You can now access the on-demand resources from a virtual Experts Knowledge Share on the evolving TROP2-directed antibody-drug conjugate (ADC) landscape in metastatic non-small cell lung cancer (NSCLC) and strategies to optimise the treatment experience.

 

Renowned experts Prof. Nicolas Girard (France), Dr Louise Lim (UK), Dr Jacob Sands (US), and Mrs Stephanie McDonald (US) discuss the following topics:

 

  • The relevance of TROP2 in metastatic NSCLC
  • Clinical overview of TROP2-directed ADCs in NSCLC:
    • With/without actionable genomic alterations
  • Optimising the treatment experience: proactive monitoring and management  of adverse events
  • Best practice management: panel discussion and audience questions 

 

Watch the video replay, or navigate to the conversation highlights or accompanying slides using the tabs above.

 

Clinical takeaways

  • TROP2-ADCs are emerging as a promising therapeutic option across multiple treatment settings in NSCLC
  • Datopotamab deruxtecan has received FDA approval, while sacituzumab tirumotecan is approved in China, reflecting growing global adoption of this class
  • TROP2-ADCs demonstrate generally consistent and manageable safety profiles, with commonly observed adverse events including stomatitis, nausea, fatigue, and hematologic toxicities
  • These agents are associated with specific toxicities that require a multidisciplinary approach, early recognition, and timely intervention
  • Proactive prophylaxis and structured toxicity management are essential to support treatment continuity and optimise patient outcomes
  • Ongoing phase 3 trials will further clarify the efficacy, safety, and positioning of TROP2-ADCs within the NSCLC treatment landscape
  • Assess the clinical relevance of TROP2-targeted antibody–drug conjugates (ADCs) in NSCLC and their role in evolving treatment strategies
  • Recognise the potential adverse events associated with TROP2-directed ADCs in metastatic NSCLC, including Dato-DXd
  • Be able to implement strategies to prevent, minimise and manage adverse events associated with TROP2-directed ADCs to achieve optimal outcomes for NSCLC patients

Nicolas Girard is a pneumologist specialising in thoracic oncology, for the treatment of patients with lung cancer or rare thoracic cancers. His expertise ranges from the development of perioperative strategies in resectable tumors, to the management of locally-advanced disease and oncogene-addicted tumors, especially EGFR-mutant NSCLC. 

Nicolas Girard is involved in several clinical and translational research projects aiming at improving the treatment of these cancers. 

He is Professor of Respiratory Medicine at Versailles Saint Quentin University, Paris Saclay Campus. He is the Head of the Curie-Montsouris Thorax Institute, and Chair of Medical Oncology Departement at Institut Curie in Paris.

Nicolas Girard co-authored more than 300 articles in peer-reviewed journals.

Prof. Nicolas Girard has received financial support/sponsorship for research support, consultation, or speaker fees from the following companies:

Research grants/support from Abbvie, Amgen, AstraZeneca, Beigene, Boehringer  Ingelheim, Bristol Myers Squibb, Daiichi-Sankyo, Gilead, Hoffmann-La Roche, Janssen,  Leo Pharma, Lilly, Merk Serono, Merck Sharp & Dohme, Novartis, Sanofi and Sivan.

Consultative services for Abbvie,  Amgen, AstraZeneca, Beigene, Bristol Myers Squibb, Daiichi-Sankyo, Gilead, Ipsen  Hoffmann-La Roche, Janssen, Leo Pharma, Lilly, Merck Sharp & Dohme, Mirati, Novartis, Pfizer,  Pierre Fabre, Sanofi and Takeda.

Participation on a data safety monitoring board for Hoffmann-La Roche.

Employment of a family member with AstraZeneca.

Dr. Farah Louise Lim is a Medical Oncologist at St Bartholomew’s Cancer centre, London, where she leads the lung cancer clinical trials unit.

 

Her research focuses on novel therapies for early- and late-stage lung cancer, particularly antibody–drug conjugates (ADCs) and bispecific antibodies, alongside the development of biomarkers to guide therapy selection and improve patient outcomes.

Dr Louise Lim has received financial support/sponsorship for research support, consultation, or speaker fees from the following companies:

AstraZeneca, Astellas, BMS, Gilead, MSD, Merck-Serono, Pfizer & Roche. 

Associate Chief of the Lowe Center for Thoracic Oncology at Dana-Farber Cancer Institute and Assistant Professor of Medicine at Harvard Medical School.

 

Dr Sands received his MD from the University of Cincinnati in 2005.

