You can now access the on-demand resources from a virtual Experts Knowledge Share on the evolving TROP2-directed antibody-drug conjugate (ADC) landscape in metastatic non-small cell lung cancer (NSCLC) and strategies to optimise the treatment experience.
Renowned experts Prof. Nicolas Girard (France), Dr Louise Lim (UK), Dr Jacob Sands (US), and Mrs Stephanie McDonald (US) discuss the following topics:
- The relevance of TROP2 in metastatic NSCLC
- Clinical overview of TROP2-directed ADCs in NSCLC:
- With/without actionable genomic alterations
- Optimising the treatment experience: proactive monitoring and management of adverse events
- Best practice management: panel discussion and audience questions
Watch the video replay, or navigate to the conversation highlights or accompanying slides using the tabs above.
Clinical takeaways
- TROP2-ADCs are emerging as a promising therapeutic option across multiple treatment settings in NSCLC
- Datopotamab deruxtecan has received FDA approval, while sacituzumab tirumotecan is approved in China, reflecting growing global adoption of this class
- TROP2-ADCs demonstrate generally consistent and manageable safety profiles, with commonly observed adverse events including stomatitis, nausea, fatigue, and hematologic toxicities
- These agents are associated with specific toxicities that require a multidisciplinary approach, early recognition, and timely intervention
- Proactive prophylaxis and structured toxicity management are essential to support treatment continuity and optimise patient outcomes
- Ongoing phase 3 trials will further clarify the efficacy, safety, and positioning of TROP2-ADCs within the NSCLC treatment landscape

5 MIN
May 2026
Downloadable
