PARP inhibition and DNA Damage Response (DDR)

A comprehensive resource available via ESMO OncologyPRO

A comprehensive resource developed by experts Prof. Simon Boulton, Prof. Charlie Gourley, Dr. Judith Balmaña and Dr. Violeta Serra, available via ESMO OncologyPRO portal, covering the following areas in detail:

• Mechanism of Action (MoA) targeting DDR

• MoA of PARP inhibitors (being the proof of concept for targeting DDR)

• Clinical efficacy and safety/tolerability profile of PARP inhibitors and their benefit in various tumour types, now and in the future

• Patient selection for PARP inhibition: diagnostics involved in DDR

• Potential combination strategies with PARP inhibitors

• Potential future applications for DDR

The information is primarily directed at healthcare professionals and contains information regarding the rationale for targeting DDR, including PARP inhibition as the proof of concept, the current role of PARP inhibition in clinical practice, and the potential future application of targeting DDR in clinical practice.

However, there is also a helpful section for patients and caregivers on the two novel types of targeted cancer drugs known as DDR (DNA damage response)-targeting agents and PARP (poly-ADP ribose polymerase) inhibitors with information on how these drugs work and how patients can work with their healthcare professional to manage any changes that may occur during treatment.

COR2ED have donated this content to ESMO to ensure that this comprehensive guide reflects today's best clinical practice in PARP inhibition and DNA Damage Response.