He completed his residency in internal medicine at the University of California, Davis and fellowship training in hematology/oncology also at the University of California, Davis.

He joined the faculty in the Lowe Center for Thoracic Oncology at Dana-Farber in 2017 and is the Associate Chief.

His research focuses on improved diagnostics and treatments for lung cancer and is a co-founder and President of the Rescue Lung Society, a non-profit medical society focused on advancing lung screening.

Dr Jacob Sands has received financial support/sponsorship for research support, consultation, or speaker fees from the following companies:

Consulting: Abbvie, Amgen, AstraZeneca, Boehringer Ingleheim, Catalyst, Daiichi Sankyo, Fosun, Genetech, Gilead, Jazz Pharmaceuticals, Lilly, Merck, Novartis, Pfizer, Pharma Mar, Sanofi 

 

Research to institution: Amgen, Novartis

Stephanie McDonald is a Nurse Practitioner in the Thoracic Oncology Program at Dana-Farber Cancer Institute, where she specialises in providing advanced care for patients with non-small cell lung cancer (NSCLC), small cell lung cancer (SCLC) and other thoracic malignancies. Stephanie works closely with multidisciplinary teams to develop personalised treatment plans, manage side effects, and support patients and their families throughout their cancer journey.

 

Stephanie is actively involved in research and education, contributing to the evolving landscape of NSCLC and SCLC care. She has presented at national and international conferences, sharing insights on innovative therapies and best practices in thoracic oncology nursing. Her work has been published in esteemed journals such as the Journal of Cancer Research, The Journal of Clinical Oncology, The Oncologist, and Journal of The Advanced Practitioner in Oncology. Most recently, she co-authored a nurse resource guide on Bispecific T Cell Engagers in solid tumors, further highlighting her commitment to advancing oncology nursing knowledge and improving patient outcomes.

 

Driven by a passion for empowering both her patients and fellow healthcare providers, Stephanie remains at the forefront of NSCLC and SCLC care, blending compassionate nursing practice with evidence-based research and education.

Mrs Stephanie McDonald has received financial support/sponsorship for research support, consultation, or speaker fees from the following companies:

No financial disclosures

You can now access the on-demand resources from a virtual Experts Knowledge Share on the evolving TROP2-directed antibody-drug conjugate (ADC) landscape in metastatic non-small cell lung cancer (NSCLC) and strategies to optimise the treatment experience.

 

Renowned experts Prof. Nicolas Girard (France), Dr Louise Lim (UK), Dr Jacob Sands (US), and Mrs Stephanie McDonald (US) discuss the following topics:

 

  • The relevance of TROP2 in metastatic NSCLC
  • Clinical overview of TROP2-directed ADCs in NSCLC:
    • With/without actionable genomic alterations
  • Optimising the treatment experience: proactive monitoring and management  of adverse events
  • Best practice management: panel discussion and audience questions 

 

This short video shows the conversation highlights; watch the full video and view or download the slides from the tabs above.

 

Clinical takeaways

  • TROP2-ADCs are emerging as a promising therapeutic option across multiple treatment settings in NSCLC
  • Datopotamab deruxtecan has received FDA approval, while sacituzumab tirumotecan is approved in China, reflecting growing global adoption of this class
  • TROP2-ADCs demonstrate generally consistent and manageable safety profiles, with commonly observed adverse events including stomatitis, nausea, fatigue, and hematologic toxicities
  • These agents are associated with specific toxicities that require a multidisciplinary approach, early recognition, and timely intervention
  • Proactive prophylaxis and structured toxicity management are essential to support treatment continuity and optimise patient outcomes
  • Ongoing phase 3 trials will further clarify the efficacy, safety, and positioning of TROP2-ADCs within the NSCLC treatment landscape
  • Assess the clinical relevance of TROP2-targeted antibody–drug conjugates (ADCs) in NSCLC and their role in evolving treatment strategies
  • Recognise the potential adverse events associated with TROP2-directed ADCs in metastatic NSCLC, including Dato-DXd
  • Be able to implement strategies to prevent, minimise and manage adverse events associated with TROP2-directed ADCs to achieve optimal outcomes for NSCLC patients

Nicolas Girard is a pneumologist specialising in thoracic oncology, for the treatment of patients with lung cancer or rare thoracic cancers. His expertise ranges from the development of perioperative strategies in resectable tumors, to the management of locally-advanced disease and oncogene-addicted tumors, especially EGFR-mutant NSCLC. 

Nicolas Girard is involved in several clinical and translational research projects aiming at improving the treatment of these cancers. 

