshagul join us live from ASCO 2026 to share their thoughts on the latest data in HER2-mutant non-small cell lung cancer (NSCLC) presented at the meeting. 

 

Watch the video to get their expert views and perspectives on the following abstracts:

 

  • SOHO-01: Updated safety and efficacy of sevabertinib in patients with advanced HER2-mutant NSCLC. Loong H, et al. Abstract 8622, ASCO 2026 
  • Beamion LUNG-3: Zongertinib in resectable HER2-mutant NSCLC. Cummings A, et al. Abstract TPS8129, ASCO 2026 
  • Best practices in HER2 testing: Advancing HER2 testing and evidence-based treatment in NSCLC: A quality improvement initiative across academic and community settings. McKinnon K.E, et al. Abstract e23309, ASCO 2026 
  • PRO results from the Beamion LUNG-1 trial in treatment-naïve patients with HER2-mutant advanced NSCLC. Sabari J.K, et al. Abstract 8616, ASCO 2026 

 

Want to know more about the data? View and download the accompanying slides on the 'Slides' tab for a deeper dive.

  • Understand the clinical trial data and emerging profiles of therapies for the treatment of molecularly driven lung cancer, including treatments for HER2 directed NSCLC

Dr Herbert H. Loong holds conjoint appointments of Clinical Associate Professor in the Department of Clinical Oncology and Deputy Medical Director of the Phase 1 Clinical Trials Centre of The Chinese University of Hong Kong.

 

Dr Loong obtained his medical degree with a Distinction in Surgery from The University of Hong Kong in 2003. He has completed a Fellowship in Drug Development at Princess Margaret Cancer Centre in Toronto, Canada with a focus on Experimental Therapeutics. His clinical and research interests include Thoracic Oncology, Sarcoma Medical Oncology and Health Economics.

 

Dr Loong is a recipient of the European Cancer Congress Fellowship Grant (2013), the American Society of Clinical Oncology (ASCO) Annual Meeting Merit Award (2014), the Hong Kong College of Physicians Young Investigators’ Award (2014). Dr. Loong led the Lung Cancer Team at CUHK to be bestowed the IASLC Foundation Cancer Care Team Award in recognition for providing the best thoracic oncology care in “Asia & Rest of the World” in 2018.

 

In recent years, Dr Loong has co-founded the Asia Pacific Oncology Drug Development Consortium (APODDC) and the Asia Pacific Coalition Against Lung Cancer (APCLC).

 

Dr Loong has served or continues to serve in various capacities in various professional international oncology bodies, including the International Affairs Committee and the Asia-Pacific Regional Council of ASCO, the Membership, Education and Communications Committees of the IASLC. He is the incoming Chairman of the International Affairs Committee of ASCO in 2024. He has been elected as a Board Member of the Connective Tissue Oncology Society (CTOS) for 2022-2024. In his prior appointment as a member of Pharmacy and Poisons Board of Hong Kong, he oversaw the registration of medicinal products and clinical trials in the territory.

Dr Herbert Loong has received financial support/sponsorship for research support, consultation, or speaker fees from the following companies:

AbbVie, Amgen, Bayer, Boehringer-Ingelheim, Celgene, Eisai, Eli-Lilly, George Clinical, Guardant Health, Illumina, Janssen, Novartis, Merck Sereno, Pfizer, Takeda

Dr Preeshagul is an assistant attending on the thoracic medical oncology service at MSKCC. She has a strong interest in patient centered clinical trials, precision medicine and patient education. She currently serve as the chair of the Lung Cancer Research Foundation’s (LCRF) Education & Engagement Committee as well as the host of their monthly “Together Separately” webinar offering various education sessions recapping ASCO, clinical trials 101 and more. Her work with LCRF has led to many exciting projects regarding patient advocacy. At MSKCC she lead the Clinical Research Leadership Group, focusing on optimising research in MSKCCs regional care network by identifying challenges, implementing new workflows and assessing how that impacts patient care.

