In this video, Prof. María-Victoria Mateos examines the strategic role of selinexor in the evolving relapsed/refractory multiple myeloma (RRMM) landscape, focusing on how its unique XPO1 inhibition addresses the challenge of early refractoriness to lenalidomide and anti-CD38 therapies, as well as its place in sequencing T-cell-directed therapies.

 

She explores the clinical benefits of this antigen-independent mechanism, highlighting its efficacy in difficult-to-treat subgroups and its ability to preserve T-cell fitness for future treatment lines.

 

Key insights include:

 

  • Clinical efficacy: The role of selinexor in 2nd line and 3rd line settings for patients with high unmet needs, particularly Len-refractory and anti-CD38-refractory patients
  • Strategic sequencing: How selinexor-based regimens (SVd) can help optimise the use of subsequent BCMA-targeted therapies
  • Practical management: Expert guidance on managing a predictable safety profile as well as effective dosing strategies (80–100 mg) to ensure treatment adherence

 

 


Clinical takeaways

  • Selinexor addresses the unmet needs of difficult-to-treat RRMM patients by providing a unique therapeutic option in early relapse settings
  • Selinexor’s non-BCMA-dependent MoA reserves BCMA-targeted therapies for later lines of treatment, while its immunomodulatory effects potentially improve their efficacy
  • Selinexor has a predictable safety profile and manageable adverse events (AEs)
  • Balance efficacy and tolerability in the SVd regimen with a selinexor starting dose of 80 to 100 mg
  • Understand the challenges associated with the evolving landscape of RRMM
  • Describe the MoA of XPO1 inhibition, its efficacy in different subgroups, as well as the importance of sequencing with BCMA-targeted therapies
  • Understand selinexor safety and dosing

Dr María-Victoria Mateos, MD, PhD, is Consultant Physician in the Haematology Department and Associate Professor of Medicine at the University of Salamanca, Spain.

 

She is the director of the Myeloma Program and coordinates the Clinical Trials Unit in Salamanca’s University Hospital Haematology Department. She serves as coordinator of GEM (Spanish Myeloma Group), with direct involvement in the design and development of clinical trials. She has coordinated many clinical trials especially in the smouldering myeloma setting and these trials have profoundly influenced current options for the management of these patient populations.

 

She has published over 250 original papers in international journals and her articles had received 29.452 citations (19268 since 2015) with a H index of 79 and 60 since 2015.

 

She is also a member of the IMWG (International MM Working Group), IMS (International MM Society), EHA and ASH. Among her invited presentations, she has contributed to the educational sessions of EHA 2012, ASH 2013, ASCO 2015, EHA 2016, ASCO and ASH 2017. She has served on the ASH Scientific Committee on plasma cell diseases between 2015-2019 and on the EHA’s Scientific Program Committee and Advisory Board since 2013 until 2020 being chair of the Scientific Program Committee in 2019, and. She has been Councillor on the EHA Board since 2015 for a four-year mandate, member of the Steering Committee for the Society of Hematologic Oncology (SOHO), member of the IMS board and member of the European School of Haematology (ESH) Scientific committee.

 

She received the Briand Durie Award in 2019 recognizing excellence in myeloma research.

Prof. María Victoria Mateos has received financial support/sponsorship for research support, consultation, or speaker fees from the following companies:

J&J, BMS, Amgen, GSK, Sanofi, Pfizer, Regeneron, Menarini Stemline, Roche, Kite, Oncopeptides, Eli Lilly 

In this video, Prof. María-Victoria Mateos examines the strategic role of selinexor in the evolving relapsed/refractory multiple myeloma (RRMM) landscape, focusing on how its unique XPO1 inhibition addresses the challenge of early refractoriness to lenalidomide and anti-CD38 therapies, as well as its place in sequencing T-cell-directed therapies.

 

She explores the clinical benefits of this antigen-independent mechanism, highlighting its efficacy in difficult-to-treat subgroups and its ability to preserve T-cell fitness for future treatment lines.

 

Key insights include:

 

  • Clinical efficacy: The role of selinexor in 2nd line and 3rd line settings for patients with high unmet needs, particularly Len-refractory and anti-CD38-refractory patients
  • Strategic sequencing: How selinexor-based regimens (SVd) can help optimise the use of subsequent BCMA-targeted therapies
  • Practical management: Expert guidance on managing a predictable safety profile as well as effective dosing strategies (80–100 mg) to ensure treatment adherence

 

 


Clinical takeaways

  • Selinexor addresses the unmet needs of difficult-to-treat RRMM patients by providing a unique therapeutic option in early relapse settings
  • Selinexor’s non-BCMA-dependent MoA reserves BCMA-targeted therapies for later lines of treatment, while its immunomodulatory effects potentially improve their efficacy
  • Selinexor has a predictable safety profile and manageable adverse events (AEs)
  • Balance efficacy and tolerability in the SVd regimen with a selinexor starting dose of 80 to 100 mg
  • Understand the challenges associated with the evolving landscape of RRMM
  • Describe the MoA of XPO1 inhibition, its efficacy in different subgroups, as well as the importance of sequencing with BCMA-targeted therapies
  • Understand selinexor safety and dosing

Dr María-Victoria Mateos, MD, PhD, is Consultant Physician in the Haematology Department and Associate Professor of Medicine at the University of Salamanca, Spain.

 

She is the director of the Myeloma Program and coordinates the Clinical Trials Unit in Salamanca’s University Hospital Haematology Department. She serves as coordinator of GEM (Spanish Myeloma Group), with direct involvement in the design and development of clinical trials. She has coordinated many clinical trials especially in the smouldering myeloma setting and these trials have profoundly influenced current options for the management of these patient populations.

 

She has published over 250 original papers in international journals and her articles had received 29.452 citations (19268 since 2015) with a H index of 79 and 60 since 2015.

 

She is also a member of the IMWG (International MM Working Group), IMS (International MM Society), EHA and ASH. Among her invited presentations, she has contributed to the educational sessions of EHA 2012, ASH 2013, ASCO 2015, EHA 2016, ASCO and ASH 2017. She has served on the ASH Scientific Committee on plasma cell diseases between 2015-2019 and on the EHA’s Scientific Program Committee and Advisory Board since 2013 until 2020 being chair of the Scientific Program Committee in 2019, and. She has been Councillor on the EHA Board since 2015 for a four-year mandate, member of the Steering Committee for the Society of Hematologic Oncology (SOHO), member of the IMS board and member of the European School of Haematology (ESH) Scientific committee.

 

She received the Briand Durie Award in 2019 recognizing excellence in myeloma research.

Prof. María Victoria Mateos has received financial support/sponsorship for research support, consultation, or speaker fees from the following companies:

J&J, BMS, Amgen, GSK, Sanofi, Pfizer, Regeneron, Menarini Stemline, Roche, Kite, Oncopeptides, Eli Lilly 

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