He is Professor of Respiratory Medicine at Versailles Saint Quentin University, Paris Saclay Campus. He is the Head of the Curie-Montsouris Thorax Institute, and Chair of Medical Oncology Departement at Institut Curie in Paris.

Nicolas Girard co-authored more than 300 articles in peer-reviewed journals.

Prof. Nicolas Girard has received financial support/sponsorship for research support, consultation, or speaker fees from the following companies:

Research grants/support from Abbvie, Amgen, AstraZeneca, Beigene, Boehringer  Ingelheim, Bristol Myers Squibb, Daiichi-Sankyo, Gilead, Hoffmann-La Roche, Janssen,  Leo Pharma, Lilly, Merk Serono, Merck Sharp & Dohme, Novartis, Sanofi and Sivan.

Consultative services for Abbvie,  Amgen, AstraZeneca, Beigene, Bristol Myers Squibb, Daiichi-Sankyo, Gilead, Ipsen  Hoffmann-La Roche, Janssen, Leo Pharma, Lilly, Merck Sharp & Dohme, Mirati, Novartis, Pfizer,  Pierre Fabre, Sanofi and Takeda.

Participation on a data safety monitoring board for Hoffmann-La Roche.

Employment of a family member with AstraZeneca.

Dr. Farah Louise Lim is a Medical Oncologist at St Bartholomew’s Cancer centre, London, where she leads the lung cancer clinical trials unit.

 

Her research focuses on novel therapies for early- and late-stage lung cancer, particularly antibody–drug conjugates (ADCs) and bispecific antibodies, alongside the development of biomarkers to guide therapy selection and improve patient outcomes.

Dr Louise Lim has received financial support/sponsorship for research support, consultation, or speaker fees from the following companies:

AstraZeneca, Astellas, BMS, Gilead, MSD, Merck-Serono, Pfizer & Roche. 

Associate Chief of the Lowe Center for Thoracic Oncology at Dana-Farber Cancer Institute and Assistant Professor of Medicine at Harvard Medical School.

 

Dr Sands received his MD from the University of Cincinnati in 2005.

He completed his residency in internal medicine at the University of California, Davis and fellowship training in hematology/oncology also at the University of California, Davis.

He joined the faculty in the Lowe Center for Thoracic Oncology at Dana-Farber in 2017 and is the Associate Chief.

His research focuses on improved diagnostics and treatments for lung cancer and is a co-founder and President of the Rescue Lung Society, a non-profit medical society focused on advancing lung screening.

Dr Jacob Sands has received financial support/sponsorship for research support, consultation, or speaker fees from the following companies:

Consulting: Abbvie, Amgen, AstraZeneca, Boehringer Ingleheim, Catalyst, Daiichi Sankyo, Fosun, Genetech, Gilead, Jazz Pharmaceuticals, Lilly, Merck, Novartis, Pfizer, Pharma Mar, Sanofi 

 

Research to institution: Amgen, Novartis

Stephanie McDonald is a Nurse Practitioner in the Thoracic Oncology Program at Dana-Farber Cancer Institute, where she specialises in providing advanced care for patients with non-small cell lung cancer (NSCLC), small cell lung cancer (SCLC) and other thoracic malignancies. Stephanie works closely with multidisciplinary teams to develop personalised treatment plans, manage side effects, and support patients and their families throughout their cancer journey.

 

Stephanie is actively involved in research and education, contributing to the evolving landscape of NSCLC and SCLC care. She has presented at national and international conferences, sharing insights on innovative therapies and best practices in thoracic oncology nursing. Her work has been published in esteemed journals such as the Journal of Cancer Research, The Journal of Clinical Oncology, The Oncologist, and Journal of The Advanced Practitioner in Oncology. Most recently, she co-authored a nurse resource guide on Bispecific T Cell Engagers in solid tumors, further highlighting her commitment to advancing oncology nursing knowledge and improving patient outcomes.

 

Driven by a passion for empowering both her patients and fellow healthcare providers, Stephanie remains at the forefront of NSCLC and SCLC care, blending compassionate nursing practice with evidence-based research and education.

Mrs Stephanie McDonald has received financial support/sponsorship for research support, consultation, or speaker fees from the following companies:

No financial disclosures

You can now access the on-demand resources from a virtual Experts Knowledge Share on the evolving TROP2-directed antibody-drug conjugate (ADC) landscape in metastatic non-small cell lung cancer (NSCLC) and strategies to optimise the treatment experience.

