Actionable fusions in solid tumours

Refresh your knowledge with this precision oncology clinical topic update from pathologist Prof. Fernando López-Ríos.

Prof. López-Ríos gives an overview of gene fusions in solid tumours, methods for identification and the different tumour types harbouring gene fusions. He highlights the need to search for actionable fusions and the implications for treatment.

Clinical takeaways

• Several fusions are now actionable in solid tumours
• Most of them were initially studied in NSCLC (ALK, ROS1 and RET), but many are now being developed in a tumour-agnostic manner (NTRK, RET, FGFR)
• The gold standard for detecting fusions is RNA-based NGS, but IHC, FISH and real-time PCR can also be used