Dr Isabel Preeshagul has received financial support/sponsorship for research support, consultation, or speaker fees from the following companies:

AstraZeneca, DAVAoncology, Genentech, Lab Corp, Novartis, Pfizer, Takeda

<i>HER2</i>-mutant NSCLC: Slides

Drs Herbert Loong and Isabel Preeshagul join us live from ASCO 2026 to share their thoughts on the latest data in HER2-mutant non-small cell lung cancer (NSCLC) presented at the meeting. 

 

Watch the video to get their expert views and perspectives on the following abstracts:

 

  • SOHO-01: Updated safety and efficacy of sevabertinib in patients with advanced HER2-mutant NSCLC. Loong H, et al. Abstract 8622, ASCO 2026 
  • Beamion LUNG-3: Zongertinib in resectable HER2-mutant NSCLC. Cummings A, et al. Abstract TPS8129, ASCO 2026 
  • Best practices in HER2 testing: Advancing HER2 testing and evidence-based treatment in NSCLC: A quality improvement initiative across academic and community settings. McKinnon K.E, et al. Abstract e23309, ASCO 2026 
  • PRO results from the Beamion LUNG-1 trial in treatment-naïve patients with HER2-mutant advanced NSCLC. Sabari J.K, et al. Abstract 8616, ASCO 2026 

 

To dive deeper into the data, download the slide set for your own reference. Don't forget to watch the video update in the 'Video' tab.

  • Understand the clinical trial data and emerging profiles of therapies for the treatment of molecularly driven lung cancer, including treatments for HER2 directed NSCLC

Dr Herbert H. Loong holds conjoint appointments of Clinical Associate Professor in the Department of Clinical Oncology and Deputy Medical Director of the Phase 1 Clinical Trials Centre of The Chinese University of Hong Kong.

 

Dr Loong obtained his medical degree with a Distinction in Surgery from The University of Hong Kong in 2003. He has completed a Fellowship in Drug Development at Princess Margaret Cancer Centre in Toronto, Canada with a focus on Experimental Therapeutics. His clinical and research interests include Thoracic Oncology, Sarcoma Medical Oncology and Health Economics.

 

Dr Loong is a recipient of the European Cancer Congress Fellowship Grant (2013), the American Society of Clinical Oncology (ASCO) Annual Meeting Merit Award (2014), the Hong Kong College of Physicians Young Investigators’ Award (2014). Dr. Loong led the Lung Cancer Team at CUHK to be bestowed the IASLC Foundation Cancer Care Team Award in recognition for providing the best thoracic oncology care in “Asia & Rest of the World” in 2018.

 

In recent years, Dr Loong has co-founded the Asia Pacific Oncology Drug Development Consortium (APODDC) and the Asia Pacific Coalition Against Lung Cancer (APCLC).

 

Dr Loong has served or continues to serve in various capacities in various professional international oncology bodies, including the International Affairs Committee and the Asia-Pacific Regional Council of ASCO, the Membership, Education and Communications Committees of the IASLC. He is the incoming Chairman of the International Affairs Committee of ASCO in 2024. He has been elected as a Board Member of the Connective Tissue Oncology Society (CTOS) for 2022-2024. In his prior appointment as a member of Pharmacy and Poisons Board of Hong Kong, he oversaw the registration of medicinal products and clinical trials in the territory.

Dr Herbert Loong has received financial support/sponsorship for research support, consultation, or speaker fees from the following companies:

AbbVie, Amgen, Bayer, Boehringer-Ingelheim, Celgene, Eisai, Eli-Lilly, George Clinical, Guardant Health, Illumina, Janssen, Novartis, Merck Sereno, Pfizer, Takeda

Dr Preeshagul is an assistant attending on the thoracic medical oncology service at MSKCC. She has a strong interest in patient centered clinical trials, precision medicine and patient education. She currently serve as the chair of the Lung Cancer Research Foundation’s (LCRF) Education & Engagement Committee as well as the host of their monthly “Together Separately” webinar offering various education sessions recapping ASCO, clinical trials 101 and more. Her work with LCRF has led to many exciting projects regarding patient advocacy. At MSKCC she lead the Clinical Research Leadership Group, focusing on optimising research in MSKCCs regional care network by identifying challenges, implementing new workflows and assessing how that impacts patient care.