 

Renowned experts Prof. Nicolas Girard (France), Dr Louise Lim (UK), Dr Jacob Sands (US), and Mrs Stephanie McDonald (US) discuss the following topics:

 

  • The relevance of TROP2 in metastatic NSCLC
  • Clinical overview of TROP2-directed ADCs in NSCLC:
    • With/without actionable genomic alterations
  • Optimising the treatment experience: proactive monitoring and management  of adverse events
  • Best practice management: panel discussion and audience questions 

 

View or download the slides for your reference, or navigate to the full video or conversation highlights using the tabs above.

 

Clinical takeaways

  • TROP2-ADCs are emerging as a promising therapeutic option across multiple treatment settings in NSCLC
  • Datopotamab deruxtecan has received FDA approval, while sacituzumab tirumotecan is approved in China, reflecting growing global adoption of this class
  • TROP2-ADCs demonstrate generally consistent and manageable safety profiles, with commonly observed adverse events including stomatitis, nausea, fatigue, and hematologic toxicities
  • These agents are associated with specific toxicities that require a multidisciplinary approach, early recognition, and timely intervention
  • Proactive prophylaxis and structured toxicity management are essential to support treatment continuity and optimise patient outcomes
  • Ongoing phase 3 trials will further clarify the efficacy, safety, and positioning of TROP2-ADCs within the NSCLC treatment landscape
  • Assess the clinical relevance of TROP2-targeted antibody–drug conjugates (ADCs) in NSCLC and their role in evolving treatment strategies
  • Recognise the potential adverse events associated with TROP2-directed ADCs in metastatic NSCLC, including Dato-DXd
  • Be able to implement strategies to prevent, minimise and manage adverse events associated with TROP2-directed ADCs to achieve optimal outcomes for NSCLC patients

Nicolas Girard is a pneumologist specialising in thoracic oncology, for the treatment of patients with lung cancer or rare thoracic cancers. His expertise ranges from the development of perioperative strategies in resectable tumors, to the management of locally-advanced disease and oncogene-addicted tumors, especially EGFR-mutant NSCLC. 

Nicolas Girard is involved in several clinical and translational research projects aiming at improving the treatment of these cancers. 

He is Professor of Respiratory Medicine at Versailles Saint Quentin University, Paris Saclay Campus. He is the Head of the Curie-Montsouris Thorax Institute, and Chair of Medical Oncology Departement at Institut Curie in Paris.

Nicolas Girard co-authored more than 300 articles in peer-reviewed journals.

Prof. Nicolas Girard has received financial support/sponsorship for research support, consultation, or speaker fees from the following companies:

Research grants/support from Abbvie, Amgen, AstraZeneca, Beigene, Boehringer  Ingelheim, Bristol Myers Squibb, Daiichi-Sankyo, Gilead, Hoffmann-La Roche, Janssen,  Leo Pharma, Lilly, Merk Serono, Merck Sharp & Dohme, Novartis, Sanofi and Sivan.

Consultative services for Abbvie,  Amgen, AstraZeneca, Beigene, Bristol Myers Squibb, Daiichi-Sankyo, Gilead, Ipsen  Hoffmann-La Roche, Janssen, Leo Pharma, Lilly, Merck Sharp & Dohme, Mirati, Novartis, Pfizer,  Pierre Fabre, Sanofi and Takeda.

Participation on a data safety monitoring board for Hoffmann-La Roche.

Employment of a family member with AstraZeneca.

Dr. Farah Louise Lim is a Medical Oncologist at St Bartholomew’s Cancer centre, London, where she leads the lung cancer clinical trials unit.

 

Her research focuses on novel therapies for early- and late-stage lung cancer, particularly antibody–drug conjugates (ADCs) and bispecific antibodies, alongside the development of biomarkers to guide therapy selection and improve patient outcomes.

Dr Louise Lim has received financial support/sponsorship for research support, consultation, or speaker fees from the following companies:

AstraZeneca, Astellas, BMS, Gilead, MSD, Merck-Serono, Pfizer & Roche. 

Associate Chief of the Lowe Center for Thoracic Oncology at Dana-Farber Cancer Institute and Assistant Professor of Medicine at Harvard Medical School.

 

Dr Sands received his MD from the University of Cincinnati in 2005.

He completed his residency in internal medicine at the University of California, Davis and fellowship training in hematology/oncology also at the University of California, Davis.

He joined the faculty in the Lowe Center for Thoracic Oncology at Dana-Farber in 2017 and is the Associate Chief.

