Prof. Viktor Grünwald joined us at ESMO 2025 to share his insights into how new data presented at the meeting may impact clinical practice.
Watch the video update to hear Prof. Grünwald report on advanced renal cell carcinoma data from the LenCabo, KEYMAKER-U03 and CLEAR studies and review the use of [68 Ga]Ga-DPI-4452 for staging of disease.
- LenCabo: A randomised, phase 2, multicentre trial of lenvatinib plus everolimus vs cabozantinib in patients with metastatic ccRCC that progressed on PD-1 immune checkpoint inhibition. Hahn A, et al. Abstract LBA94, ESMO 2025
- KEYMAKER-U03: First-line pembrolizumab-based regimens for advanced ccRCC: substudy 03A. Suarez Rodriguez C, et al. Abstract LBA96, ESMO 2025
- CLEAR: Final analysis of lenvatinib + pembrolizumab vs sunitinib in patients with aRCC with or without bone metastases in CLEAR. Porta CG, et al. Abstract 2603P, ESMO 2025
- CAIX PET/CT: [68Ga]Ga-DPI-4452 (CAIX) PET/CT for staging of patients with ccRCC. Küper AT, et al. Abstract 2597MO, ESMO 2025
Clinical takeaways
- LenCabo: demonstrates the efficacy of lenvatinib + everolimus for ICI pre-treated RCC patients with improved PFS & ORR compared with cabozantinib, although with higher toxicity. This combination should be considered for patients needing rapid or high tumour response, for whom the higher toxicity rate is acceptable
- CLEAR: Lenvatinib + pembrolizumab demonstrated improved efficacy versus sunitinib in advanced RCC, regardless of the presence or absence of bone metastases and continues to be a standard of care treatment in this population
- KEYMAKER-U03: Among various combinations tested, adding belzutifan (a HIF-2α inhibitor) to lenvatinib and pembrolizumab was the only regimen with improved PFS, response durability, and OS—supporting advancement to phase 3 trials as a promising new triplet for 1st-line RCC
- CAIX PET/CT: Ga-DPI PET provides high-resolution, tumour-specific imaging in clear cell RCC, enhancing distinction between oligometastatic and widespread disease and enabling more precise selection for multimodality treatments
View or download Prof. Grünwald's accompanying slides for more detailed insights.







Downloadable
5 MIN
Nov 2025