Dr Isabel Preeshagul has received financial support/sponsorship for research support, consultation, or speaker fees from the following companies:

AstraZeneca, DAVAoncology, Genentech, Lab Corp, Novartis, Pfizer, Takeda

Lung cancer

Prof. Mark Socinski is joining us at ASCO 2026 to share his views on the latest breaking lung cancer data coming from the congress.

 

Could data from the following trials impact your clinical practice? Come back soon to watch the video and find out!

  • LIBRETTO-432: Event-free survival with adjacent selpercatinib in stage IB-IIIA RET fusion-positive NSCLC: Primary results of the phase 3 LIBRETTO-432 trial. Taplin M-E, et al.  Abstract LBA3, ASCO 2026
  • HARMONi-5: Ivonescimab plus chemotherapy versus tislelizumab plus chemotherapy in previously untreated advanced squamous NSCLC: Overall survival results of the phase 3 HARMONi-5 trial. Goldman J.W, et al. Abstract LBA4, ASCO 2026
  • WU-KONG28: Sunvozertinib monotherapy versus platinum-based chemotherapy as 1st line treatment for advanced NSCLC with EGFR exon20ins: Primary analysis of a multinational phase 3 randomised study (WU-KONG28). Heymach J.V, et al. Abstract LBA8500, ASCO 2026

Prof. Mark Socinski is a Medical Oncologist and Executive Medical Director of the AdventHealth Cancer Institute, Orlando, Florida. Specialises in all thoracic malignancies, including small cell and non-small cell lung cancers and mesothelioma. An internationally recognised expert in the development of novel chemotherapy agents and treatment strategies for advanced non-small cell lung cancer and small cell lung cancer. Research has focused on incorporating personalised medicine and molecular biomarkers in the treatment of lung cancer. Formerly Co-Chair of the Thoracic Malignancies Steering Committee for the National Cancer Institute and served on the Respiratory Core Committee of the Cancer and Leukemia Group B (Alliance). Tenured Professor at the University of North Carolina and the University of Pittsburgh.

Prof. Mark Socinski has received financial support/sponsorship for research support, consultation, or speaker fees from the following companies:

AstraZeneca, Beigene, BMS, Cullinan, Eli Lilly, Genentech, GI Therapeutics, Guardant, Janssen, Jazz, Merck, Novartis, OncoC4, Regeneron, Spectrum, Summit

Dr Preeshagul is an assistant attending on the thoracic medical oncology service at MSKCC. She has a strong interest in patient centered clinical trials, precision medicine and patient education. She currently serve as the chair of the Lung Cancer Research Foundation’s (LCRF) Education & Engagement Committee as well as the host of their monthly “Together Separately” webinar offering various education sessions recapping ASCO, clinical trials 101 and more. Her work with LCRF has led to many exciting projects regarding patient advocacy. At MSKCC she lead the Clinical Research Leadership Group, focusing on optimising research in MSKCCs regional care network by identifying challenges, implementing new workflows and assessing how that impacts patient care.

Dr Isabel Preeshagul has received financial support/sponsorship for research support, consultation, or speaker fees from the following companies:

AstraZeneca, DAVAoncology, Genentech, Lab Corp, Novartis, Pfizer, Takeda

Dr Herbert H. Loong holds conjoint appointments of Clinical Associate Professor in the Department of Clinical Oncology and Deputy Medical Director of the Phase 1 Clinical Trials Centre of The Chinese University of Hong Kong.

 

Dr Loong obtained his medical degree with a Distinction in Surgery from The University of Hong Kong in 2003. He has completed a Fellowship in Drug Development at Princess Margaret Cancer Centre in Toronto, Canada with a focus on Experimental Therapeutics. His clinical and research interests include Thoracic Oncology, Sarcoma Medical Oncology and Health Economics.