His research focuses on improved diagnostics and treatments for lung cancer and is a co-founder and President of the Rescue Lung Society, a non-profit medical society focused on advancing lung screening.

Dr Jacob Sands has received financial support/sponsorship for research support, consultation, or speaker fees from the following companies:

Consulting: Abbvie, Amgen, AstraZeneca, Boehringer Ingleheim, Catalyst, Daiichi Sankyo, Fosun, Genetech, Gilead, Jazz Pharmaceuticals, Lilly, Merck, Novartis, Pfizer, Pharma Mar, Sanofi 

 

Research to institution: Amgen, Novartis

Stephanie McDonald is a Nurse Practitioner in the Thoracic Oncology Program at Dana-Farber Cancer Institute, where she specialises in providing advanced care for patients with non-small cell lung cancer (NSCLC), small cell lung cancer (SCLC) and other thoracic malignancies. Stephanie works closely with multidisciplinary teams to develop personalised treatment plans, manage side effects, and support patients and their families throughout their cancer journey.

 

Stephanie is actively involved in research and education, contributing to the evolving landscape of NSCLC and SCLC care. She has presented at national and international conferences, sharing insights on innovative therapies and best practices in thoracic oncology nursing. Her work has been published in esteemed journals such as the Journal of Cancer Research, The Journal of Clinical Oncology, The Oncologist, and Journal of The Advanced Practitioner in Oncology. Most recently, she co-authored a nurse resource guide on Bispecific T Cell Engagers in solid tumors, further highlighting her commitment to advancing oncology nursing knowledge and improving patient outcomes.

 

Driven by a passion for empowering both her patients and fellow healthcare providers, Stephanie remains at the forefront of NSCLC and SCLC care, blending compassionate nursing practice with evidence-based research and education.

Mrs Stephanie McDonald has received financial support/sponsorship for research support, consultation, or speaker fees from the following companies:

No financial disclosures

Programme summary
Watch the video now
Share this programme
This educational programme is supported by an Independent Educational Grant from AstraZeneca
Supporter Acknowledgement
This educational programme is supported by an Independent Educational Grant from AstraZeneca
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Was valuable to me

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Brought to you by
LUNG CONNECT

LUNG CONNECT is an initiative of COR2ED, supported by Independent Educational Grants from Bayer, Pierre Fabre Laboratories, Boehringer Ingelheim and AstraZeneca.

Meet the experts
Brought to you by
PRECISION ONCOLOGY CONNECT

PRECISION ONCOLOGY CONNECT is an initiative of COR2ED, supported by Independent Educational Grants from AstraZeneca, Amoy Diagnostics, Bayer, Pierre Fabre Laboratories, Thermo Fisher Scientific and Daiichi Sankyo.

Meet the experts Independent IME approved
Programme summary
Watch the video now
Share this programme
This educational programme is supported by an Independent Educational Grant from AstraZeneca
Supporter Acknowledgement
This educational programme is supported by an Independent Educational Grant from AstraZeneca
Endorsement
I agree that this educational programme:

Was valuable to me

1/4
Brought to you by
LUNG CONNECT

LUNG CONNECT is an initiative of COR2ED, supported by Independent Educational Grants from Bayer, Pierre Fabre Laboratories, Boehringer Ingelheim and AstraZeneca.

Meet the experts
Brought to you by
PRECISION ONCOLOGY CONNECT

PRECISION ONCOLOGY CONNECT is an initiative of COR2ED, supported by Independent Educational Grants from AstraZeneca, Amoy Diagnostics, Bayer, Pierre Fabre Laboratories, Thermo Fisher Scientific and Daiichi Sankyo.

Meet the experts Independent IME approved
Programme summary
Share this programme
This educational programme is supported by an Independent Educational Grant from AstraZeneca
Supporter Acknowledgement
This educational programme is supported by an Independent Educational Grant from AstraZeneca
I agree that this educational programme:

Was valuable to me

1/4
Brought to you by
LUNG CONNECT

LUNG CONNECT is an initiative of COR2ED, supported by Independent Educational Grants from Bayer, Pierre Fabre Laboratories, Boehringer Ingelheim and AstraZeneca.

Meet the experts
Brought to you by
PRECISION ONCOLOGY CONNECT

PRECISION ONCOLOGY CONNECT is an initiative of COR2ED, supported by Independent Educational Grants from AstraZeneca, Amoy Diagnostics, Bayer, Pierre Fabre Laboratories, Thermo Fisher Scientific and Daiichi Sankyo.

Meet the experts Independent IME approved

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