In this video, Prof. María-Victoria Mateos examines the strategic role of selinexor in the evolving relapsed/refractory multiple myeloma (RRMM) landscape, focusing on how its unique XPO1 inhibition addresses the challenge of early refractoriness to lenalidomide and anti-CD38 therapies, as well as its place in sequencing T-cell-directed therapies.
She explores the clinical benefits of this antigen-independent mechanism, highlighting its efficacy in difficult-to-treat subgroups and its ability to preserve T-cell fitness for future treatment lines.
Key insights include:
- Clinical efficacy: The role of selinexor in 2nd line and 3rd line settings for patients with high unmet needs, particularly Len-refractory and anti-CD38-refractory patients
- Strategic sequencing: How selinexor-based regimens (SVd) can help optimise the use of subsequent BCMA-targeted therapies
- Practical management: Expert guidance on managing a predictable safety profile as well as effective dosing strategies (80–100 mg) to ensure treatment adherence
Clinical takeaways
- Selinexor addresses the unmet needs of difficult-to-treat RRMM patients by providing a unique therapeutic option in early relapse settings
- Selinexor’s non-BCMA-dependent MoA reserves BCMA-targeted therapies for later lines of treatment, while its immunomodulatory effects potentially improve their efficacy
- Selinexor has a predictable safety profile and manageable adverse events (AEs)
- Balance efficacy and tolerability in the SVd regimen with a selinexor starting dose of 80 to 100 mg
Downloadable
5 MIN
Jul 2026