 

Dr Loong is a recipient of the European Cancer Congress Fellowship Grant (2013), the American Society of Clinical Oncology (ASCO) Annual Meeting Merit Award (2014), the Hong Kong College of Physicians Young Investigators’ Award (2014). Dr. Loong led the Lung Cancer Team at CUHK to be bestowed the IASLC Foundation Cancer Care Team Award in recognition for providing the best thoracic oncology care in “Asia & Rest of the World” in 2018.

 

In recent years, Dr Loong has co-founded the Asia Pacific Oncology Drug Development Consortium (APODDC) and the Asia Pacific Coalition Against Lung Cancer (APCLC).

 

Dr Loong has served or continues to serve in various capacities in various professional international oncology bodies, including the International Affairs Committee and the Asia-Pacific Regional Council of ASCO, the Membership, Education and Communications Committees of the IASLC. He is the incoming Chairman of the International Affairs Committee of ASCO in 2024. He has been elected as a Board Member of the Connective Tissue Oncology Society (CTOS) for 2022-2024. In his prior appointment as a member of Pharmacy and Poisons Board of Hong Kong, he oversaw the registration of medicinal products and clinical trials in the territory.

Dr Herbert Loong has received financial support/sponsorship for research support, consultation, or speaker fees from the following companies:

AbbVie, Amgen, Bayer, Boehringer-Ingelheim, Celgene, Eisai, Eli-Lilly, George Clinical, Guardant Health, Illumina, Janssen, Novartis, Merck Sereno, Pfizer, Takeda

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Prostate cancer

Prof. Evan Yu will join us in Chicago to offer his perspective on the latest news in prostate cancer as it emerges from this year’s ASCO Annual Meeting.

 

He is expected to review new data from the following key studies:

  • PROTEUS: Perioperative (neoadjuvant and adjuvant) apalutamide + ADT vs placebo + ADT with radical prostatectomy in high-risk localised or locally advanced prostate cancer - Final analysis of the PROTEUS phase 3 study. Taplin M-E, et al. Abstract LBA1, ASCO 2026
  • TALAPRO-3: Talazoparib + enzalutamide compared with placebo + enzalutamide for the treatment of patients with mCSPC harbouring HRR gene alteration. Agarwal N, et al. Abstract LBA5007, ASCO 2026

 

We'll be sharing Prof. Yu's video as soon as possible, so check back soon for updates.

Dr. Evan Y. Yu is a medical oncologist specializing in genitourinary malignancies, specifically prostate, bladder and testicular cancer treatment and research. His research focuses on testing the next wave of novel molecular targeted therapies and immunotherapy techniques, with a complementary focus on imaging biomarkers. He is Section Head, Medical Oncology in the Clinical Research Division at Fred Hutch Cancer Center. He also serves as the Medical Director for Clinical Research for the Fred Hutch/University of Washington/Seattle Children’s Cancer Consortium. He is a Professor at the University of Washington and Fred Hutch Cancer Center. He is principal investigator for the National Cancer Trials Network Lead Academic Performance Site (LAPS) Grant, SWOG, and ECOG/ACRIN. Dr. Yu is also the core director for the Pacific Northwest Prostate Cancer SPORE and co-PI of the DoD Prostate Cancer Clinical Trials Consortium for his institution. He graduated Alpha Omega Alpha from the University of Washington School of Medicine. Previously, he served as a Hematology/Oncology Fellowship Program Director for a decade at Fred Hutch. He has regularly been voted a “Top Doctor” by Castle Connolly, Seattle Magazine, and Seattle Met magazine. He has served for many years on the National Cancer Institute Genitourinary Cancers Steering Committee and is currently the co-chair for the National Cancer Institute Prostate Cancer Task Force. Dr. Yu has held various leadership/committee roles within ASCO, AACR, and also serves as a senior editor for Clinical Cancer Research and Uro-Today.

