Podcast episode 1: lower GI cancer

Dr Jenny Seligmann and Dr Dominik Modest discuss key abstracts on lower GI cancer from ESMO 2022 in Episode 1 of this podcast series. 

Podcast episode 2: upper GI cancer

In Episode 2, Dr Sam Klempner and invited expert Dr Yelena Janjigian discuss the upper GI cancer highlights from the congress.

Presidential session update

Dr Thomas Winder provides his perspectives on data presented at the presidential session  in a short video review.

Access both podcast episodes and the highlights video below


Dr. Thomas Winder provides a short review of the ESMO 2022 Presidential Session on NICHE-2 (Neoadjuvant Immune Checkpoint Inhibition in Locally Advanced MMR-deficient Colon Cancer).

Dear colleagues. My name is Thomas Winder. I'm a Medical Oncologist from Austria.

It's an honour and privilege to present to you today the NICHE-2 trial.

The NICHE-2 trial was presented at the presidential session at the ESMO 2022 meeting.

NICHE-2 is a neo-adjuvant immunotherapy trial in locally advanced colorectal cancer patients. So, they included in the intention-to-treat analysis 112 patients.

As you are aware around 10 to 15% of patients with locally advanced colorectal cancer are mismatch repair deficient. The recurrence rate of these patients is around 20 to 40 percent with standard treatment options.

So, in the NICHE-2 trial, they treated the patients in the neo-adjuvant setting with a combined treatment of nivolumab and ipilimumab followed by a single treatment with nivolumab followed by surgery.

The primary endpoint of the study was safety and efficacy defined by pathological response.

So now I want to present you the fascinating results of the study.

The study was safe and around 98% of the patients received surgery timely. And now the intriguing results on the pathological response. 95% of patients had a major pathological response and 67% of the patients had a complete pathological response.

These are intriguing results. They also presented the disease-free survival with the median follow-up of around 13 months, and there were no recurrences.

You need to keep in mind that in this setting around 40-50% of high-risk stage 3 colorectal cancer patients recur with standard treatment options. So, these results are really fascinating and potentially practice changing.

So, for the future they are now going to plan the NICHE-3 study maybe with a different immunotherapy compound and we are looking forward to these results. And we are looking forward to the further information we're going to get on this study, on the three-year disease-free survival, which we will await in 2023.

Dr Jenny Seligmann gained her MBChB and BMedSci at the University of Aberdeen in 2005 then gained her PhD in 2015 from the University of Leeds on Biomarkers of Prognosis and Prediction of Response in Colorectal Cancer. She was appointed a Cancer Research UK Clinical Trials Fellow in 2015, then a University Academic Fellow and Consultant in Medical Oncology in Leeds in 2017. Her research interests are in clinical trials and biomarkers of prediction of response in colorectal cancer. She is involved in several ongoing clinical trials, including the FOCUS-4 trial and has an ongoing lab-based programme of research. She has been involved in several national and international committees, including the UK Colorectal Clinical Studies Group and is currently the EORTC GI Group Young Investigator. She has received several awards including an ASCO Merit Award in 2013.

Prof. Jenny Seligmann has received financial support/sponsorship for research support, consultation, or speaker fees from the following companies:

Merck Serono, Pierre Fabre and Roche Diagnostics. 

Prof. Dr Dominik Modest studied medicine at the Charité in Berlin, Germany and at the University of Bern, Switzerland. Currently, after 10 years at the LMU in Munich, Germany, he is a physician at the Charité Universitaetsmedizin Berlin, Germany. His research activities focus on metastatic colorectal cancer and include the concept and coordination of trials for the FIRE study group and the Arbeitsgemeinschaft Internistische Onkologie (AIO). Prof. Dr Modest also coordinates the translational research components of these trials, aiming to identify prognostic and predictive biomarkers of metastatic colorectal cancer. His research has been published in several papers in scientific journals. In 2015, he received a postdoctoral qualification on factors for personalisation of metastatic colorectal cancer therapy and a full professorship in 2020.  Prof. Dr Modest is an active member of several national and international cancer associations and served as spokesman for the Young Medical Oncologists of the AIO until 2014.

