You can now access the on-demand resources from a virtual Experts Knowledge Share on multiple myeloma, chaired by Prof. Karthik Ramasamy (UK), and co-chaired by Dr Joshua Richter (US), Dr Andrew Charlton (UK), and Dr Faisal Basheer (UK).
Topics of conversation include:
- Myeloma, bench to bedside: considerations at each line of therapy
- Every move matters: rethinking sequencing strategies in modern myeloma
- Clinical studies to clinical reality: patient case studies discussion
Watch the on-demand video from the meeting and download the accompanying slides.
Clinical takeaways
- Multiple myeloma evolves as a multi-clonal disease leading to resistance and refractoriness to multiple agents over time, creating a persistent unmet clinical need
- Despite therapeutic advances, there is a need for new drugs with different modes of action, e.g. XPO1 inhibition
- Careful consideration is required in how to sequence novel emerging T-cell engaging therapies optimally with existing treatments to maximise long-term outcomes
- Pre-clinical data have shown that selinexor has the potential to promote T-cell fitness and reduce T-cell exhaustion
- In the real-world setting, selinexor can be effective and its toxicities manageable, even in poor-prognosis settings such as lenalidomide-refractory disease:
- Median PFS with SVd vs Vd in Len-refractory multiple myeloma patients was 10.2 months vs 7.1 months, respectively
- Median OS with SVd vs Vd in Len-refractory multiple myeloma patients was 26.7 months vs 18.6 months, respectively
5 MIN
Mar 2026
Downloadable
