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Radiopharmaceuticals in prostate cancer – radium-223 (Episode 1 of 2)

Radiopharmaceuticals in prostate cancer – radium-223 (Episode 1 of 2)

Episode 1 focuses on radium-223 and guest speaker Dr Neal Shore joins the discussion. Episode 1 focuses on radium-223 and guest speaker Dr Neal Shore joins the discussion.

Dr. Neal D. Shore, Assoc. Prof. Tanya Dorff, Dr. Phillip Koo

Listen to the first episode - radium-223
Portrait of Neal D. Shore
Dr. Neal D. Shore

Urologist

Carolina Urologic Research Centre and GenesisCare

United States (US)

Portrait of Tanya Dorff
Assoc. Prof. Tanya Dorff

Medical Oncologist

City of Hope Comprehensive Cancer Center

United States (US)

Portrait of Phillip Koo
Dr. Phillip Koo

Nuclear Medicine Physician

Banner MD Anderson Cancer Center

United States (US)

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time Podcast | open 30 min |accreditation: EACCME

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Radiopharmaceuticals in prostate cancer - radium-223 (Episode 1 of 2)

In this GU CONNECT podcast series international experts, Assoc. Prof. Tanya Dorff and Dr. Phillip Koo, from the field of GU Oncology and Nuclear Medicine discuss the latest developments in the field of radiopharmaceuticals and their use in Prostate Cancer.  Episode 1 focuses on radium-223 and guest speaker Dr. Neal Shore joins the discussion.

In the first episode, the experts focus on the alpha emitter, radium-223 which received regulatory approval on the basis of the phase 3 ALSYMPCA trial in patients with metastatic castration-resistant prostate cancer (mCRPC) and symptomatic bone metastases. They consider mechanism of action and discuss key results from the trial and the safety profile.

The experts also review the ERA-223 and PEACE-III randomised trials which investigated the use of radium-223 in combination with next-generation androgen receptor inhibitors (ARI’s).  A number of real-world evidence studies are also reviewed as the experts consider where radium-223 fits into the overall treatment sequence for mCRPC patients. Radiation safety and general considerations for delivering therapy with radiopharmaceuticals are also discussed.

Episode two focuses on PSMA-targeted radiopharmaceuticals and how PSMA can be a therapeutic target as well as for imaging. Efficacy and safety data from the phase 2 TheraP study are discussed which investigated lutetium-PSMA versus cabazitaxel in patients with mCRPC who had progressed on docetaxel.

The experts also discuss the ongoing VISION trial and what the results may mean for clinical practice as well as other ongoing trials looking at lutetium-PSMA in combination with other prostate cancer therapies such as PARP inhibitors, immunotherapies, hormonal therapies and chemotherapy. Treatment sequencing is also considered in terms of where lutetium-PSMA fits into clinical practice for mCRPC patients and how the treatment compares to Radium-223.

Other programmes of interest

Other programmes developed by Dr. Neal D. Shore

Other programmes developed by Assoc. Prof. Tanya Dorff

Other programmes developed by Dr. Phillip Koo