In this conference update, Dr Samuel Klempner and Dr Lizzy Smyth share their key highlights from ASCO 2024 and provide insights into how new data from the ESOPEC, IKF-575/RENAISSANCE, and ARMANI trials could impact clinical practice.

 

ASCO 2024 selected upper GI cancer abstracts

 

  • Prospective randomised multicentre phase 3 trial comparing perioperative chemotherapy (FLOT protocol) to neoadjuvant chemoradiation (CROSS protocol) in patients with adenocarcinoma of the oesophagus (ESOPEC trial).
    Hoeppner J, et al.
    Abstract LBA1, ASCO 2024

 

  • Effect of chemotherapy/targeted therapy alone vs. chemotherapy/targeted therapy followed by radical surgical resection on survival and quality of life in patients with limited-metastatic adenocarcinoma of the stomach or oesophagogastric junction: The IKF-575/RENAISSANCE phase 3 trial.
    Al-Batran S-E, et al.
    Abstract LBA4001, ASCO 2024

 

  • Ramucirumab plus paclitaxel as switch maintenance versus continuation of oxaliplatin-based chemotherapy in patients with advanced HER2-negative gastric or gastroesophageal junction cancer: The ARMANI phase 3 trial.
    Pietrantonio F, et al.
    Abstract LBA4002, ASCO 2024

 

Dr. Klempner is an Associate Professor at Massachusetts General Hospital and Harvard Medical School and leads the gastric and oesophageal programme. His clinical and translational research is centred on cancer genomics, acquired resistance to targeted therapies and the intersection of genomics and immune mediated therapies to identify novel therapeutic approaches and biomarkers in gastroesophageal cancers. He serves on the NRG non-colorectal committee, co-chairs the NCI oesophagogastric task force, and is on the NCCN guideline committees for gastric and oesophageal cancers. His work is supported by Stand Up 2 Cancer, NCI/NIH, AACR, the Degregorio Foundation, and The Gastric Cancer Foundation and Gateway for Cancer Research. He is active in gastric and oesophageal cancer outreach and patient advocacy.

Assoc. Prof. Samuel J Klempner has received financial support/sponsorship for research support, consultation, or speaker fees from the following companies:

Astellas, AstraZeneca, BMS, Coherus, Daiichi-Sankyo, Eli Lilly, Merck, Novartis, Nuvalent Therapuetics and Sanofi.

Elizabeth (Lizzy) Smyth is a consultant in gastrointestinal oncology. Dr Smyth commenced her oncology training in Dublin, Ireland. In 2009 she was awarded a fellowship from the Irish Society of Medical Oncology to train at Memorial Sloan-Kettering Centre, New York. Following this, she worked at the Royal Marsden Hospital in London from 2011-2018. Her research focus is on clinical trials and translational research in gastroesophageal cancer, and she has worked on trial design and management of national and international trials. She is a member of the European Society for Medical Oncology GI Faculty and leads the EORTC GI Trials Group Gastric Cancer Taskforce. Dr Smyth is committed to furthering national and international collaboration in GI trials research.

Dr Elizabeth Smyth has received financial support/sponsorship for research support, consultation, or speaker fees from the following companies:

Grants from Bristol-Myers Squibb and Astra Zeneca, personal fees from Amgen, Astellas, Astra Zeneca, Beigene, Bristol-Myers Squibb, Daiichi Sankyo, Merck, Mirati, Novartis, Pfizer, Viracta, and Zymeworks. Chair of the European Organisation for Research and Treatment of Cancer Gastrointestinal Group (2024–26), and has been trustee of the UK & Ireland Oesophagogastric Cancer Group since 2022; and is supported by the National Institute for Health Research (NIHR) Biomedical Research Centre

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