In this micro learning module developed by experts Dr Devika Das and Dr Tom Newsom-Davis, you will learn about the rapidly changing treatment landscape for patients with HER2-mutant non-small cell lung cancer (NSCLC).
This module features a concise animated video, downloadable resources, and an assessment to evaluate your understanding.
Topics include:
- The importance of early identification of HER2-mutant NSCLC and the clinical significance of these alterations
- Clinical trial evidence for HER2-targeted therapies, including antibody-drug conjugates and next-generation tyrosine kinase inhibitors
- Safety profiles and toxicity management strategies for HER2-directed treatments
- Evolving treatment landscape, including sequencing and emerging therapeutic approaches
Micro learning programmes offer concise, easily digestible resources, each lasting under five minutes to watch or read. If you have extra time, complete the short assessment and earn CME credit in just 30 minutes.
Clinical takeaways
- Test early and accurately: Next generation sequencing (NGS) is required to identify HER2 mutations and guide therapy
- Targeted therapies improve outcomes: Antibody-drug conjugates (ADCs), such as trastuzumab deruxtecan and next-generation tyrosine kinase inhibitors (TKIs) (zongertinib, sevabertinib), show high response rates, durable responses, and activity in patients with brain metastases
- Manage toxicities proactively: ADCs carry interstitial lung disease risk; TKIs mainly cause low-grade diarrhea and rash, manageable with supportive care and dose adjustments
- Thoughtful sequencing of HER2-targeted therapies: may help optimise outcomes, particularly when used earlier in the treatment pathway, considering central nervous system involvement, efficacy, safety, and patient factors

Downloadable
5 MIN
Jun 2026