Dr Dominik Modest has received financial support/sponsorship for research support, consultation, or speaker fees from the following companies:

Amgen, Merck, Servier, Pierre Fabre, Sanofi, Lilly, Onkowissen, AstraZeneca, MSD, BMS, Seagen and GSK

Dr Thomas Winder is board certified for haematology and medical oncology. Since January 2020 he has been Head of the Department for Haematology and Oncology at the University Teaching Hospital Feldkirch, Austria. In addition, since 2017 he has been President of the Swiss Tumor Molecular Institute in Zürich Switzerland. Dr Winder’s research focuses on molecular markers to individualize medical treatment of cancer patients. He achieved his expertise in internationally renowned laboratories at University of Southern California, Norris Comprehensive Cancer Center, Los Angeles and University Hospital Zürich, Switzerland. His research activity has been honoured by several national and international awards and high impact publications.

Dr Samuel J. Klempner is a GI medical oncologist with research and clinical focus on esophagogastric cancers and cancer genomics. Dr Klempner completed his residency in internal medicine at Brigham and Women’s Hospital/Harvard Medical School, followed by a combined hematology-oncology fellowship at Beth Israel Deaconess Medical Center/Harvard Medical School. While at Harvard, Dr Klempner studied the mechanisms of resistance to targeted therapies in tumor cells in the lab of Dr Lewis Cantley, PhD. Dr Klempner is board certified in medical oncology, hematology, and internal medicine. Prior to joining The Angeles Clinic and Research Institute Dr Klempner served as an Assistant Clinical Professor in the division of Hematology-Oncology at the University of California Irvine. Dr Klempner’s research interests include the intersection of genomics and immunotherapies, oncogene-driven tumors, acquired resistance, and experimental therapeutics. Dr Klempner is involved in professional societies including the American Society of Clinical Oncology (ASCO), American Association for Cancer Research (AACR), and the European Society for Medical Oncology (ESMO).

Dr Samuel J Klempner has received financial support/sponsorship for research support, consultation, or speaker fees from the following companies:

Astellas, AstraZeneca, BMS, Coherus, Daiichi-Sankyo, Eli Lilly, Merck, Novartis, Nuvalent Therapuetics and Sanofi.

Yelena Y. Janjigian MD, is Associate Professor and Chief of Gastrointestinal (GI) Oncology Service in the Department of Medicine at Memorial Sloan Kettering Cancer Center (MSK). Her research career and clinical practice are focused on improving treatment outcomes for patients with GI malignancies. She is an international expert in the management of cancers of oesophagus and stomach and lead several seminal studies that changed practice and set the standard of care for these diseases. She produced high impact publications describing the genomic basis for oesophagogastric cancer pathogenesis and secure federal grants to fund future studies. Her research is focused on developing new treatments, with a special emphasis on defining the therapeutically relevant molecular characteristics of tumors in the GI tract, with 120 peer-reviewed publications to date.

Dr Janjigian received her BS from the University of California, San Diego and her MD from the New York University School of Medicine. She did her internal medicine residency at New York School of Medicine/Bellevue Hospital and her haematology/oncology fellowship training at MSKCC. She joined the MSK faculty in 2009 as a member of the GI Oncology Service.

Dr Janjigian is an active member of American Society of Clinical Oncology (ASCO), American Association of Cancer Research (AACR) and European Society for Medical Oncology (ESMO) holding an array of leadership positions. As Chief of the GI Oncology Service, Dr Janjigian’s mission is to foster research and innovation that transform the future of GI oncology to help patients worldwide. 

Dr Yelena Janjigian has received financial support/sponsorship for research support, consultation, or speaker fees from the following companies:

Research Funding: Bayer, Bristol-Myers Squibb, Cycle for Survival, Department of Defense, Eli Lilly, Fred’s Team, Genentech/Roche, Merck, NCI, RGENIX

Advisory Boards/Consulting: Amerisource Bergen, Arcus Biosciences, AstraZeneca, Basilea Pharmaceutica, Bayer, Bristol-Myers Squibb, Daiichi-Sankyo, Eli Lilly, Geneos Therapeutics, GlaxoSmithKline, Imedex, Imugene, Lynx Health, Merck, Merck Serono, Michael J. Hennessy Associates, Paradigm Medical Communications, PeerView Institute, Pfizer, Research to Practice, RGENIX, Seagen, Silverback Therapeutics, Zymeworks Inc.

Other: RGENIX (stock options)

 

Programme summary
  • clock Duration 2 MIN
  • clock HCPs enrolled 125 HCPs
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Other episodes in this series
GI CONNECT Update from ESMO 2022

GI CONNECT Update from ESMO 2022

Episode 1: Lower GI cancer highlights

GI CONNECT Update from ESMO 2022

GI CONNECT Update from ESMO 2022

Episode 2: Upper GI cancer highlights

GI CONNECT Update from ESMO 2022

GI CONNECT Update from ESMO 2022

Episode 3: Presidential session

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