Dr. Evan Y. Yu is a medical oncologist specializing in genitourinary malignancies, specifically prostate, bladder and testicular cancer treatment and research. His research focuses on testing the next wave of novel molecular targeted therapies and immunotherapy techniques, with a complementary focus on imaging biomarkers. He is Section Head, Medical Oncology in the Clinical Research Division at Fred Hutch Cancer Center. He also serves as the Medical Director for Clinical Research for the Fred Hutch/University of Washington/Seattle Children’s Cancer Consortium. He is a Professor at the University of Washington and Fred Hutch Cancer Center. He is principal investigator for the National Cancer Trials Network Lead Academic Performance Site (LAPS) Grant, SWOG, and ECOG/ACRIN. Dr. Yu is also the core director for the Pacific Northwest Prostate Cancer SPORE and co-PI of the DoD Prostate Cancer Clinical Trials Consortium for his institution. He graduated Alpha Omega Alpha from the University of Washington School of Medicine. Previously, he served as a Hematology/Oncology Fellowship Program Director for a decade at Fred Hutch. He has regularly been voted a “Top Doctor” by Castle Connolly, Seattle Magazine, and Seattle Met magazine. He has served for many years on the National Cancer Institute Genitourinary Cancers Steering Committee and is currently the co-chair for the National Cancer Institute Prostate Cancer Task Force. Dr. Yu has held various leadership/committee roles within ASCO, AACR, and also serves as a senior editor for Clinical Cancer Research and Uro-Today.

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GI & hepatobiliary cancer

Prof. Hans Prenen will join us at this year's ASCO Annual Meeting to talk through late-breaking data on colorectal cancer (CRC), pancreatic cancer, and liver cancer. His video will be released as soon as possible; don't miss it!

 

Prof. Prenen could review data from the following:

  • EMERALD-3: Efficacy and safety results from EMERALD-3: A phase 3, randomised study of tremelimumab plus durvalumab with or without lenvatinib combined with TACE in participants with unresectable embolisation-eligible HCC. Abou-Alfa G.K, et al. Abstract LBA4000, ASCO 2026
  • BREAKWATER: Progression-free and overall survival analyses of first-line encorafenib + cetuximab + FOLFIRI in BRAFⱽ⁶⁰⁰ᴱ mutant mCRC. Kopetz S, et al. Abstract LBA3503, ASCO 2026
  • RASolute 302: Daraxonrasib, a RAS(ON) multi-selective inhibitor vs chemotherapy in previously treated mPDAC: Primary and final analysis from the phase 3 RASolute 302 study. Wolpin B.M., et al. Abstract LBA5, ASCO 2026

Hans Prenen obtained his medical degree and PhD at the Catholic University Leuven. He is currently the head of the Medical Oncology Department at the University Hospital Antwerp and director of the Oncology Clinical Trial Unit. He is member of several scientific organisations including the Belgian Society of Medical Oncology (board member since 2015) and the European Society of Medical oncology (scientific committee). He is a recognised international expert in the field of cancer and is regularly invited to national and international meetings and has published more than 200 peer reviewed scientific papers. He is principal investigator of several clinical trials with a focus on phase 1 and basket trials. His research interests relate to translational studies on targeted therapies, new anticancer therapies and understanding the molecular changes induced by anticancer therapy.

Prof. Hans Prenen has received financial support/sponsorship for research support, consultation, or speaker fees from the following companies:

Amgen, AstraZeneca, Biocartis, Merck

Hans Prenen obtained his medical degree and PhD at the Catholic University Leuven. He is currently the head of the Medical Oncology Department at the University Hospital Antwerp and director of the Oncology Clinical Trial Unit. He is member of several scientific organisations including the Belgian Society of Medical Oncology (board member since 2015) and the European Society of Medical oncology (scientific committee). He is a recognised international expert in the field of cancer and is regularly invited to national and international meetings and has published more than 200 peer reviewed scientific papers. He is principal investigator of several clinical trials with a focus on phase 1 and basket trials. His research interests relate to translational studies on targeted therapies, new anticancer therapies and understanding the molecular changes induced by anticancer therapy.

