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VEGFR-TKI Monotherapy in the Treatment of Unresectable or Advanced HCC (First-Line Setting)

VEGFR-TKI Monotherapy in the Treatment of Unresectable or Advanced HCC (First-Line Setting)

Prof. Josep Llovet, Prof. Stephen L. Chan

Prof. Josep Llovet and Prof. Stephen L. Chan discuss which patients can benefit, and they provide guidance on implementation of dosing strategies and patient pre-habilitation, for prediction of efficacy and toxicity.
Portrait of Josep Llovet
Prof. Josep Llovet

Hepatic Oncologist

University of Barcelona & School of Medicine at Mount Sinai

Spain

Potrait of Stephen L. Chan
Prof. Stephen L. Chan

Clinical Oncologist

The Chinese University of Hong Kong

Hong Kong

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time Podcast | open 30 min | Oct 2021

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In this podcast, Prof. Josep Llovet and Prof. Stephen L. Chan describe patients who can benefit from monotherapy, and they  share current guidance on implementation of dosing strategies for the management of toxicity in clinical practice. They discuss first line monotherapy with TKI (lenvatinib or sorafenib) for patients who are not suitable for the treatment with atezo-bev combination (around 20% of the patients), which is the current standard of care. They summarize the HCC patients who are not ideal for this I/O combination, such as HCC patients with liver transplantation, high bleeding risk, impaired liver function or severe autoimmune disease.

 

The experts discuss which patients can benefit from TKI and provide a summary of efficacy and safety data from several pivotal clinical studies (including SHARP, REFLECT, IMbrave150), as well as real-world data. Dosing strategies for VEGFR-TKIs and management of AEs are discussed, as well as guideline recommendations. Finally, the experts anticipate key developments over the next few years, focusing on the new immunotherapy combinations that could become new standard of care.

 

This HCC CONNECT podcast is also available on
Castos, Spotify, Apple Podcasts, and Google Podcasts.

HCC CONNECT is an initiative of COR2ED, supported by an Independent Educational Grant from Bayer and from Eisai Europe Limited.

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