Prof. Hans Prenen has received financial support/sponsorship for research support, consultation, or speaker fees from the following companies:

Amgen, AstraZeneca, Biocartis, Merck

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Breast cancer

We're meeting with Dr Paolo Tarantino at ASCO 2026 to get his thoughts on the new breast cancer data that emerge from the congress. Will the new developments influence your current daily practice? Keep checking back here to get the answer as soon as the video is released.

 

Dr Tarantino is expected to review data from the following trials:

  • persevERA: Giredestrant + palbociclib vs letrozole + palbociclib as 1st line therapy in patients with ER+, HER2– LA/mBC: Primary analysis of the phase 3 persevERA BC trial. Turner N, et al. Abstract LBA1006, ASCO 2026 
  • SERENA-6: 1st line camizestran for emergent ESR1 mutations in advanced BC: Final progression-free survival 2 from the phase 3 SERENA-6 trial. Bidard F.C, et al. Abstract LBA1007, ASCO 2026
  • ASCENT-04: Progression-free survival after next line of treatment and subsequent therapies in the ASCENT-04 study of participants with previously untreated PD-L1+ mTNBC treated with sacituzumab govitecan plus pembrolizumab vs chemotherapy plus pembro. Kalinsky K, et al. Abstract LBA1000, ASCO 2026

Paolo Tarantino is a leading researcher in the field of breast cancer and drug development. He’s currently pursuing an advanced research fellowship at Dana Farber Cancer Institute and at Harvard Medical School (Boston, MA) and a PhD in clinical research at the University of Milan. His research focuses on the study of the HER2 oncoprotein, the biology of HER2-low breast tumors and the development of novel antibody-drug conjugates.

Dr Paolo Tarantino has received financial support/sponsorship for research support, consultation, or speaker fees from the following companies:

Dr. Tarantino decleares advisory role, speakers fees and/or research support from: AstraZeneca, Daiichi Sankyo, Lilly and Gilead.

Paolo Tarantino is a leading researcher in the field of breast cancer and drug development. He’s currently pursuing an advanced research fellowship at Dana Farber Cancer Institute and at Harvard Medical School (Boston, MA) and a PhD in clinical research at the University of Milan. His research focuses on the study of the HER2 oncoprotein, the biology of HER2-low breast tumors and the development of novel antibody-drug conjugates.

Dr Paolo Tarantino has received financial support/sponsorship for research support, consultation, or speaker fees from the following companies:

Dr. Tarantino decleares advisory role, speakers fees and/or research support from: AstraZeneca, Daiichi Sankyo, Lilly and Gilead.

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Cette vidéo est soutenue par une subvention indépendante à visée éducative d’Ipsen.  Les contenus publiés sur ce site internet sont sous la responsabilité de leurs auteurs. Certaines données scientifiques publiées sur ce site sont susceptibles de ne pas être validées par la commission d’Autorisation de Mise sur le Marché, et ne doivent pas être mises en pratique. Elles doivent être lues et comprises avec le plus grand discernement et sont données dans leur cadre de la diffusion de l’information sur l’état actuel de la recherche auprès de la communauté scientifique internationale  
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episode
Oncology Rare diseases Endocrinology 
Update from ENETS 2026

Experts share their views on latest data in neuroendocrine cancer

Experts
Prof. Louis de Mestier, Prof. Timon Vandamme, Dr Alice Durand
  • clock 5 MIN
  • calendar Mar 2026
  • Non-accredited Independent Medical Education

This educational programme is supported by an Independent Educational Grant from Ipsen. The content published on this website is under the responsibility of its authors. Some scientific data published on this website may not have been validated by the relevant Marketing Authorisation Committees and should not be put into practice. It should be read and understood with the utmost discernment and is provided for the purpose of disseminating information on the current state of research to the international scientific community.
patient-support Patient Support
Oncology Hemato-oncology Pediatrics 
Personalised treatment in childhood cancer: A journey through NTRK fusion testing

Experts
Linet Menachery
Endorsed by
NTRKers ICAN international cancer advocacy network Biomarker Collaborative
  • clock 4 MIN
  • calendar Mar 2026
  • Non-accredited Independent Medical Education

Educational programme supported by an Independent Educational Grant from Bayer.